Senior Director, Discovery Strategy & Transformation
Gaithersburg, MD - USA
Job Summary
Job Title: Senior Director Discovery Strategy & Transformation Location:Gaithersburg MD or Boston MA
Hybrid Role: In the office minimum 3 days/week
AstraZenecas Oncology ambition is toeliminatecancer as a cause of death. Underpinning that ambition is a growing pipeline across small molecules antibody-drug conjugates (ADCs) and radio-conjugates and the relentless drive to discover and advance new medicines faster than ever before.
This role sits at the center of that effort. You will shape how AstraZenecas Oncology Discovery organization thinks about its future what to pursue how to prioritize and how to move faster working alongside discovery scientists platform leads and senior leadership to translate bold ambitions into concrete strategy and measurable change.
The Senior Director Discovery Strategy &Transformationowns two interconnected mandates: defining where Oncology Discovery isgoing andaccelerating how it gets there.
On strategy you will develop and steward the 5- and 10-year Oncology Discovery portfolio strategy integrating scientific clinical and commercial perspectives across small molecules ADCs and radio-conjugates to set clear priorities for the senior leadership team.
On transformation you will drive meaningful cycle time acceleration across the discovery engine deploying AI and automation redesigning processes and building the cultural shifts needed to move faster from target to candidate.
You bring the structured strategicthinkingandthe scientificdepth to earn credibility with world-class researchers. You are comfortable operating with ambiguity influencing without authority and translating complexity into clarity for executive audiences.
Key Accountabilities
Discovery Portfolio Strategy
Develop and own the 5- and 10-year Oncology Discovery portfolio strategy across small molecules ADCs and radio-conjugates integrating scientific&clinical insights to shape investment priorities
Partner with discovery scientists platform leads BD and global strategy teams to build cohesive long-term strategies that reflect the latest science and competitive landscape
Translate portfolio strategy into clear recommendations for senior leadership: options tradeoffs and priorities grounded in rigorous analysis
Supportinternal & external innovationdecisions across modalities and platforms bringing analytical structure to high-stakes choices
Discovery Transformation
Lead the design and execution of initiatives to accelerate discovery cycle times spanning AI and automation adoption process redesign and organizational change
Identifyand prioritize the highest-leverage transformation opportunities across the discovery pipeline from target identification through candidate nomination
Work with AI data and platform teams to define where technology can meaningfully compress timelines and drive adoption of new capabilities with discovery teams
Build the case for change with scientific and leadership stakeholders; sustain momentum through cultural shifts and performance tracking
Stakeholder Alignment & Communication
Synthesize strategy and transformation progress into leadership-ready materials for senior executive and global R&D audiences
Build credibility and influence with senior scientists and cross-functional leaders through rigorous analysis clear communication and follow-through
Ensure strategic priorities are clearly understood and consistently reflected across discovery functions and partner teams
EssentialRequirements
M.D.and/orPh.D.in a life science discipline (oncology cancer biology chemistry biochemistry or relatedfield) scientific credibility with discovery researchers is essential
4 years of strategy consulting experience at McKinsey BCG Bain or equivalent top-tier firm
Demonstratedtrack recordof structuring complex problemsand delivering clear evidence-based recommendations to senior stakeholders
Experience working across cross-functional teamsin biopharma biotech or adjacent life science environments preferred
Oncology domainexpertise:familiarity with small molecule drug discovery ADC biology or radio-conjugate platforms
Experience with AI/ML applicationsin drug discovery or scientific R&D settings
Prior exposure to portfolio management clinical development strategy or business development in biopharma
Experience supporting or presentingto C-suite or senior R&D leadership
Skills& Competencies
Deep scientific fluency:able to engage substantively with discovery scientists on target biology modalityselection and portfolio tradeoffs
Exceptional structured thinking:hypothesis-driven analysis issue trees and synthesis of complex information into executive-ready narratives
Strategic judgment:comfortable translating ambiguous scientific and commercial inputs into clear priorities and investment recommendations
Transformation mindset:experience driving organizational or process change with an understanding of how AI and automation can accelerate scientific workflows
Stakeholder management:able to influence and align experienced scientists and senior leaders without formal authority
Energized by the mission:genuine commitment to accelerating cancer drug discovery and belief that strategy and transformation can make a measurable difference
Comfortable at the interface of science and strategy as credible in a whiteboard session with discovery scientists as in an executive review
Low egohigh standards:willing to do the analytical work and build the coalitions needed to move things forward
Comfortable with ambiguity:the strategy will evolve and priorities will shift as science and the competitive environmentdevelop
The annual base pay ranges from 231988.80 - 347983.20 Hourly and salaried non-exempt employees will also be paid overtime pay when workingqualifying overtime pay offered may vary depending on multiple individualized factors including marketlocation job-related knowledge skills and addition our positions offer a short-term incentive bonusopportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles)to receive aretirement contribution (hourly roles) and commission payment eligibility (sales roles). Benefits offered included aqualified retirement program 401(k) plan; paid vacation and holidays; paid leaves; and health benefits includingmedical prescription drug dental and vision coverage in accordance with the terms and conditions of the applicableplans. Additional details of participation in these benefit plans will be provided if an employee receives an offer ofemployment. If hired employee will be in an at-will position and the Company reserves the right to modify basepay(as well as any other discretionary payment or compensation program) at any time including for reasons related toindividual performance Company or individual department/team performance and market factors.
Date Posted
15-May-2026Closing Date
28-May-2026Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and furtherance of that mission we welcome and consider applications from all qualified candidates regardless of their protected characteristics. If you have a disability or special need that requires accommodation please complete the corresponding section in the application form.
Required Experience:
Exec
About Company
AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, ... View more