Principal Research Scientist II, siRNA

Worcester, MA - USA

Monthly Salary: Not Disclosed

Posted on: Yesterday

Vacancies: 1 Vacancy

Job Summary

The Biotherapeutic and Genetic Medicine (BGM) team at AbbVie is seeking an accomplished Principal Research Scientist to lead the overall strategy for a group and multi-disciplinary project this role you will establish a high-throughput siRNA screening platform drive pipeline innovation through next-generation delivery modalities and deliver therapeutic leads across multiple disease areas.

Responsibilities:

Strategy: Define and drive the multi-year roadmap for the siRNA screening platform ensuring alignment with therapeutic goals in neuroscience oncology and immunology. Collaborate with key stakeholders to balance resources between platform-building and pipeline-driving.
Execution: Oversee the transition of manual assays into robust automated high-throughput screening (HTS) workflows to identify high-potency siRNA leads. Act as the primary contact between Discovery and Development Sciences (DMPK Tox and CMC) to ensure seamless molecule transition and scale-up readiness.
Innovation: Design and evaluate next-gen delivery modalities specifically Antibody Oligonucleotide Conjugates (AOCs) and tissue-specific ligand conjugates utilizing advanced chemical modification patterns. Establish fast-fail in vivo screening models to rapidly validate functional siRNA delivery to extrahepatic tissues.
Leadership: Build lead and develop a high-performing team of 10 scientists fostering a culture that is collaborative agile and courageous while managing laboratory infrastructure to maximize throughput.

Qualifications :

BS MS or PhD in Molecular Biology Biochemistry Chemistry or a related field with typically 8 (PhD) 14 (MS) or 16 (BS) years of industry experience in biotech or pharma and at least 5 years in a leadership/management role.
Proven track record in siRNA design and the application of chemical modifications for stability and hands-on experience with automation platforms and HTS data analysis.
Previous experience leading siRNA platform or portfolio programs targeting tissues beyond the liver is strictly required.
Demonstrated ability to advise discipline experts and functional leaders on identifying and mitigating technical and strategic risks.
Exceptional interpersonal skills with a proven ability to maintain productive working relationships with diverse internal teams and external collaborators.
A strong track record of presenting complex scientific data to internal and external stakeholders.

Additional Information :

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:

The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location and we may ultimately pay more or less than the posted range. This range may be modified in the future.
We offer a comprehensive package of benefits including paid time off (vacation holidays sick) medical/dental/vision insurance and 401(k) to eligible employees.
This job is eligible to participate in our short-term incentive program.
This job is eligible to participate in our long-term incentive program.

Note: No amount of pay is considered to be wages or compensation until such amount is earned vested and determinable. The amount and availability of any bonus commission incentive benefits or any other form of compensation and benefits that are allocable to a particular employee remains in the Companys sole and absolute discretion unless and until paid and may be modified at the Companys sole and absolute discretion consistent with applicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity driving innovation transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

US & Puerto Rico only - to learn more visit & Puerto Rico applicants seeking a reasonable accommodation click here to learn more:

Work :

Employment Type :

Full-time

Responsibilities:

Strategy: Define and drive the multi-year roadmap for the siRNA screening platform ensuring alignment with therapeutic goals in neuroscience oncology and immunology. Collaborate with key stakeholders to balance resources between platform-building and pipeline-driving.
Execution: Oversee the transition of manual assays into robust automated high-throughput screening (HTS) workflows to identify high-potency siRNA leads. Act as the primary contact between Discovery and Development Sciences (DMPK Tox and CMC) to ensure seamless molecule transition and scale-up readiness.
Innovation: Design and evaluate next-gen delivery modalities specifically Antibody Oligonucleotide Conjugates (AOCs) and tissue-specific ligand conjugates utilizing advanced chemical modification patterns. Establish fast-fail in vivo screening models to rapidly validate functional siRNA delivery to extrahepatic tissues.
Leadership: Build lead and develop a high-performing team of 10 scientists fostering a culture that is collaborative agile and courageous while managing laboratory infrastructure to maximize throughput.

Qualifications :

BS MS or PhD in Molecular Biology Biochemistry Chemistry or a related field with typically 8 (PhD) 14 (MS) or 16 (BS) years of industry experience in biotech or pharma and at least 5 years in a leadership/management role.
Proven track record in siRNA design and the application of chemical modifications for stability and hands-on experience with automation platforms and HTS data analysis.
Previous experience leading siRNA platform or portfolio programs targeting tissues beyond the liver is strictly required.
Demonstrated ability to advise discipline experts and functional leaders on identifying and mitigating technical and strategic risks.
Exceptional interpersonal skills with a proven ability to maintain productive working relationships with diverse internal teams and external collaborators.
A strong track record of presenting complex scientific data to internal and external stakeholders.

Additional Information :

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:

The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location and we may ultimately pay more or less than the posted range. This range may be modified in the future.
We offer a comprehensive package of benefits including paid time off (vacation holidays sick) medical/dental/vision insurance and 401(k) to eligible employees.
This job is eligible to participate in our short-term incentive program.
This job is eligible to participate in our long-term incentive program.

AbbVie is an equal opportunity employer and is committed to operating with integrity driving innovation transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

US & Puerto Rico only - to learn more visit & Puerto Rico applicants seeking a reasonable accommodation click here to learn more:

Work :

Employment Type :

Full-time

Key Skills

Machine Learning
Python
Data Science
AI
R
Research Experience
Sensors
Drug Discovery
Research & Development
Natural Language Processing
Data Analysis Skills
Toxicology Experience

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About Company

AbbVie

AbbVie is a global biopharmaceutical company focused on creating medicines and solutions that put impact first for patients, communities, and our world. We aim to address complex health issues and enhance people's lives through our core therapeutic areas: immunology, oncology, neuro ... View more

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