Director, Clinical Pharmacology & Quantitative Pharmacology (CPQP) Oncology

Introduction to role:
Are you ready to lead model-informed drug development that changes how cancer medicines are discovered and delivered As Director Clinical Pharmacology & Quantitative Pharmacology you will set clinical pharmacology strategy across a diverse oncology portfolio converting sophisticated quantitative insight into crucial program choices and regulatory confidence that accelerates impact for patients.

You will champion a culture of MIDD integrate advanced modeling with novel biomarkers and endpoints and develop early and late development plans that bring clarity faster. How would you bring to bear groundbreaking clinical pharmacology to sharpen benefitrisk understanding and drive go/no-go decisions with precision

Working across functions and with external partners you will evaluate licensing opportunities build drugdisease models that advise trial develop and dose selection and grow capabilities through mentoring and knowledge sharingcreating a scalable foundation for consistent highquality decision making.

Accountabilities:

• Model-Informed Drug Development Leadership: Build and embed a culture encouraging of MIDD in oncology; influence partners stakeholders and regulators on its value and application to elevate decision quality and speed.

• Portfolio Clinical Pharmacology Strategy: Plan and complete groundbreaking clinical pharmacology approaches with direct value across the portfolio enabling clear decision points and optimized development paths.

• End-to-End Development Input: Provide scientific and strategic feedback into pre-clinical clinical and post-approval plans to ensure coherent data-driven strategies that reduce uncertainty.

• Early and Late Development Oversight: Guide the supervision support and application of clinical pharmacology strategies in oncology through both early and late phases managing dose selection exposureresponse analysis and risk management.

• Licensing Evaluation: Support assessment of candidates for in- and out-licensing using quantitative evidence to assess opportunity risk and strategic fit.

• Quantitative Modeling: Contribute to drugdisease models and other modeling approaches to support internal and external decision making collaborating with internal teams and external partners when relevant.

• Discipline and Business Support: Partner with the Oncology and discipline lead on strategy scientific operations and business management to align priorities and resources.

• Peer Review and Mentorship: Provide peer review and mentoring within and across therapeutic areas strengthening scientific difficulty and consistency.

• Capability Building: Deliver training and knowledge sharing to advance the Clinical Pharmacology discipline and scale best practices.

• Methodology Horizon Scanning: Supervise internal and external environments for relevant new methodologies and applications to keep approaches current and competitive.

• External Scientific Profile: Increase AstraZenecas external profile in clinical pharmacology/MIDD through speaking engagements and publications in recognized journals to build industry thinking.

• Regulatory Alignment: Ensure clinical pharmacology strategies align with current regulatory expectations supporting successful submissions and interactions.

Essential Skills/Experience:

• Leadership in developing and embedding a culture supportive of MIDD in oncology with influence across partners stakeholders and regulators.

• Ability to plan and implement state-of-the-art clinical pharmacology approaches that drive portfolio value and enable go/no-go decision making.

• Evidence-based and forward-thinking input spanning pre-clinical clinical and post-approval development.

• Supervision guidance and delivery of oncology clinical pharmacology plans across early and late development.

• Experience supporting evaluation of candidates for in- and out-licensing.

• Contribution to drugdisease models alongside other modeling techniques for decision support in collaboration with internal and external partners.

• Support for discipline leadership in strategy scientific operations and business management.

• Proven peer review and mentoring across therapeutic areas.

• Dedication to providing education and sharing expertise to develop the Clinical Pharmacology field.

• ctive monitoring of emerging techniques and implementations relevant to clinical pharmacology and MIDD.

• Established external presence through speaking engagements and publications.

• Ensuring alignment of clinical pharmacology plans with current regulatory expectations.

Desirable Skills/Experience:

• Experience integrating quantitative pharmacology alongside innovative biological indicators AI-enabled analyses innovative endpoints and modern trial builds.

• Track record of leading cross-functional global teams to deliver sophisticated clinical pharmacology strategies at pace.

• Familiarity with emerging and non-traditional drug modalities and their clinical pharmacology considerations.

• Strong record of impactful publications and scientific presentations that influence practice or policy.

• Ability to translate sophisticated modeling outputs into clear actionable insights for diverse stakeholders including senior leaders and regulators.

• Experience collaborating with external consortia academic partners or industry groups to advance MIDD methodologies.

Why AstraZeneca:
Join a company where science is applied with urgency and imagination to transform cancer care. You will work with one of the most expansive oncology pipelines exploring nextgeneration modalities while combining advanced modeling with real-world data biomarkers and innovative trial designs. Expect unexpected teams in the same room unleashing ambitious thinking with unparalleled data and collaborative energy fueling decisive progress. We value kindness alongside ambition empowering you to take smart risks share learning openly and see your contributions translate into meaningful impact for patients.

Call to Action:
Step into this pivotal role to shape oncology decisions with quantitative clarity and bring smarter therapies to patientssubmit your application today!

Compensation Pay Range:

The annual base pay (or hourly rate of compensation) for this position is outlined above. Hourly and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors including market location job-related knowledge skills and addition our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles) to receive a retirement contribution (hourly roles) and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program401(k) plan; paid vacation and holidays; paid leaves; and health benefits including medical prescription drug dental and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired employee will be in an at-will position and the Company reserves the right to modify base salary (as well as any other discretionary payment or compensation program) at any time including for reasons related to individual performance Company or individual department/team performance and market factors.

Date Posted

Closing Date

Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and furtherance of that mission we welcome and consider applications from all qualified candidates regardless of their protected characteristics. If you have a disability or special need that requires accommodation please complete the corresponding section in the application form.