Vice President, Biology and Translational Science

Company Summary:

Prologue Medicines uses advances in structural predictions and large language models to functionally annotate the entire viral proteome toleveragemillennia of viral evolution for the development of transformative medicines. Prologue has nominated two development candidatesand is building a broad pipeline of therapeutics across several therapeutic ofPrologue Medicinesfounding principles is to build an inclusive and exciting working environment that fosters personal and professional growth by ensuring that all team members contribute to and feel ownership of our scientific vision.

Flagship Pioneering is a biotechnology company that invents and builds platform companies each with the potential for multiple products that transform human health or sustainability. Since its launch in 2000 Flagship has originated and fostered more than 100 scientific ventures resulting in more than$90 billionin aggregate value. Many of thecompaniesFlagship has founded have addressed humanitys most urgent challenges: vaccinating billions of people against COVID-19 curing intractable diseases improving human health preempting illness and feeding the world by improving the resiliency and sustainability of agriculture.

Flagship has been recognized twice on FORTUNEs Change the World list an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Companys annual list of the Worlds Most Innovative Companies. Learn more about Flagship at.

Position Summary:

We are seeking an exceptional scientific leader to serve asVP/SVP Biology & Translational Science responsible for driving our discovery and early development strategy from target identification through INDand continue to support the program as needed through clinical development. This individual will integrate deepexpertisein immunologytranslationalscienceand/or protein biologicsto build a high-impact pipeline and ensure successful progression of programs into the ideal candidate will have a proven ability to develop effectivestrategiesand execution plans to advance early molecules through preclinical development to ensure emerging assetsexhibitstrong differentiation and possibility of success. They should have an excellent understanding of the landscape of immune-mediated diseases to help build a successful candidate will be an enthusiastic goal-driven individual whoparticipatesas a strategic leader while fostering a culture of executional excellence.

Key Responsibilities:

Translational Science & Clinical Readiness

• Define translational strategies to bridge preclinical findings to human studies
• Lead identification and implementation of biomarkers (PD predictive and safety)
• Ensure programs are designed with clinical endpoints and patient stratification in mind
• Increase probability of clinical success through mechanism-based approaches.
• In collaboration with PKPD/ QSP modeling team develop translational frameworks for AI enabled derisking of drug development path

Biologics Development (Hit IDtoIND)

• Lead progression of protein biologics programs from hit identification through lead optimization and IND-enabling studies
• Partner cross-functionally with discovery and development teams to build out and drive comprehensive IND strategy including pharmacology safety and translational packages
• Ensure clear go/no-go decision frameworks across discovery and preclinical stages
• Proactively recognize and develop creative solutions for emerging technical and scientific issues

Discovery Biology & Target Strategy

• Lead target identification evaluation and nomination grounded in human biology and disease relevance
• Define and drive biological hypotheses aligned with company strategy with a focus on immunology
• Oversee development of robust in vitroandin vivomodels tovalidatetargets and mechanisms
• Build and prioritize a portfolio strategy for multiple differentiated biologics programs

Leadership & Cross-Functional Integration

• Buildmentorandlead high-performing teamsdeliveringacross biology pharmacology and translational and manage productive collaborations withCROs partners andacademic labs asappropriate todriving projects forward andcollaborate closely with clinical development regulatory and executive leadership
• Develop motivate and inspire a high-performing Biology and Translational Science organization
• Serve as an enterprise leader driving cross-functional alignment clear decision-making and a culture of accountability innovation and executional excellence.
• Serve as a key scientific voice with board members investors and external partners
• Foster a culture of rigor innovation collaborative and decisive execution

Qualifications:

• PhDor MD/PhDin pharmacology or biological disciplines such as immunology cellular biology oncology or biochemistry with 10 years direct pharmaceutical experience beyond postdoctoral work
• Deep expertise in immunology with a strong understanding of disease biology
• Proven track record advancing protein biologics from hit identification to IND
• Significant experience in target selection and nomination
• Demonstrated ability to lead cross-functional teams to drive go/no go decisions
• Excellent project management skills and the ability to effectively manage CROs and to facilitate interactions with academic labs and companies to ensure project progression.
• Demonstrated success in translational science including biomarker strategy and IND-enabling work and direct experience in supporting IND strategy and documentation including writing relevant pharmacology sections of INDs.
• Flexibility to dynamical adapt workplans and lead teams through changing priorities and deadlines.
• A pioneering mindset to grow a startup venture
• Prior experience working in smaller companies is highly preferred

Leadership Profile

• Strategic thinker with strong scientific judgment
• Ability to make high-quality decisions under uncertainty
• Skilled at balancing innovation with execution discipline
• Effective communicator with strong external presence
• Passion for building teams and developing talent

Impact

This role will shape the companys scientific direction and pipeline directly influencing the success of programs entering the clinic andultimately improvingpatient outcomes.

Flagship Pioneering and our ecosystem companies arecommitted to equal employment opportunityregardless of race color ancestry religion sex national origin sexual orientation age citizenship marital status disability genderidentityor Veteran status.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively FSP) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees isstrictly prohibitedunless contacted directly by Flagship Pioneerings internal Talent Acquisition team. Any resumesubmittedby an agency in the absence of a signed agreement will automatically become the property of FSP and FSP will not owe any referral or other fees with respect thereto.

The salary range for this role is $275000 - $340000. Compensation for the role will depend on a number of factors including a candidates qualifications skills competencies and experience. Prologue Medicines Inc. currently offers healthcare coverage annual incentive program retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Prologue Medicines Inc.s good faith estimate as of the date of publication and may be modified in the future.

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