Scientist, Research Histologist
Job Location:
Waltham, MA - USA
Monthly Salary:
Posted on:
Vacancies:
Job Summary
Scientist Research Histologist
Responsibilities
Performendtoendhistology processing of tumor and normal tissues from mouse xenograft studies including tissue trimming paraffin embedding microtomy routine histochemical staining immunohistochemical (IHC)on validated automated staining platforms and archival offormalinfixedparaffinembedded(FFPE) samples
Work collaboratively within vivoscientists to provide study-aligned histology endpoints as follows:
Characterize new tumor models including disseminated models of hematologic cancers and patient-derived xenografts (PDXs) and models from drug-resistant patients and conditions
Use IHC-based endpoints with established markers to support pharmacokinetics/pharmacodynamics (PK/PD) and efficacy studiesin mouse models following therapeutic drug testing
Participate in general laboratory maintenance including buffer preparation reagent restocking and basic equipment upkeep
Data documentation and reports:
Digitally archive slides using the Leica Aperioor similarplatform
Accession FFPE samples into a digital specimen database and file blocks in designated storage tomaintainretrievability
Summarizeand present findings to project teamsand capture complete records inanelectronic laboratory notebook (ELN)in a timely manner
Education QualificationsSkillsand Experience
Essential Requirements
BS or MS in Biology or related discipline withat least2 years of experience in a histopathology laboratory
Experience and competency in performing routine histology procedures including trimming embedding microtomy and staining tissues
Strong organizational skills and attention to detail applied tolaboratory responsibilities data recordingand transparent reporting to project teams
Desirable Skills/Qualifications
Experience developingoptimizing and validating IHC assays includingantigenretrievaland titeroptimization and documentation of performance characteristics
Experience using image analysis platforms such as Indica Labs HALO for quantitative analysis of IHC endpoints
Histotechnician(HT) or Histotechnologist (HTL)(ASCP) certification
At AstraZeneca we push the boundaries of science to change the practice of medicine and transform the lives of patients living with cancer. With one of the broadest and deepestImmunologypipelines in the industry there are many opportunities to work with new and novel drugs. Our collaborative environment empowers us to take smart risks challenge the norm and learn from failures. We are united in our vision toeliminatecancer as a cause of death making bold moves that truly improve patient outcomes.
Join us in our mission to make a meaningful difference for patients around the world!
The annual base pay for this position ranges from $92252.00 - $138378.00. Our positions offer eligibility for various incentivesan opportunity to receive short-term incentive bonuses equity-based awards for salaried roles and commissions for sales offered include qualified retirement programs paid time off (i.e. vacation holiday and leaves) as well as health dental and vision coverage in accordance with the terms of the applicable plans.
Date Posted
28-Apr-2026Closing Date
15-May-2026Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and furtherance of that mission we welcome and consider applications from all qualified candidates regardless of their protected characteristics. If you have a disability or special need that requires accommodation please complete the corresponding section in the application form.
Required Experience:
IC
About Company
AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, ... View more
