Director, Screening Platform Technology

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The companys R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The companys RAS(ON) inhibitors daraxonrasib (RMC-6236) a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291) a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805) a RAS(ON) G12D-selective inhibitor; and RMC-5127 a RAS(ON) G12V-selective inhibitor are currently in clinical development. As a new member of the Revolution Medicines team you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

We are seeking an experienced Director of Screening Platform Technology to lead a multidisciplinary team responsible for the design execution and evolution of Revolution Medicines screening platforms. This role will oversee assay operations new process implementation and screening analytics and controls and will partner closely with software engineers automation engineers and a cross-functional screening strategy taskforce. The successful candidate will bring strong people leadership deep experience in high-throughput screening platforms and direct technical expertise in screening analytics and data-driven experimental design.

• Lead and develop a team of approximately 710 scientists and technical staff across assay operations new process implementation and screening analytics and controls.

• Provide strategic and technical leadership for HTS platform development in close partnership with software engineering automation engineering and cross-functional stakeholders.

• Own the end-to-end screening platform ensuring robust integration of robotics instrumentation software and data pipelines.

• Drive adoption of advanced screening analytics including quality control frameworks longitudinal analysis across campaigns and AI-enabled or data-driven experimental design.

• Serve as a technical thought partner to discovery teams translating scientific questions into effective screening strategies and interpretable data outputs.

• Establish best practices for screening data integrity reproducibility and insight generation.

• Serve as the primary point of contact for cross-functional partners ensuring timely and accurate delivery of materials.

• Work closely with the Director of Sample Management to communicate capacity risks and resource needs.

• Support onboarding and ramp-up of new staff and technologies within the laboratory.

Required Skills Experience and Education:

• Bachelors degree in Chemistry or a related field with a minimum of 8 years of relevant experience Masters degree with at least 6 years of relevant experience or Ph.D. with a minimum of 5 years of relevant experience; a combination of direct and related industry experience is preferred.

• Demonstrated success leading and developing multidisciplinary teams including experience managing sub-team leads or senior contributors.

• Extensive experience designing implementing and operating HTS platforms in collaboration with automation and software engineering teams.

• Direct hands-on expertise in screening data analytics including statistical analysis controls longitudinal data analysis and experimental design.

• Experience applying or evaluating machine learning or AI-driven approaches to screening strategy and data interpretation.

• Strong systems-level thinking with the ability to balance innovation with pragmatic delivery of results.

• Excellent written and verbal communication skills.

Preferred Skills:

• Experience shaping or modernizing screening platforms in a growing discovery organization.

• Familiarity with scalable data and analytics frameworks for screening and discovery.

• Oncology or small-molecule drug discovery experience.

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