Senior Scientist to Principal Scientist, in vitro Biology

Job Title: Senior Scientist/Principal Scientist in vitro Biology

Reports To: Director Biology

Location: Shanghai China

About Us:

Structure Therapeutics develops lifechanging medicines for patients using advanced structurebased and computational drug discovery technology. The companys platform combines the latest advancements in visualization of molecular interactions computational chemistry and data integration to design orally available superior small molecule medicines that overcome current limitations of biologic and peptide drugs. We are advancing a clinicalstage pipeline of differentiated treatments focused on chronic diseases with high unmet need including cardiovascular metabolic and pulmonary conditions.

Structure Therapeutics is led by an experienced group of international drug innovators and financed by top-tier global life sciences investors. The company completed an initial public offering (IPO) in February 2023. With offices in California and Shanghai Structure Therapeutics has the benefit of being at the center of life science innovation in both the US and China and capitalizing on the strengths of each geographic location.

Position Summary:

We are seeking a Senior Scientist / Principal Scientist to lead and advance in vitro receptor pharmacology efforts across our internal drug discovery programs. This role will serve as a scientific owner for in vitro pharmacology capabilities supporting GPCR-focused programs in metabolic diseases including obesity and liver-related indications.

The successful candidate will bring deep expertise in either receptor pharmacology and/or metabolic disease biology with the ability and interest to bridge disciplines through close collaboration with cross-functional teams and external partners.

Job Responsibilities:

• Provide scientific leadership and ownership of in vitro receptor pharmacology strategies to support GPCR-driven drug discovery programs.
• Design develop and optimize receptor binding assays binding kinetics assays and receptor de-sensitization assays to enable compound profiling and decision-making.
• Establish and evolve in vitro pharmacology and biology competencies aligned with program platform needs.
• Drive a strong understanding of target and disease biology and integrate biological insights into assay design and data interpretation.
• Generate review and interpret high-quality pharmacology data from internal studies and CRO partners influencing project go/no-go and prioritization decisions.
• Lead and manage CRO collaborations ensuring scientific rigor data quality and timely delivery.
• Communicate scientific findings clearly and effectively in internal project teams and at external scientific meetings.

Qualifications:

• Ph.D. in pharmacology biochemistry biophysics or a related field with 2-year post-doctoral and/or industry research experience.
• Demonstrated depth in at least one of the following areas:
  • Receptor pharmacology preferably with class B GPCR targets
  • Metabolic disease biology including obesity and/or liver-related diseases
• Strong experience in designing executing and interpreting in vitro pharmacology assays or disease-relevant biological assays.
• Proven ability to take scientific ownership work independently and drive projects in a cross-functional environment.
• Excellent written and verbal communication skills.

Preferred

• Hands-on experience with receptor binding assays and/or binding kinetics methodologies (e.g. TR-FRET FP radioligand binding assays MST/SpS SPR sc-IC).
• Prior experience supporting GPCR-focused drug discovery programs.
• Experience managing CROs and external scientific collaborations.
• Prior experience in a fast-paced biotech or pharmaceutical R&D environment.

Travel Required:

Occasional domestic or international travel may be required for scientific conferences or business needs.

Structure Therapeutics Inc. is an Equal-Opportunity Employer.

Structure Therapeutics is committed to fair and equitable compensation practices and we strive to provide employees with total compensation packages that are market competitive. The exact base pay offered for this role will depend on various factors including but not limited to the candidates geography qualifications skills and experience.

At Structure base pay is only one part of your total compensation package. The successful candidate will be eligible for an annual performance incentive bonus new hire equity ongoing performance-based equity and various benefits offerings.

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Required Experience:

Staff IC