Modelling and Simulations Scientist ( 2 year contract)

At Roche you can show up as yourself embraced for the unique qualities you bring. Our culture encourages personal expression open dialogue and genuine connections where you are valued accepted and respected for who you are allowing you to thrive both personally and professionally. This is how we aim to prevent stop and cure diseases and ensure everyone has access to healthcare today and for generations to come. Join Roche where every voice matters.

The Position

At Roche we believe its urgent to deliver medical solutions right now even as we develop innovations for the future. We are passionate about transforming patients lives and we are fearless in both decision and action. We commit ourselves to scientific rigor unassailable ethics and access to medical innovations for all.

Roche Pharma Research and Early Development (pRED) translates extraordinary science into medical innovation through a diversity of technologies and talent. The translational Modelling and Simulation (tM&S) capability part of the Predictive Modeling (PM) Chapter aims to enhance understanding of disease biology and inform the selection of the right molecules for development.

We are looking for a scientist to support early research and development with mathematical modeling. This role requires a candidate with a strong mathematical background and a pragmatic approach to drug development. You will design innovative quantitative approaches to predict clinical efficacy and safety integrating pharmacological and toxicological data to ensure the optimal conduct of clinical studies.

The Opportunity

Your mission will be to conduct modelling and simulation activities at the project level through the development of quantitative physiology/mechanism-based and drug-disease models. You will:

• Develop multi-scale models for PK efficacy and toxicology by integrating experimental data (in vitro in vivo and omics) and literature-based evidence.

• Build complex quantitative systems pharmacology (QSP) models such as mechanistic tumor-site interaction models for small molecules to predict drug disposition and target attainment.

• Apply mechanistic insights to characterize drug accumulation and PK/PD relationships including the impact of lysosomal trapping and binding dynamics.

• Extend modeling frameworks to areas such as combination therapies antibody drug conjugates and antibiotic PK/PD.

• Design and deploy interactive tools specifically using R and Shiny applications to facilitate model exploration and guide internal decision-making.

• Leverage AI and Machine Learning to enhance predictive accuracy automate data integration and explore high-dimensional biological datasets.

• Perform rigorous parameter estimation through Bayesian methods and stochastic modeling techniques to extend deterministic frameworks.

• Communicate results quickly and effectively to project teams and senior management ensuring M&S activities align with overall project goals and Roche standards.

Who you are

• A PhD-level degree in natural sciences mathematics physical sciences or engineering is required.

• Advanced programming skills in R and Python with a proven ability to code quickly and with high rigor are required.

• Extensive experience in mechanistic modeling is required.

• A strong mathematical foundation applied to drug discovery with the ability to put complex results into the perspective of the drug development process is required.

• An independent thinker with high creativity and a track record of scientific excellence is required.

• Strong lead author history of publications and a history of effective scientific communication both inside and outside the company is required.

• Inclusive mindset and the ability to interact effectively with pharmacology scientists project leaders and experimental collaborators.

• Growth mindset characterized by curiosity and a willingness to learn and go beyond standard solutions and methods.

• Willingness to speak up bring different perspectives and lead consultants or outside collaborators effectively.

• Proactive attitude that takes initiative proposes solutions and maintains a can-do approach to complex scientific challenges.

• Independent thinker with a track record of scientific excellence and a strong lead author history of publications.

The next step is yours. To apply today click on the Apply online button.

Who we are

A healthier future drives us to innovate. Together more than 100000 employees across the globe are dedicated to advance science ensuring everyone has access to healthcare today and for generations to come. Our efforts result in more than 26 million people treated with our medicines and over 30 billion tests conducted using our Diagnostics products. We empower each other to explore new possibilities foster creativity and keep our ambitions high so we can deliver life-changing healthcare solutions that make a global impact.

Lets build a healthier future together.

Roche is an Equal Opportunity Employer.