Senior Scientist, In Vitro Cardiovascular Biology

Do you have expertise within in vitro cardiovascular biology and enjoy working in the lab Would you like to apply your expertise in a global company that is accelerating innovative science and turning ideas into life-changing medicines Join us to discover future treatments for Cardiovascular Renal and Metabolic (CVRM) diseases!

We are recruiting a Senior Scientist with expertise in in vitro cardiovascular biology to Early CVRM one of AstraZenecas three main therapeutic the Bioscience department we focus on identifying and validating new drug targets and delivering preclinical data to projects across all phases of drug discovery and development.

The role is based at AstraZenecas dynamic R&D site in Gothenburg Sweden where you will join an international collaborative and innovative environment focused on scientific excellence and patient impact.

Accountability

As a Senior Scientist you will be a key laboratory-based contributor to AstraZenecas Cardiovascular Bioscience portfolio. This is an in vitrofocused role where you will play a critical role in building mechanistic understanding of drug targets by generating highquality experimental data to support target discovery target validation and drug discovery projects within cardiovascular disease.

Responsibilities include:

• Independently design develop and execute in vitro experiments and assays.

• Generate highquality mechanistic data including mechanismofaction and proofofconcept evidence for drug candidates.

• Work extensively with human pluripotent stem cellderived cardiomyocytes and other relevant cell types in both healthy and diseaserelevant settings.

• Apply molecular biology imaging and functional assays (e.g. contractility electrophysiology metabolism).

• Develop and utilize 2D and 3D cardiac model systems including multicellular cultures cardiac organoids and engineered cardiac tissues.

• Collaborate effectively across Bioscience and with other AstraZeneca functions to ensure successful delivery of project milestones.

• Present scientific data and insights at internal project teams and governance forums as well as external meetings.

• Leverage AI/ML-enabled approaches to extract insights from complex in vitro datasets contributing to data-driven target validation and decision making.

• Partner with data scientists and colleagues to implement AI-assisted workflows ensuring robust reproducible analysis and clear communication of findings.

• Actively contribute to a collaborative innovative environment sharing ideas and continuously improving ways of working.

• Depending on experience and personal interest take on opportunities to act as Target Leader and/or lead model development efforts.

Essential Skills/Experience

• PhD or Masters degree in Biology Pharmacology or a related discipline with a scientific background in cardiovascular disease

• Strong experience in cell and molecular biology biochemistry and relevant in vitro/ex vivo assays

• Minimum 2 years recent hands-on experience in handling and manipulating relevant PSC cells and primary human and animal cardiac cell types including cardiomyocytes

• Minimum 2 years recent hands-on experience in in vitro work within the cardiovascular field involving endothelial cells cardiomyocytes and fibroblasts in both healthy and diseased cardiovascular preclinical model systems

• Minimum 2 years recent hands-on experience in cardiac in vitro models: handson with 2D and 3D systems including cardiac organoids and engineered cardiac tissues across multiple cell types (e.g. hiPSCderived cardiomyocytes fibroblasts endothelial cells smooth muscle)

• Demonstrated interest and practical experience in applying AI/ML tools to support experimental design data interpretation and hypothesis generation

• A collaborative proactive and flexible mindset with the ability to work effectively in multidisciplinary teams

• Excellent scientific communication skills with strong written and spoken English

Desirable Skills/Experience

• Experience in drug discovery or development ideally within the pharmaceutical industry.

• Handson experience testing drug candidates or tool compounds in cardiac in vitro systems.

• Experience with in vivo and/or ex vivo cardiovascular models.

At AstraZeneca we are committed to making a difference. We have built our business around our passion for science. Now we are fusing data and technology with the latest scientific innovations to achieve the next wave of breakthroughs. Our inclusive environment allows us to work seamlessly together leveraging our diverse global knowledge to create the greatest impact on disease. Here you can grow your career while contributing to life-changing medicines.

Ready to make a difference Apply now!

Welcome with your application by May 17th 2026.

Date Posted

Closing Date