Postdoctoral Fellow-MSH
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Job Location:
New York City, NY - USA
Monthly Salary:
Not Disclosed
Posted on:
22 hours ago
Vacancies:
1 Vacancy
Job Summary
Title: Human Induced Pluripotent Stem Cell-Derived Brain Organoid Model of Congenital Disorders of Glycosylation (CDG)
Salary: standard post-doctoral salary
Department: Genetics and Genomic Sciences
Physical work location: 1425 Madison Ave New York NY 10029; Icahn Building; Floor 14.
Name PI or Supervisor: Tamas Kozicz; ; and Eva Morava-Kozicz; ;
Web link to Lab: n/a
Web link to Department: of Research Project:
As a Post-Doctoral Research Fellow in the Morava-Kozicz lab you will engage in cutting-edge research aimed at unraveling the complex relationship between changes in structure and function metabolic repercussions and the brain phenotype observed in individuals with Congenital Disorders of Glycosylation (CDG). This position offers a unique opportunity to contribute to the identification of new therapeutic approaches to alleviate or reverse this debilitating condition. The project encompasses a diverse array of techniques including molecular biology viral vector technology cell culture in vitro multi-electrode array recordings immunohistochemistry and advanced imaging methods.
Technical Duties:
Main responsibilitiesin thisresearchare designing and conducting studies that encompass a range of techniques including molecular biology and viral vector technologies cell culturing in vitro multi-electrode array recordings immunohistochemistry and advanced imaging methodologies. Youare expectedtobeon dutyforapproximately 37.5 hours perweek.
Qualifications
Educational and other Requirements for the position:
Ph.D. M.D. or M.D. Ph.D. degree with a robust background in relevant disciplines.
Experience Required:
- Demonstrated laboratory experience with a notable record of first-author publications demonstrating excellence in both written and oral communication.
- High motivation and the ability to work independently as well as collaboratively within a dynamic research team.
- Prior experience in genetics or metabolism research is desirable.
- Familiarity with induced pluripotent stem cell (iPSC)-derived disease models is advantageous.
Goals/Outcomes of the Research Project:
- Advancement in Understanding CDG Pathophysiology:Through rigorous research efforts we anticipate gaining deeper insights into the intricate interplay between altered brain development metabolic consequences and the central nervous system phenotype observed in individuals with CDG. This enhanced understanding will contribute to the broader comprehension of CDG pathophysiology potentially uncovering novel targets for therapeutic intervention.
- Identification of Therapeutic Targets: By employing a multidisciplinary approach encompassing molecular biology viral vector technology cell culture electrophysiology immunohistochemistry and advanced imaging methodologies we aim to identify specific metabolic alterations driving the brain pathology in CDG. These findings hold promise for the development of targeted therapeutic interventions aimed at alleviating or reversing the debilitating symptoms associated with CDG.
- Publication of Research Findings: We anticipate the publication of high-impact research findings in peer-reviewed journals highlighting our contributions to the field of CDG research. These publications will serve to disseminate our discoveries to the scientific community fostering further collaboration and exploration in the realm of CDG pathophysiology and therapeutic development.
- Contribution to Professional Development: The postdoctoral research fellow will have the opportunity to further develop their skills and expertise in a supportive and collaborative research environment. Through mentorship from esteemed faculty members and hands-on experience with state-of-the-art techniques the fellow will enhance their professional repertoire paving the way for future success in academia or industry.
- Advancement of CDG Research Community: Our research endeavors aim to contribute to the advancement of the CDG research community by fostering collaboration sharing knowledge and engaging in dialogue with fellow researchers and clinicians. By actively participating in conferences seminars and workshops we seek to disseminate our findings exchange ideas and inspire further investigation into CDG pathophysiology and therapeutic strategies.
816 - Genetics/Genomic Sci - ISM Icahn School of Medicine
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