Research Assistant Associate, Structural Biology [LKCMedicine]
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Posted on:
Yesterday
Vacancies:
1 Vacancy
Job Summary
The Lee Kong Chian School of Medicine (LKCMedicine) trains doctors who put patients at the centre of their exemplary care. The School which offers both undergraduate and graduate programmes is named after local philanthropist Tan Sri Dato Lee Kong Chian. Established in 2010 by Nanyang Technological University Singapore in partnership with Imperial College London LKCMedicine aims to be a model for innovative medical education and a centre for transformative research. The Schools primary clinical partner is the National Healthcare Group a leader in public healthcare recognised for the quality of its medical expertise facilities and teaching. The School is transitioning to an NTU medical school ahead of the 2028 successful conclusion of the NTU-Imperial partnership to set up a Joint Medical August 2024 we welcomed our first intake of the NTU MBBS programme that has been recently enhanced to include themes like precision medicine and Artificial Intelligence (AI) in healthcare with an expanded scope in the medical humanities. Graduates from the five-year undergraduate medical degree programme will have a strong understanding of the scientific basis of medicine with an emphasis on technology data science and the humanities.
Dr. Chuchu Wangs lab is an interdisciplinary research lab integrating cryo-EM/ET lipidomics and NMR to study proteinlipid interactions in the brain. The key objective is to support efforts to identify how these interactions contribute to neurological disorders and to discover potential therapeutic targets.
We are looking for aResearch Assistant/Associate to explore the molecular and structural mechanisms underlying protein phase separation. The role will focus on investigating the structural basis of condensate formation and the assembly of synaptic protein complexes at near-atomic resolution by cutting-edge technologies cryo-electron microscopy and tomography (cryoEM/ET) and other biochemical and biophysical approaches. This role of person will have the opportunity to work at the interface of neuroscience structural biology advancing our understanding of how synaptic proteins and lipids form liquid-like condensates that regulate neurotransmitter release and synaptic organization providing possible new strategies or therapies to neurodegenerative diseases.For more details please view Responsibilities:
Isolation and purification of synaptic vesicles and proteins from mouse models and .
Sample preparation for Cryo-EM and other biophysical assays
Data collection and image processing of Cryo-EM datasets
Biochemical characterization of phase separation
Collaboration with team members to interpret structural and functional data
Required educational qualification experience skills and competencies:
Bachelors (for Research Assistant) or Masters (for Research Associate) degree in the field of Biological Sciences preferred Biochemistry Structural Biology Biophysics Neuroscience or a related field
Hands-on experience in protein expression purification and cryoEM sample preparation
Familiar with microscopy techniques or structural data analysis
Good written and oral communication skills
Strong motivation to learn new techniques
Good analytical and communication skills with the ability to work well in a team and independently
Required Experience:
IC
Key Skills
- Laboratory Experience
- ELISA
- Immunoassays
- Mammalian Cell Culture
- Biochemistry
- Cell Biology
- Research Experience
- Cell Culture
- Molecular Biology
- Microscopy
- Research Laboratory Experience
- Western Blot
About Company
Nanyang Technological University is one of the top universities in Singapore offering undergraduate and postgraduate education in engineering, business, science, humanities, arts, social sciences, education and medicine.
