Sr. Scientist, Imaging

Job Title: Sr. Scientist Imaging

Location: Hamilton Ontario

Onsite 5 days/week

Description:

Fusion Pharmaceuticals part of the AstraZeneca Group is redefining precision oncology with nextgeneration radioconjugates that deliver powerful alphaemitting payloads directly to tumors. Our pipeline spans multiple firstinclass programsbacked by a GMPcompliant brand new radiopharmaceutical facility in Hamilton were turning groundbreaking science into realworld impact for patients. Join us at the forefront of radiopharma innovation and be part of turning breakthrough science into meaningful outcomes for patientscome build whats next with us!

The Role:

As Sr. Scientist Imaging this role is for an experienced preclinical imaging scientist to join the In Vivo Pharmacology team within AstraZenecas Radioconjugate Discovery Group. The successful candidate will provide strategic and technical expertise in the conception design execution and interpretation of preclinical imaging studies. A critical component will be the integration of nuclear imaging methodologies with pharmacology and ex vivo readouts to provide decision-enabling insights across Discovery activities including candidate screening and selection mechanism of action dosimetry and biomarker discovery.

Responsibilities:

• Design conduct and analyze imaging-based biodistribution and mechanistic studies of radiopharmaceuticals in rodent models of cancer (or other disease indications of interest) to enable decision-making data packages for go/no-go decisions. Perform reconstruction and quantification of multimodal imaging data
• Drive the development and implementation of imaging-based methods to explore dosimetry and PK/PD relationships as they relate to mechanism of action across our therapeutic pipeline. Integrate results with ex vivo tissue biodistribution and efficacy studies
• Build positive relationships with cross-functional experts align collaborators and clearly communicate plans and results to teams and governance
• Develop and expand internal preclinical imaging capabilities and spearhead the incorporation of nuclear imaging modalities into AstraZenecas Radioconjugate Discovery experimental workflow.
• Align nuclear medicine imaging protocols including review of parameters for QC image acquisition and reconstruction radiation dose determination and protocol dose management
• Coordinate the maintenance calibration and operation of brand new PET/SPECT/CT/MRI/Optical imaging equipment
• Mentor and train junior scientists on image acquisition reconstruction and analysis
• Produce high quality and well documented data with strong attention to detail
• Contribute to internal project teams through the setting and achievement of scientific goals communication of results and solving multifaceted scientific challenges
• Other duties as required

Qualifications:

• Ph. D (Biochemistry Biology Immunology Biomedical Engineering Medical physics Molecular/Cell Biology or related field) or Masters with 7-10 years of relevant experience
• 36 years of hands-on preclinical in vivo imaging in mouse models demonstrating expertise in PET/SPECT and at least one of MRI or CT
• Experience with in vivo mouse solid tumor models including IV injections tumor implantation and tissue collections
• Proficiency with analysis tools (PMOD VivoQuant 3D Slicer Amide) and scripting (Python/MATLAB/R) for automation and reproducibility
• Expertise with the operation of nuclear imaging equipment including software image reconstruction analysis and quantification of nuclear imaging data
• Ability to adapt to perform and develop unfamiliar methods in a rapidly evolving research environment
• Solution-oriented and effective team player in a multi-disciplinary setting with the ability to communicate with colleagues at all levels
• Experience with the safe handling of radioactive and biohazardous materials

Desirable skills/ experience:

• Theranostic strategy experience and preclinical dosimetry modeling
• Proficiency in quantitative image analysis and statistics and integration with ex vivo and PK/PD datasets
• Experience evaluating radioconjugates in solid tumors (antibody- peptide- or small-moleculebased) including isotope/chelator selection and labeling parameters impacting in vivo behavior.
• Biotech or pharmaceutical experience is an asset

Great People want to Work with us! Find out why:

• GTAA Top Employer Award for 11 years
• Top 100 Employers Award
• Canadas Most Admired Corporate Culture
• Learn more about working with us in Canada
• View our YouTube channel

Are you interested in working at AZ apply today!

AstraZeneca is an equal opportunity employer that is committed to diversity and inclusion and providing a workplace that is free from discrimination. AstraZeneca is committed to accommodating persons with disabilities. Such accommodation is available on request in respect of all aspects of the recruitment assessment and selection process and may be requested by emailing.

AstraZeneca is committed to providing fair and equitable compensation opportunities to all colleagues. Our compensation policies and practices have been designed to allow colleagues to progress through the salary range over time as they progress in their role. The range provided in this posting represents an offer pay range used in a majority of situations. The base pay offered will vary depending on multiple individualized factors including the candidates skills and experience job-related knowledge and other specific business and organizational some cases offers outside the range may also be considered to address unique circumstances.

In addition our permanent positions offer an annual Variable Pay Bonus/Short Term Incentive opportunity as well as eligibility to participate in our equity-based long-term incentive program (if applicable to role). Benefits offered for permanent roles include a competitive Flex Benefits & Retirement Savings Program 4 weeks paid vacation and annual Personal Days. Fixed Term Contract/Temporary positions (excluding students) are offered a Contract Benefits Program.

We are using AI as part of the recruitment process.

This advertisement relates to a current vacancy.