Data Analyst RESEARCH NEUROLOGY kl

Site: The Brigham and Womens Hospital Inc.

Mass General Brigham relies on a wide range of professionals including doctors nurses business people tech experts researchers and systems analysts to advance our mission. As a not-for-profit we support patient care research teaching and community service striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham.

New budgeted research role

Job Summary

Summary

A computational data analyst position is available to support the Khurana Lab and Division of Movement Disorders at Brigham and Womans Hospital. We seek an applicant to i) perform analysis of high-throughput genomic and other omics data to enable novel discovery in Parkinsons disease and related degenerative movement disorders in collaboration with computer scientists in the laboratories of Shamil Sunyaev at Harvard Medical School and ii) manage multi-omic and clinical data collected through the Harvard Biomarker Study a longitudinal study of Parkinsons disease patients and healthy controls. We study the molecular basis of synucleinopathies such as Parkinsons multiple systems atrophy progressive supranuclear palsy etc with the goal of identifying novel therapeutic targets. We develop and utilize a range of multi-omic tools to analyze in vitro and in vivo experimental models as well as human genetic and single cell datasets. The Khurana Lab operates within a highly collaborative environment where both bench biologist and computer scientists work together with clinicians clinician-scientists and genetics this case the applicant will work closely with the multidisciplinary team to facilitate understanding the genetic basis of these diseases with the goal of developing precision medicines and gene-targeted therapies. Beyond genomic and omics analyses the candidate will work with genetic study coordinators to ensure secure storage update and maintenance of paired genetic and clinical data from HBS 2.0 and facilitate downstream discovery. Strong computational organizational and communication skills are desired for this position. More senior candidates will be considered for a Research Scientist or Senior Research Scientist positions with Research Associate appointments at Brigham and Womens Hospital and Harvard Medical School.

Does this position require Patient Care
No

Essential Functions
- Performs common/rare variant analyses including repeat and long-read sequencing analyses in collaboration with computer scientists in labs of Shamil Suyaev and Peter Park facilitating novel gene discovery.
-Manages HBS study database in collaboration with MassGeneral Brigham IT services and genetic study coordinators. This includes creating a relational database in SQL regularly updating the data tables by pulling data from third-party software platforms backing up the data at regular intervals performing quality control validation and error detection on each data point and ensuring data security and integrity.
-Runs standard omics analysis pipelines on datasets generated in-house as well by collaborators via in vitro and in vivo experimental models.
-Applies and adapts existing statistical and omics tools to achieve new biological insights from unique biological datasets.
-Works closely with bench scientists to understand and help accomplish their research goals.
-Writes and runs basic queries as needed.
-Assists in maintaining existing reporting systems.
-Contributes to presentations to key stakeholders.
-Works with senior analysts to design maintain and distribute reports.
-Learn leading practice analysis methodologies.
-Conducts continuous analysis of current performance and accurately forecast data trends.

Education

Bachelorsrequired. MSc or PhD in Computer Science Mathematics in a biological science or relevant field recommended.

Experience
Data Analysis Experience 0-1 year preferred

Knowledge Skills and Abilities

-Experiencewith existing bioinformatics tools or pipelines to perform standard next-generation sequencing (NGS) data analysis incl. genomic transcriptomic epigenomic and others.

-Developing or adapting new algorithms and pipelines to support customized data analysis.

-Strong computational genomics experience in at least two or more of the following NGS techniques: Single-cell and bulk tissue RNA-Seq spatial transcriptomics small RNA-Seq ATAC-SeqChIP-Seq whole-genome sequencing (WGS) whole-exome sequencing (WES) Hi-C etc.

-Experience in Programing withJavaScript Object Notation (JSON) R Pythonthatfocuson computational biological applications.

-Experience in SQL database creation and management writing stored procedures and queries for databases.

-Experience in writing programs using APIs to pull data from multiple third-partysoftwares.

-Experience in Shell scripting.

-Physical Server Administration.

-Security Compliance:HIPAA.

-Good organizational skills detail oriented.

-Experience with common bioinformatics and genomic browsers NCBIGenbank UCSC.

-Understanding the user of bioinformatics tools including common NGS tools BWAsamtools GATK.

-Ability to work in a highly collaborative and intellectually challenging environment.

-Ability todemonstrateprofessionalism.

-Ability todemonstratecritical thinking and creative problem-solving abilities.

-Ability to prepare manuscripts for presentation and publication.

-Must work independently.

-Excellent oral and written communication skills.

-Building proficiency in statistics data analysis and data sets.
-Proficient in time management and project management skills.
-Ability to exercise sound judgment to make decisions within the scope of job responsibilities.
-Demonstrated knowledge of and skill in word processing spreadsheet and database PC applications.
-Solid quantitative analytical and technical aptitude skills.
-Participate in dealing with all levels of employees /management and building proficient relationships with teams and all organizational customers.
-Able to find and define problems understand business impact identify solutions and provide recommendations for corrective action.

For applications please contact:

Dr. Daniel ElKodsi

Onsite

60 Fenwood Road

40

Regular

Day (United States of America)

Pay Range

$52000.00 - $74401.60/Annual

Grade

5

At Mass General Brigham we believe in recognizing and rewarding the unique value each team member brings to our organization. Our approach to determining base pay is comprehensive and any offer extended will take into account your skills relevant experience if applicable education certifications and other essential factors. The base pay information provided offers an estimate based on the minimum job qualifications; however it does not encompass all elements contributing to your total compensation addition to competitive base pay we offer comprehensive benefits career advancement opportunities differentials premiums and bonuses as applicable and recognition programs designed to celebrate your contributions and support your professional growth. We invite you to apply and our Talent Acquisition team will provide an overview of your potential compensation and benefits package.

2200 The Brigham and Womens Hospital Inc. is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race color religious creed national origin sex age gender identity disability sexual orientation military service genetic information and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process to perform essential job functions and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973 the Vietnam Veterans Readjustment Act of 1974 and Title I of the Americans with Disabilities Act of 1990 applicants who require accommodation in the job application process may contact Human Resources at .

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