Senior Scientist, Antibody Discovery & Engineering
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Job Location:
Bothell, WA - USA
Monthly Salary:
$ 90900 - 151500
Posted on:
5 days ago
Vacancies:
1 Vacancy
Job Summary
Senior Scientist Antibody Discovery & Engineering
Job Description
ROLE SUMMARY:
As a research scientist you will be part of Pfizers Worldwide Research and Development team that employs a multidisciplinary approach to identify cancer targets and develop next generation Oncology therapeutics and therapeutic this role you will contribute to the development of novel biotherapeutics as a molecular biology subject matter expert. You will be responsible for extensive molecular biology design experimentation and analysis including construct design vector cloning and NGS library preparation. You will also contribute to molecular analyses of cancer targets cell line engineering antibody sequencing identification of sequence liabilities and antibody engineering.
With your deep knowledge in the discipline you will be an active team member who influences at the project team level. You will be using your scientific judgment to adapt standard methods and techniques by applying prior work experience and consulting others. Your ability to plan will help in preparing short-term work activities on projects. Your creativity in developing novel processes and new ideas will be used frequently. You will undertake mentoring activities to guide your team members. It is your innovative scientific temperament that will help in making Pfizer ready to achieve new milestones and help patients across the globe.
ADDITIONAL POINTS:
Provide molecular biology and engineering support for multiple Oncology Research projects
Generate analyze and engineer antibody sequences to deliver an optimized therapeutic lead
Contribute to achievement of goals and influence at the project team level
Evaluate data and provide clear reports that can be shared and transferred to and from cross-functional teams
Pay attention to detail strictly adhere to safety protocols and use knowledge of basic laboratory procedures to advance projects under rapidly shifting priorities and timelines
BASIC QUALIFICATIONS:
Ph.D. in Molecular Biology or related discipline or Bachelors degree 9 years research experience or Masters degree 7 years research experience
Experience working with antibody sequences including diversity analysis liability identification and CDR annotation
Molecular biology skills including RNA/DNA extractions primer design PCR plasmid cloning and NGS library prep
Familiarity with sequence analysis software such as Snapgene and/or Geneious Prime
Understanding of protein structure and biology; working knowledge of online bioinformatics tools to analyze gene mRNA and protein sequences.
Demonstrated ability to work independently and collaboratively adapting to project needs
Ability to organize and prioritize work to meet timelines and deliverables
Strong written and verbal communication skills including ability to accurately document experiment data and present results
PREFERRED QUALIFICATIONS:
Proficiency in Oxford Nanopore sequencing and data analysis
Experience coding in Python R or other programming language
Understanding of antibody biology and antibody drug conjugates (ADCs)
Experience with cell engineering technologies such as transfection nucleofection lentiviral transduction and CRISPR
Proficiency in culturing multiple cell lines under BSL2 conditions
Exposure to working in the biopharmaceutical industry
Passion for identifying and implementing new technologies that improve workflow efficiency and deliverable quality
PHYSICAL/MENTAL REQUIREMENTS
Lifting sitting standing walking bending ability to perform mathematical calculations and ability to perform complex data analysis
Must be able to wear specialized protective clothing and PPE (lab coat safety shoes/glasses/etc)
Additional Information:
- Work Location Assignment:On Premise
- Relocation Support Available
Relocation assistance may be available based on business needs and/or eligibility.
Sunshine Act
Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care providers name address and the type of payments or other value received generally for public disclosure. Subject to further legal review and statutory or regulatory clarification which Pfizer intends to pursue reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse your name address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter please do not hesitate to contact your Talent Acquisition representative.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race color religion sex sexual orientation age gender identity or gender expression national origin disability or veteran status. Pfizer also complies with all applicable national state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
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Required Experience:
Senior IC
Key Skills
- Laboratory Experience
- Mammalian Cell Culture
- Biochemistry
- Assays
- Protein Purification
- Research Experience
- Next Generation Sequencing
- Research & Development
- cGMP
- Cell Culture
- Molecular Biology
- Flow Cytometry
About Company
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