GSK is seeking a highly skilled and visionary Director Portfolio Decision Sciences to partner with the Head Portfolio Decision Sciences Oncology in supporting GSKs Oncology and broader Pharmaceutical portfolio across the entire R&D lifecycle from preclinical research through latestage clinical development.

In this influential role you will work directly with project teams and governance boards to evaluate investment opportunities in areas of high uncertainty and limited data. You will play a pivotal part in guiding technical progression and investment decisions through systematic risk assessment probabilistic evaluation and rigorous economic analysis (e.g. ROI NPV). Your insights will inform key decisionmaking bodies including the Portfolio Investment Board (PIB) Development Review Board (DRB) and Research Unit Investment Boards.

You will shape strategically differentiated options drive challenging conversations with senior leaders and leverage cuttingedge data and technology trends to enable highquality portfolio decision making.

The ideal candidate is an intellectually curious portfolio expert with deep R&D experience a passion for innovation and the ability to navigate and influence broadly across the Oncology and R&D ecosystems at GSK.

Key Responsibilities

In this role you will provide leadership across Decision Sciences and Portfolio Management for the Pharmaceutical portfolio including Oncology and nonOncology assets. You will support highimpact decisions at senior leadership levels ensuring objectivity crossportfolio consistency and strategic context. Specific responsibilities include:

• Guiding project teams across the R&D lifecycle (including BD opportunities) using strategic decision frameworks probabilityofsuccess elicitation and economic evaluations (ROI NPV) facilitating decision making and generating project and portfoliolevel insights.

• Delivering objective project assessments for R&D investment decisions at Research Unit governance bodies and the Portfolio Investment Board (PIB).

• Providing clear rigorous recommendations to governance chairs based on detailed valuerisk analyses option evaluations resource considerations and riskdischarge points.

• Leading portfolio or indicationlevel assessments to inform senior leaders on prioritisation decisions across scientific commercial operational strategic and financial dimensions.

• Supporting the biannual dynamic Portfolio Review (dPR) for Oncology ensuring refreshed project assessments and surfacing emerging investment opportunities.

• Collaborating across finance portfolio management strategy operations and Research Units to recommend short and longterm focus areas and enable optimal resource deployment.

• Driving portfolio management excellence by monitoring the external environment evaluating innovative portfolio approaches and proposing use cases applicable to GSK.

• Enhancing the development and deployment of advanced analytics including AI and machine learning to elevate decisionmaking quality across teams and senior leadership.

Basic Qualifications

We are looking for professionals with these required skills and experiences to achieve our goals:

• Bachelors degree in Science or Business.

• PhD MD or advanced scientific/decision sciences degree preferred .

• Demonstrated experience in pharmaceutical healthcare or related industries.

• Strong understanding of R&D processes ideally with experience supporting or leading drugdevelopment teams.

• Proven track record of independently delivering complex projects.

• Experience navigating crossfunctional teams and enabling change.

• High learning agility; ability to facilitate complex scientific technical value and resourcing discussions.

• Ability to translate detailed scientific and technical insights into concise impactful recommendations

• Strong relationshipbuilding skills to become a trusted strategic partner to project teams and senior leaders.

• Ability to manage multiple projects priorities and fastpaced decision cycles.

Closing Date for Applications 10 February 2026 (EOD)

Please take a copy of the Job Description as this will not be available post closure of the applying for this role please use the cover letter for your online application or your CV to describe how you meet the competencies for this role as outlined in the job requirements above. The information that you provide in your cover letter and CV will be used to assess your application.

Why GSK

Uniting science technology and talent to get ahead of disease together.

GSK is a global biopharma company with a purpose to unite science technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade as a successful growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory immunology and inflammation; oncology; HIV; and infectious diseases to impact health at scale.

People and patients around the world count on the medicines and vaccines we make so were committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients accountable for impact and doing the right thing is the foundation for how together we deliver for patients shareholders and our people.

GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race color religion sex (including pregnancy gender identity and sexual orientation) parental status national origin age disability genetic information (including family medical history) military service or any basis prohibited under federal state or local law.

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