Automation Engineer

Ready to redefine whats possible in molecular diagnostics

Join a team of brilliant passionate innovators determined to transform healthcare. At BillionToOne weve built a category-defining publicly traded company on Nasdaq where transparency fuels trust collaboration drives breakthroughs and every contribution moves the needle on our mission to make life-changing diagnostics accessible to all. We dont just aim for incremental improvements; we build products that are 10x better than anything that exists today.

Our scientists engineers sales executives and visionaries are united by an unwavering commitment to changing the standard of care in prenatal and cancer diagnostics. This is where cutting-edge science meets human compassion and every innovation you contribute helps remove the fear of the unknown from some of lifes most critical medical moments.

If youre driven by purpose energized by innovation and ready to help shape the future of precision medicine at scale this is where you belong.

Automation Engineer BillionToOne Inc. Menlo Park CA. Lead the development optimization and implementation of automated workflows for genomic DNA extraction NGS library preparation and other molecular biology techniques; Design and integrate custom Python-based solutions to enhance liquid handler and LIMS interactions; Manage and improve service tracking systems for CLIA production instruments; Collaborate with R&D and clinical teams to scale up new assays and transfer them to automated platforms; Independently design experiments and analyze data; and Provide technical advice and mentoring to junior team members.

Requirements: Bachelors degree in Engineering Physics Chemistry Chemical Biology Computational Biology Automated Science or a related field is required and 3 years experience as a Clinical Laboratory Automation Specialist Assay Development Automation Engineer Molecular Diagnostics Automation Specialist NGS Workflow Engineer or related. Must also possess: 3 years experience in laboratory automation preferably in a clinical or diagnostic setting; 3 years experience in independent execution of projects for high-throughput diagnostic assay scale-ups; 3 years experience in liquid handling platforms (e.g. Hamilton Beckman Biomek Agilent Bravo); 3 years experience in next-generation sequencing (NGS) workflows and library preparation; 3 years experience in conducting independent data analysis/computational tasks; 3 years experience with scheduling software such as Biosero Green Button Go or PAA Overlord; 3 years experience with programming in Python R and bash; 3 years experience with CLIA and CAP regulations; and 3 years experience in optimizing automated workflows for increased efficiency and yield. Must successfully complete competency-based interview.

ALTERNATE REQUIREMENTS: Masters degree in Engineering Physics Chemistry Chemical Biology Computational Biology Automated Science or a related field is required and 1 year of experience as a Clinical Laboratory Automation Specialist Assay Development Automation Engineer Molecular Diagnostics Automation Specialist NGS Workflow Engineer or related. Must also possess: 1 year of experience in laboratory automation preferably in a clinical or diagnostic setting; 1 year of experience in independent execution of projects for high-throughput diagnostic assay scale-ups; 1 year of experience in liquid handling platforms (e.g. Hamilton Beckman Biomek Agilent Bravo); 1 year of experience in next-generation sequencing (NGS) workflows and library preparation; 1 year of experience in conducting independent data analysis/computational tasks; 1 year of experience with scheduling software such as Biosero Green Button Go or PAA Overlord; 1 year of experience with programming in Python R and bash; 1 year of experience with CLIA and CAP regulations; and 1 year of experience in optimizing automated workflows for increased efficiency and yield. Must successfully complete competency-based interview.

Expected salary range is $121264.00-$140454.00/year. To apply send resume to

For more information about how we protect your information we encourage you to review our .

BillionToOne is a next-generation molecular diagnostics company on a mission to make powerful accurate diagnostic tests accessible to everyone. Our revolutionary QCT molecular counting technology enhances disease detection resolution by over a thousandfold using cell-free DNAa breakthrough that has already transformed the lives of over half a million patients worldwide.

Our Impact

Unity Complete is the only non-invasive prenatal screen capable of assessing fetal risk for both common recessive conditions and aneuploidies from a single maternal blood sample. Our Northstar liquid biopsy test uniquely combines treatment selection with real-time monitoring giving oncologists unprecedented precision in cancer care.

Our Growth

From $0 to $150M in Annual Recurring Revenue in just five 2025 we completed one of the most successful IPOs for a medical diagnostics company building on nearly $400M in private fundingincluding our $130M Series D in 2024 and backed by world-class investors including Hummingbird Adams Street Partners Neuberger Berman Baillie Gifford and Premji Invest.

Our Recognition

Forbes named us one of Americas Best Startup Employers for 2025 and were Great Place to Work certified with 100% of our people willing to go the extra mile even as weve scaled to over 700 employees.

Our Future

Headquartered in Menlo Park with facilities in Union City CA and a new lab opening in Austin TX in 2027 were continuing to push the boundaries of whats possible in molecular diagnostics. Were just getting started.

Ready to help us change the world one molecule at a time Learn more at