Director, Biologics

Embedded within the Broad Institute of Harvard and MIT the Center for the Development of Therapeutics (CDoT) is a highly collaborative organization of professional drug discovery scientists. Our mission is to translate the deep biological insights emerging from the Broad community into new therapeutics. To accomplish this mission we partner with faculty from MIT Harvard and the Harvard teaching hospitals together with industry professionals in pharmaceutical biotechnology and venture capital firms and advance cutting-edge drug discovery projects. We also create new technologies and work to combine the unique capabilities of the Broad Institute to enable new therapeutic approaches that will broadly benefit the scientific community.

We are seeking an experienced and creative Director of Biologics to serve as the strategic head of biologics research at the Broad Institutes Center for the Development of Therapeutics. This new leader will set the long-term vision for how biologics integrate into the Broads mission of translating biological insights into life-changing therapeutics. This role will be responsible for building a team that will guide the discovery optimization and preclinical development of novel protein- and antibody-based therapeutics. The successful candidate will be a recognized leader in the field and have deep expertise in biologics R&D a proven track record in therapeutic protein engineering and experience leading cross-functional teams to advance molecules toward clinical development. This is a unique opportunity for an experienced and creative leader to work at the interface of industry and academia to advance projects from concept to clinic.

Responsibilities

• Develop and lead the Broads therapeutic approach to biologics working closely with Broad faculty and CDoT leadership.
• Build and manage CDoTs portfolio of biologic discovery projects
• Mentor scientists and project leaders to build a world class biologics therapeutics research team within the Broad
• Create strategies and lead efforts to fund early discovery projects leveraging Broads industry philanthropic and government relationships.
• Lead alliance and partnership discussions with VC biotech pharma companies for therapeutic assets developed by the Broad and identify new opportunities and partners.
• Mentor and manage scientists in the design engineering and optimization of novel biologics including monoclonal antibodies multi-specifics fusion proteins and other protein-based therapeutics.
• Direct preclinical development including in vitro and in vivo characterization pharmacokinetics pharmacodynamics and toxicology studies by establishing partnerships with external CROs and technology providers that accelerate programs.
• Work across Broad Platforms to identify new opportunities in technology development that will accelerate drug discovery projects and advance the mission of the Institute.
• Stay abreast of emerging biologics technologies novel therapeutic modalities and industry trends to guide strategic decision-making. Speak and present at conferences to ensure the Broad is recognized as a creative leader in novel biologics discovery.

Qualifications

• PhD in Molecular Biology Biochemistry Immunology Protein Engineering or related field. The ideal candidate will have a significant publication record demonstrating deep expertise in protein engineering antibody discovery and development or biochemistry and biophysics.
• 15 years of industry experience in biologics discovery is essential.
• Demonstrated success leading projects from target ID to clinical development.
• Experience leading cross-functional teams motivating and leading scientifically diverse teams; experience and comfort when leading without authority.