Senior Scientist, Protein and Structural Chemistry, Discovery Chemistry

Job Description

Are you ready to embark on an exhilarating career journey that combines innovation collaboration and impactful scientific discovery At our company a global leader in pharmaceuticals renowned for excellence and groundbreaking research we are committed to improving lives through innovative medicines vaccines and animal health products.

Protein and Structural Chemistry (PSC) a team in Discovery Chemistry (DC) supports protein structural determination from Discovery to Development agnostic to therapeutic modalityincluding small molecule peptide and macromolecules. Furthermore we elucidate the structural basis of mechanisms of action and perform analyses to support formulation development. PSC is a team of approximately 40 structural biologists who collaborate closely with medicinal and computational chemists informaticians mass spectrometrists biophysicists protein scientists and pharmacologists to leverage state-of-the-art capabilities to drive drug design and development.

We are seeking a creative self-motivated structural biologist with exceptional interpersonal and problem-solving skills to join our growing PSC group. The successful candidate must have expertise in cryo-electron tomography (CryoET) and either X-ray crystallography Cryo-EM or microED and will be responsible for all aspects of the experimental process from sample preparation and data collection through data processing structure determination and the effective communication of structural analyses with key stakeholders. The position requires active interaction with the external scientific community including presentations at external meetings and publication in peer reviewed journals. The successful candidate is expected to foster and contribute to a workforce where colleagues and partners feel comfortable bringing their unique perspectives to work.

This position will be located in our newly renovated labs and office spaces within our vibrant research campus in Rahway New Jersey our companys headquarters. Our new labs are equipped with three state-of-the-art microscopes including an Arctis FIB-SEM for preparation of samples for cryo-electron tomography a Glacios a Krios G4 instrumentation for Cryo-EM grid preparation access to multiple synchrotrons around the world and frequent regular access to the IMCA-CAT beamline and crystallization equipment and automation.

Productive and collaborative interactions with other members of our cross-functional department are required in this role. Inclusive and collaborative use of internal expertise and resources will be essential to success.

There is an expectation for periodic travel.

Required Experience and Skills:

• • Ph.D. in structural biology biochemistry cell biology or related field.

  • Demonstrated experience in a broad range of activities for CryoET including sample preparation cryo-FIB-milling data collection subtomogram averaging and segmentation workflows.

  • Demonstrated experience in another structural biology technique such as X-ray crystallography (including either crystallization screening and optimization crystal harvesting data collection and structure determination for X-ray crystallography) or CryoEM (including grid sample preparation data collection data processing and structure determination) or microED (including sample preparation data collection data processing and structure determination).

  • Excellent written and oral communication skills to facilitate team progress and ensure clarity on program status for therapeutic team and management are required.

  • Demonstrated strong organizational abilities with a proven track record of managing timelines effectively.

  • Ability to design and manage a research project.

  • Ability to prepare and publish peer-reviewed research.

Optional Experience and Skills:

• • Experience with cell culture and growth of cells on cryoEM grids.

  • Experience with processing and imaging tissue samples.

  • Experience with cryo-correlated light and electron microscopy (cryoCLEM) workflows for the identification of features of interest and targeted lamellae preparation.

  • Experience using gold labeling to identify regions of interest in cryoET samples.

  • Experience with structure determination of protein complexes bound to therapeutic molecules.

Required Skills:

Preferred Skills:

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Effective September 5 2023 employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week Monday - Thursday although the specific days may vary by site or organization with Friday designated as a remote-working day unless business critical tasks require an on-site Hybrid work model does not apply to and daily in-person attendance is required for field-based positions; facility-based manufacturing-based or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note this Hybrid work model guidance also does not apply to roles that have been designated as remote.

The salary range for this role is

This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employees position within the salary range will be based on several factors including but not limited to relevant education qualifications certifications experience skills geographic location government requirements and business or organizational needs.

The successful candidate will be eligible for annual bonus and long-term incentive if applicable.

We offer a comprehensive package of benefits. Available benefits include medical dental vision healthcare and other insurance benefits (for employee and family) retirement benefits including 401(k) paid holidays vacation and compassionate and sick days. More information about benefits is available at can apply for this role through (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting.

San Francisco Residents Only:We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance

Los Angeles Residents Only:We will consider for employment all qualified applicants including those with criminal histories in a manner consistent with the requirements of applicable state and local laws including the City of Los Angeles Fair Chance Initiative for Hiring Ordinance

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Merck & Co. Inc. Rahway NJ USA also known as Merck Sharp & Dohme LLC Rahway NJ USA does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place introductions are position specific. Please no phone calls or emails.

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