VP, Program Management

About Summit:

Summit Therapeutics Inc. is a biopharmaceutical oncology company with a mission focused on improving quality of life increasing potential duration of life and resolving serious unmet medical needs. At Summit we believe in building a team of world class professionals who are passionate about this mission and it is our people who drive this mission to reality. Summits core values include integrity passion for excellence purposeful urgency collaboration and our commitment to people. Our employees are truly the heart and soul of our culture and they are invaluable in shaping our journey toward excellence.

Summits team is inspired to touch and help change lives through Summits clinical studies in the field of oncology. Summit has multiple global Phase 3 clinical studies including:

Non-small Cell Lung Cancer (NSCLC)

• HARMONi: Phase 3 clinical study which was intended to evaluate ivonescimab combined with chemotherapy compared to placebo plus chemotherapy in patients with EGFR-mutated locally advanced or metastatic non-squamous NSCLC who were previously treated with a 3rd generation EGFR TKI.
• HARMONi-3: Phase 3 clinical study which is intended to evaluate ivonescimab combined with chemotherapy compared to pembrolizumab combined with chemotherapy in patients with first-line metastatic NSCLC.
• HARMONi-7: Phase 3 clinical study which is intended to evaluate ivonescimab monotherapy compared to pembrolizumab monotherapy in patients with first-line metastatic NSCLC.

Colorectal Cancer (CRC)

• HARMONi-GI3: Phase 3 clinical study intended to evaluate ivonescimab in combination with chemotherapy compared with bevacizumab plus chemotherapy.

Ivonescimab is an investigational therapy not presently approved by any regulatory authority other than Chinas National Medical Products Administration (NMPA). Summit is headquartered in Miami Florida and has additional offices in California New Jersey the UK and Ireland.

Overview of Role:

The Vice President Program Management reports to the Chief Business & Strategy Officer and will lead the cross-functional program management team to maximize the value of Summits pipeline drug candidates with a focus on SMT112 (ivonescimab) and drive execution of the development plans from multiple clinical trials (including Phase III trials) to BLA / MAA / other regulatory approval filings and commercialization. The Vice President of Program Management is accountable for establishing and maintaining an integrated project plan to cover all aspects of the SMT112 development program.

The Vice President of Program Management should stimulate creative and productive decision making motivate determine accountability and urgency identify opportunities and challenges and drive robust and informed discussions on risk identification and mitigation strategies. The Vice President of Program Management will lead with influence and have the negotiation and persuasion skills necessary to ensure success of the program and sets goals for the development of Summits lead asset SMT112 and specific program-related goals for the cross-functional team members

Role and Responsibilities:

• Establish and maintain the integrated SMT112 program plan through effective leadership and representation from cross-functional partners to create and execute a development plan that provides a thorough and clear strategy for maximizing the assets chances of development regulatory and commercial success.
• Integrating input from all functional areas to identify key development and commercialization issues and the strategic approach to resolve each issue including associated timelines and deliverables while also providing clarity on alternative pathways and the tradeoffs to be considered.
• Leading discussions with the cross-functional program team to reach decisions including overcoming challenges when full consensus cannot be reached.
• Documenting all key decisions and creating a documentation that is appropriate for the Executive Committee as well as detailed granular plans to support higher-level timelines and tasks.
• Reporting and presenting program information to the Executive Committee functional heads and other key stakeholders.
• Driving decision-making for development of the pipeline candidates focused on SMT112 leading to its marketing approval and subsequently its lifecycle strategy ensuring relevant research analysis competitive data and expertise are taken into account.
• Challenging cross-functional representatives to ensure that all issues and questions are being addressed and that functional area input into the strategy is adequate to meet the objectives of the molecule.
• Managing the complexity of internal / external development and proactively identifying issues and risks while leading contingency planning and problem solving.
• Ensuring development and implementation of optimal clinical regulatory and medical affairs strategies to protect and maximize asset value.
• Ensuring adequate project resource utilization and budget management providing clarity and transparency on changes and potential tradeoffs.
• Mentoring coaching and developing the team members.
• Ensuring team alignment with the Executive Committee and executing on feedback with regard to Go / No-Go decisions timelines key activities resource allocations and budgets valuations and prioritization.
• Driving strategic alignment for development research regulatory and medical affairs.
• Maintaining a focus on pipeline value rather than single project value and a commitment to maximizing portfolio value by supporting Go decisions and appropriately arriving at No-Go decisions.
• Other duties as assigned

Experience Education and Specialized Knowledge and Skills:

• Experience with drug development in oncology is required.
• Bachelors degree required; advanced degree (MBA MS PhD PharmD) strongly preferred.
• 12 years of experience in program management or similar function within biopharmaceutical or life sciences organizations required.
• Experience in late-stage drug development and registration preferred.
• Experience in cross-functional team leadership including strategy development and driving tactical delivery of programs.
• Prior experience in pre-commercial or early commercial biotech/pharma strongly preferred.
• Proven ability to translate complex data into executive-ready insights.
• Expertise in project management and process improvement methodologies (PMP Lean Six Sigma Agile).
• Strong analytical mindset
• Change leadership in fast-paced evolving environments
• Cross-functional collaboration and influence

The pay range for this role is $285000-$330000 annually. Actual compensation packages are based on several factors that are unique to each candidate including but not limited to skill set depth of experience certifications and specific work location. This may be different in other locations due to differences in the cost of labor. The total compensation package for this position may also include bonus stock benefits and/or other applicable variable compensation.

Summit does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact Summits Talent Acquisition team at to obtain prior written authorization before referring any candidates to Summit.