Image Data Scientist in Center of Excellence for Structural Cell Biology

About the Role:

We are seeking a highly skilled and motivated Imaging Scientist to join our multidisciplinary team in developing and applying cutting-edge approaches for cryo-electron tomography and cryo-volume electron microscopy data analysis. The successful candidate will focus on image processing segmentation visualization and quantitative analysis of large 3D EM datasets to reveal (sub)cellular and molecular architecture underlying various biological processes. Working at the interface of cell biology computational imaging and data science this position offers a unique opportunity to contribute to discoveries that impact development of pediatric diseases.

The Worlds Brightest Minds Always Innovate

At St. Jude Childrens Research Hospital we know what can be achieved when the brightest scientific minds face the fewest barriers. Thats why we provide world-class facilities. State-of-the-art technologies. Extraordinary support. And a collaborative bench-to-bedside environment where you can see firsthand how your science translates into survival for the children we serve. Quite simply at St. Jude we encourage you to dream big and stop at nothing when it comes to finding cures and saving children.

Key Responsibilities:

• Develop and implement automated and semi-automated segmentation pipelines for volume EM datasets (FIB-SEM and TEM tomography).
• Apply and adapt machine learning and deep learning techniques for feature detection instance segmentation and 3D reconstruction.
• Perform quantitative image analysis including morphometric and spatial characterization of cellular and organellar structures.
• Manage large imaging datasets using high-performance computing and scalable data workflows.
• Document and disseminate computational methods contributing to open-source tools and scientific publications.
• Support training and mentorship of staff and collaborators in image analysis workflows.

Minimum Education and/or Training:

• Bachelors degree in applied mathematics physics chemistry bioinformatics computer science data science computer engineering or related field required.
• Masters degree preferred.

Minimum Experience:

• Minimum Requirement: Bachelors degree with 1 years of work experience in relevant area (e.g. applied mathematics physics chemistry bioinformatics computer science data science computer engineering) required.
• Experience Exception: Masters degree with no experience.
• Experience in image analyses image data management and programming (e.g. Python R Matlab Java C/C)
• Experience in image analysis platforms (e.g. ImageJ/Fiji CellProfiler) scientific computing scientific data visualization scientific computer code optimization and evaluation in an HPC environment development of algorithms statistical methods or scientific software working with large image data volumes biological/medical imaging.

Preferred Qualifications & Experience:

• PhD or equivalent degree in Structural Biology Biophysics Biochemistry Cell Biology or a related field
• Demonstrated expertise in 3D image processing and segmentation ideally with electron microscopy or other large-volume imaging modalities
• Experience with alignment of correlated light and electron microscopy datasets
• Experience with visualization tools such as Napari ChimeraX Blender or similar
• Experience with deep learning frameworks such as TensorFlow is a plus
• Familiarity with large-scale data management is advantageous
• Strong problem-solving skills
• Ability to work independently and within an interdisciplinary team
• Excellent communication skills and a collaborative mindset

The Worlds Best Stop at Nothing

Theres a reason St. Jude Childrens Research Hospital is consistently ranked on Glassdoors Best Places to Work list. Actually there are more than 5500 reasons. At our world-class pediatric research hospital every one of our 5500 professionals shares our commitment to making a difference in the lives of the children we serve. Theres a unique bond when you are part of a team that will stop at nothing to advance the treatments and cures of pediatric catastrophic diseases. The result is a collaborative positive environment where all employees regardless of their role receive the resources support and encouragement to advance and grow their careers.

Better at Work. Better at Life.

When you work at St. Jude youll join a highly collaborative work culture that inspires you every day to be your best. With opportunities for learning and growth you can shape a career path that is right for you while also enjoying all the benefits and stability of working for a world-class institution. This includes work-life balance with generous paid time-off and on-campus conveniences that make life a little easier. Join us and youll quickly see why St. Jude is consistently ranked by our employees on Glassdoor as a Best Place to Work.

Compensation

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