Senior Scientist – Medicinal Chemistry, Oncology Targeted Discovery
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Job Location:
Waltham, MA - USA
Monthly Salary:
$ 118870 - 178306
Posted on:
Yesterday
Vacancies:
1 Vacancy
Job Summary
Senior Scientist Medicinal Chemistry Oncology Targeted Discovery
Location: Waltham MA US
Do you want to be at thecutting edgeof innovation that will lead tostate-of-the-arttherapies for cancer At AstraZeneca we turn ideas into life changing medicines. Our pioneering oncology pipeline enabled by transformative technologies drives us forward. Working here means being ambitious thinkingbigand working together to make the impossible a reality for patients.
This Opportunity
As a Senior Scientist within the Oncology TargetedDiscovery (OTD) chemistry groupyoullplayan important roleinadvancing new oncology drug projects to make a positive impact on patients is a hands-on laboratory position within a world leading global medicinal chemistry groupandpart of an important strategy to deliver highly specifictherapeuticsincludingsmallmoleculespeptideand antibody drug conjugates with various targeting modalities to treat cancer.
In addition to our passion for the discovery of innovative new medicines we understand the importance of flexibility in our work-life environment and we offer a wide variety of benefits services and programs that provide ouremployeeswiththe resources they need to pursue not only their work goals but also their life goals. We are dedicated to building strong research teams that embrace the diversity of talents of team members and allow the larger group to grow and learn together toaccomplishour collective goal to improve human health.
Responsibilities:
Design and execute synthetic routes topreparecomplex target moleculesfortumor-targeted deliveryprograms.
Developcreative approachesto overcome challenging synthetic chemistry problems.
Analyzedataand interpretstructureactivity relationships (SAR)torationallydesignnewtargets.
Work both independently and as a team member collaboratingwith colleagues across drug discovery functions includingcomputational chemistryandhigh-throughput experimentation.
Contribute topatent applicationsand scientific publications.
Stay current withnew developments insynthetic organic chemistryandmedicinal chemistry.
Actin accordance withallAstraZeneca policies including personnel guidelinesEHS regulations best laboratory practices and theCode of Conduct.
Essential Requirements:
Doctoral degree (Ph.D.) or equivalent focused in synthetic organic chemistrywith0 years of relevant experience.
Astrongtrack recordof scientific innovation and success documented through peer-reviewed publications.
Expertknowledge oforganic synthesis andmethodology withsound understanding of reactionmechanisms and awareness of latest scientific literature.
Strong workethicand adherence to safe practices in the laboratory.
Desireto grow and develop as a synthetic/medicinal chemist.
Site Location
The Waltham R&D site is home toourOncology Targeted Discoverychemistryresearchin North America. It is situated within a biopharma cluster of academic research institutions medical centers pharmaceuticalcompaniesand biotech start-ups. The Boston region is consistently ranked #1 globally for biotech research investment talentrecruitmentand lab space.
The campus also known as the BostonBioHub is one of the largest and most dynamic life-science research hubs in the is home to more than 800 scientists and experts working in nine different pharmaceutical and biotech site is also home to the AstraZeneca Incubator a program that helpsemergingcompanies advance novel and innovative healthcare solutions to meet the needs of patients. Plenty of free covered/uncovered parking is available along with charging stations for electric vehicles. Additionally shuttle service to local transportation hubs is also available.
As AstraZeneca continues to put patients at the forefront of our mission we are excited for our move to Kendall Square/Cambridge in2026.
Find out more information here: Kendall Square Press Release
Why AstraZeneca
At AstraZeneca we are dedicated to being aGreat Place to Work. A place where employees are empowered to push the boundaries of science and unleash their entrepreneurial spirit. There is no better place to make a difference to medicine patients and society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning growth and development.
So what is next
AstraZeneca is aplace built on courage curiosity and collaboration we make bold decisions driven by patient outcomes. Empowered to lead at every level free to ask questions and take calculated risks that write the next chapter for our pipeline. If you are swift to action confident to lead willing to collaborate and passionate about the possibilities then we are keen to hear from you!
The annual base pay for this position ranges from $118870 to $178306. Our positions offer eligibility for various incentivesan opportunity to receive short-term incentive bonuses equity-based awards for salaried roles and commissions for sales roles. Benefits offered include qualified retirement programs paid time off (i.e. vacation holiday and leaves) as well as health dental and vision coverage in accordance with the terms of the applicable plans.
Date Posted
16-Feb-2026Closing Date
01-Mar-2026Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and furtherance of that mission we welcome and consider applications from all qualified candidates regardless of their protected characteristics. If you have a disability or special need that requires accommodation please complete the corresponding section in the application form.
Required Experience:
Senior IC
Key Skills
- Laboratory Experience
- Mammalian Cell Culture
- Biochemistry
- Assays
- Protein Purification
- Research Experience
- Next Generation Sequencing
- Research & Development
- cGMP
- Cell Culture
- Molecular Biology
- Flow Cytometry
About Company
AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, ... View more
