Research Associate – ProteomicsDrug Target Validation
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Job Location:
Boston, NH - USA
Monthly Salary:
Not Disclosed
Posted on:
22 hours ago
Vacancies:
1 Vacancy
Job Summary
Overview
Monte Rosa Therapeutics is seeking to recruit a highly motivated research associate to join its Proteomics group in Boston to support hit confirmation and drug target validation. This is an exciting opportunity to join a team responsible for identification and validation of novel molecular glue degrader targets. The lab-based position will focus on developing and running cell-based assays to validate hits from the companys proteomics-based screening platform. The candidate should exhibit excellent communication and collaborative skills for working on cross-functional multi-disciplinary drug discovery teams.
Responsibilities
- Support research efforts discovering and validating small molecule screening hits through development of cellular assays including target engagement ternary complex and degradation assays
- Collaborate with team members to design and execute experiments using routine molecular biology biochemistry and cell culture techniques including working with both immortalized and primary cell lines
- Assay optimization: identification and fine-tuning of critical assay parameters such as optimal gene expression levels seeding density timeframe or co-treatments
- Compile and analyze experimental data and communicate research findings at internal meetings
- Prepare and manage laboratory stocks of routinely used reagents
- Accurately document experimental details through timely maintenance of electronic lab notebook records and the development of standard operating procedures (SOPs) for new protocols
Qualifications
- BSc and/or MSc in Cell Biology Biochemistry or a related field with at least 2 years of relevant industry or academic research experience
- Proficiency in culturing mammalian cells and utilizing sterile techniques (ideally BSL2 standards)
- Hands-on experience with a variety of cell culture and cellular biochemistry techniques including at least several of the following: transfection lentiviral transduction cell line generation cell viability assays SDS-PAGE/Western blot immunoprecipitation/co-IP and flow cytometry
- Experience with cellular PPI target engagement ternary complex or degradation assays is preferred
- Critical and independent thinking strong analytical and problem-solving skills
- Highly collaborative and able to work in a matrix interactive and fast-paced drug discovery environment.
- Excellent oral and written communication skills to work in a collaborative matrix team
Required Experience:
IC
Key Skills
- Laboratory Experience
- ELISA
- Immunoassays
- Mammalian Cell Culture
- Biochemistry
- Cell Biology
- Research Experience
- Cell Culture
- Molecular Biology
- Microscopy
- Research Laboratory Experience
- Western Blot
About Company
Pioneering Therapies for Cancer and Beyond – Our drug discovery platform is tailored to promote specific protein ubiquitination and subsequent proteasomal degradation of disease-causing, undruggable proteins, in essence leading to pharmacological protein knockout with high efficiency ... View more
