Therapeutic Area Biomarker LeadBiomarker Strategy – Cardiovascular and Metabolism
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Job Location:
Basel - Switzerland
Monthly Salary:
Not Disclosed
Posted on:
Yesterday
Vacancies:
1 Vacancy
Job Summary
Job Description Summary
As a Cardiovascular and Metabolism (CVM) Therapeutic Area Biomarker Lead (TABL) (Director) you will lead the CVM disease area biomarker matrix team and be responsible for the development and implementation of fit for purpose biomarker strategies and providing an effective interface for transitioning projects from early to later stage clinical development. You will be a core member of CVM clinical project teams engaged in Translational Data Science teams and provide therapeutic area line function review for clinical protocols. As a TABL you will lead efforts to identify develop and drive disease mechanistic and compound biology that serves the clinical and precision medicine approaches for the multi-indication CVM portfolio that focuses on heart failure atherosclerosis obesity and atrial fibrillation indications.Job Description
#LI-Hybrid
This hybrid role can be based in Basel Switzerland or London UK.
For US posting please refer to REQ-
Key Responsibilities:
Delivering clinical project and disease biomarker strategies and plans across the early through late phase within the Cardiovascular and Metabolism portfolio and support relevant mature assets in the late phase portfolio
Leading a dedicated matrixed group of Subject Matter Experts and project team representatives as well as key program stakeholders to together develop biomarkers strategies for disease and/or assets across the Research-Development-Commercial continuum
Representing Biomarker Development on Cardiovascular and Metabolism early and late Disease Area Decision Boards to identify develop and drive cardiovascular and metabolic disease and compound mechanistic biology and precision medicine approaches for the portfolio
Leading strategic translational data working groups centered on integrating and analyzing large-scale patient muti-modal data sets (omics imaging digital etc.) to identify new indications endpoints and responsive patient subpopulations
Representing BMD line functions in Therapeutic Area Line Function committees for clinical protocol development and operational milestone reviews
Leading biomarker strategies and drive plans at the clinical team level as a Biomarker Strategy Lead
Lead and/or contribute to BMD/TM/BR wide initiatives e.g. genetics inflammation imaging depending on background and expertise
Stay up to date on clinical disease biology and scientific literature and competitor data for their respective disease areas
Implementing strategies in close collaboration with the BMD global organization which includes over 150 associates with expertise in all aspects of biomarker science i.e. genetics genomics molecular and cellular digital devices imaging and data sciences
Design and present the RDC biomarker strategy for transitioning and mature assets for late phase within their key pillar and ensuring study level alignment across the portfolio segment of focus
Essential Requirements:
MD MD/PhD or PhD degree required plus additional PhD/postdoc or equivalent level research
Deep understanding of cardiovascular and metabolic disease epidemiology with particular emphasis on Atherosclerotic Cardiovascular Disease (ASCVD) that can be applied to questions of diagnosis biomarker development and treatment monitoring strongly preferred
Scientific excellence supported by recognized high quality publications; clinical and/or biological expertise in cardiovascular and metabolic diseases (Board certified or similar level preferred) with impact in ASCVD literature
5 plus years of independent leadership experience and external leadership/partnership in consortia and/or health authority initiatives
Proven success in leading and partnering in multidisciplinary matrix teams across Pharma/biotech (clinical research thru healthcare applications) academic institutions or commercial business functions including a mature biomarker strategy to support registration and/or launch
Demonstrated ability to own an entire section of the portfolio as well as the phase package; Well-developed interpersonal skills with good presence and ability to influence and negotiate with senior leadership; experienced presenter and communicator
Significant relevant experience after your MD/PhD/postdoc including quantitative expertise in biostatistics bioinformatics computer biology statistical genetics clinical imaging machine learning or data science; interpreting and publishing studies consisting of omics data e.g. genetics genomics proteomics; closely partnering with/leading data scientists
Fluent in oral and written English; other languages e.g. German French Italian useful but not required
** Final job title Associate Director (level 5) or Director (level 6)and associated responsibilities will be commensurate with the successful candidates level of expertise.
Novartis is committed to building an outstanding inclusive work environment and diverse teams representative of the patients and communities we serve.
Accessibility and Accommodation:
Switzerland
Accessibility and accommodation
Novartis is committed to working with and providing reasonable accommodation to all individuals. If because of a medical condition or disability you need a reasonable accommodation for any part of the recruitment process or in order to receive more detailed information about the essential functions of a position please send an e-mail to and let us know the nature of your request and your contact information. Please include the job requisition number in your message.
Skills Desired
Accountability Chemical Biology Clinical Research Clinical Trials Collaboration Communication Skills Decision Making Drug Development Drug Discovery Immunology Influence Influencing Skills Leadership Lifesciences Management Medical Research Mentorship Molecular Biology Presentation Skills Stakeholder Engagement Stakeholder Management Strategic Thinking Team Management Well-Being
Key Skills
About Company
Novartis is a global healthcare company based in Switzerland that provides solutions to the evolving needs of patients worldwide.
