Senior Scientist (III), Human Genetics Group
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Job Location:
North Chicago, IL - USA
Monthly Salary:
Not Disclosed
Posted on:
6 hours ago
Vacancies:
1 Vacancy
Job Summary
The Genomics Research Center within the Quantitative Medicine and Genomics organization at AbbVie is seeking a talented and motivated Senior Scientist to join the Human Genetics team to support our target discovery and development efforts. This individual will contribute to studies aimed at novel target discovery and understanding the biological mechanisms of diseases of interest to AbbVie. The ideal candidate will be detail-oriented and collaborate with cross-functional teams to design interpret and deliver genomic analyses that inform our pipeline. This position is in North Chicago IL with no remote option.
Key Responsibilities
- Lead genetics-driven target and biomarker identification across AbbVies therapeutic areas using cutting-edge methods and large-scale biobank datasets (e.g. FinnGen Alliance for Genomic Discovery UK Biobank All of Us) and clinical cohort data.
- Design and execute innovative approaches to uncover genotype-phenotype associations through disease-focused case-control and time-to-event study designs.
- Identify genetic determinants influencing disease progression and patient response to treatments.
- Analyze polygenic risk scores (PRS) to enhance patient stratification identify genetically defined subgroups gain insights into disease mechanisms and support precision medicine strategies.
- Assess heterogeneity in disease risk and investigate how PRS profiles are associated with differences in treatment responses.
- Systematically mine internal and external phenome-wide association study (PheWAS) datasets to identify novel and population-specific genetic associations.
- Analyze genomics data from clinical trial participants to identify response biomarkers and support reverse translation efforts.
- Perform and interpret post-GWAS analyses (e.g. fine mapping of GWAS loci GWAS signal colocalization with molecular QTLs Mendelian Randomization and others) to identify and prioritize causal genes and targets.
- Integrate single-cell omics and proteomics datasets with genomic and clinical data.
- Collaborate with therapeutic area scientists to generate therapeutic hypotheses support novel target identification and validation through exploratory analyses and facilitate progression through pipeline phase transitions.
- Lead cross-functional projects with therapeutic area leads.
Qualifications :
Required Qualifications
- Bachelors Degree or equivalent education and typically 10-12 years of experience Masters Degree or equivalent education and typically 8-10 years of experience PhD and 0-4 years of experience.
- Fluency in programming languages such as R and Python and working in command-line on HPC clusters.
- Expertise in biobank scale genome-wide association studies (GWAS) and rare variant association studies (RVAS).
- Hands-on experience in methods and tools such as PLINK SAIGE REGENIE fastGWA SKAT/ACAT.
- Hands-on experience working with different types of genotype data such as array WGS and imputed.
- Hands-on experience with electronic health records (EHR) and OMOP CDM format data.
- Familiarity with open-source genomics and omics resources (e.g. Open Targets HGMD GTEx eQTL Catalog and others).
Preferred Qualifications
- Previous industry experience in pharmaceutical or biotechnology companies working with large-scale human genetic datasets.
- Experience in cloud genomics research environments (e.g. All of Us Researcher Workbench UK Biobank Research Analysis Platform and FinnGen sandbox).
- Strong track record of relevant scientific publications and presentations.
Additional Information :
Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:
The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at thetime of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic locationand we may ultimately pay more or less than the posted range. This range may be modified in the future.
We offer a comprehensive package of benefits including paid time off (vacation holidays sick) medical/dental/vision insurance and 401(k) to eligible employees.
This job is eligible to participate in our short-term incentive programs.
Note: No amount of pay is considered to be wages or compensation until such amount is earned vested and determinable. The amount and availability of anybonus commission incentive benefits or any other form of compensation and benefits that are allocable to a particular employee remains in the Companys soleand absolute discretion unless and until paid and may be modified at the Companys sole and absolute discretion consistent with applicable law.
AbbVie is an equal opportunity employer and is committed to operating with integrity driving innovation transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.
US & Puerto Rico only - to learn more visit & Puerto Rico applicants seeking a reasonable accommodation click here to learn more:
No
Employment Type :
Full-time
Key Skills
- Laboratory Experience
- Mammalian Cell Culture
- Biochemistry
- Assays
- Protein Purification
- Research Experience
- Next Generation Sequencing
- Research & Development
- cGMP
- Cell Culture
- Molecular Biology
- Flow Cytometry
About Company
AbbVie is a global biopharmaceutical company focused on creating medicines and solutions that put impact first for patients, communities, and our world. We aim to address complex health issues and enhance people's lives through our core therapeutic areas: immunology, oncology, neuro ... View more
