Associate Scientist (Pooled Lentiviral Base Editing Screening)
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Job Location:
Memphis, TN - USA
Yearly Salary:
$ 65520 - 114400
Posted on:
2 days ago
Vacancies:
1 Vacancy
Job Summary
The Worlds Brightest Minds Always Innovate
At St. Jude Childrens Research Hospital we know what can be achieved when the brightest scientific minds face the fewest barriers. Thats why we provide world-class facilities. State-of-the-art technologies. Extraordinary support. And a collaborative bench-to-bedside environment where you can see firsthand how your science translates into survival for the children we serve. Quite simply at St. Jude we encourage you to dream big and stop at nothing when it comes to finding cures and saving children.
Key Responsibilities:
- Design optimize and execute pooled lentiviral screening workflows for large-scale peptide inhibitor characterization
- Collaborate closely with bioinformaticians and project investigators to ensure robust experimental design data acquisition and analysis.
- Support the development of innovative experimental strategies to expand and enhance existing screening capabilities.
- Contribute to collaborative research outputs including publications and conference presentations.
Ideal Candidate:
- PhD (or equivalent experience) in Molecular Biology Cell Biology Genetics or a closely related field.
- Demonstrated expertise in the design production and application of lentiviral vectors for genetic manipulation and screening.
- Proven track record in developing implementing or applying high-throughput genetic perturbation or functional screening approaches.
- Excellent organisational communication and record-keeping skills.
- Strong problem-solving ability and capacity to work independently as well as collaboratively.
Desirable Attributes:
- Extensive expertise in the design production and application of lentiviral libraries for large-scale screening.
- Familiarity with large-scale data generation and interpretation in screening contexts.
- Proven expertise in the design and execution of assays to characterise proteinprotein interactions.
- Evidence of contributions to collaborative research initiatives or consortia.
About the Research Environment:
The Davey lab has recently joined the Department of Cell and Molecular Biology to launch a research program applying high-throughput screening approaches to uncover the therapeutic potential of intrinsically disordered regions. The post-holder will work within a collaborative supportive team and benefit from world-class core facilities and excellent opportunities for professional development.
What problem are we tacklingTarget discovery is a critical foundation of drug development underpinning efforts to overcome the persistent challenges of drug resistance emerging pathogens and complex diseases that lack effective therapies. By uncovering novel proteins and molecular pathways driving disease progression we can enable the rational design of more selective interventions that reduce off-target effects and improve patient outcomes. The development of tool molecules coupled with detailed characterization of their inhibitory mechanisms provides a direct bridge between phenotypic observations and small-molecule drug design accelerating the translation of basic discoveries into clinically actionable therapies.
What is our approachShort Linear Motifs (SLiMs) are compact functional modules embedded within the intrinsically disordered regions of proteins. They mediate a wide range of regulatory processes including the assembly of dynamic complexes recruitment of modifying enzymes control of protein stability and specification of subcellular localisation. Despite their central role in cellular regulation SLiM-binding pockets remain a largely untapped class of therapeutic targets. By applying large scale base-editing and peptide inhibitor studies the project will address three key questions: (i) How essential are SLiM-mediated interactions for cellular fitness (ii) Does SLiM essentiality differ between healthy and diseased cells (iii) Can these interactions be selectively targeted for therapeutic intervention
Minimum Education and/or Training:
- Bachelors degree in a relevant scientific area
Minimum Experience:
- 7 years of research experience is required with a Bachelors degree.
- 5 years of research experience is required with a Masters degree.
- 2 years of research experience is required with a PhD.
Better at Work. Better at Life.
When you work at St. Jude youll join a highly collaborative work culture that inspires you every day to be your best. With opportunities for learning and growth you can shape a career path that is right for you while also enjoying all the benefits and stability of working for a world-class institution. This includes work-life balance with generous paid time-off and on-campus conveniences that make life a little easier. Join us and youll quickly see why St. Jude is consistently ranked by our employees on Glassdoor as a Best Place to Work.
Benefits
Your health and well-being are important to us. Thats why St. Jude Childrens Research Hospital provides employees with high-quality benefits choices.
We are committed to ensuring our benefits are competitive and affordable. St. Jude continues to cover medical premiums for employees and offers low additional costs for dependents.
Have More in Memphis
Get the best of big-city amenities mixed with all the charm of a small-town feel when you live in Memphis. From our world-renowned music scene to our eclectic mix of food and people. Memphis is a place our employees are proud to call home. Our region enjoys a cost of living more than 20% lower than the national average and our state places no personal income tax on wages. Plus Memphians spend five hours less per year in their daily commute compared to the national average. Learn how you can Have More in Memphis.
Compensation
In recognition of certain U.S. state and municipal pay transparency laws St. Jude is including a reasonable estimate of the compensation range for this role. This is an estimate offered in good faith and a specific salary offer takes into account factors that are considered in making compensation decisions including but not limited to skill sets experience and training licensure and certifications and other business and organizational needs. It is not typical for an individual to be hired at or near the top of the salary range and compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current salary range is $65520 - $114400 per year for the role of Associate Scientist (Pooled Lentiviral Base Editing Screening).Explore our exceptional benefits!
No Search Firms
St. Jude Childrens Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.
Required Experience:
IC
Key Skills
- Laboratory Experience
- ELISA
- Immunoassays
- Transfection
- Mammalian Cell Culture
- Suspension Experience
- Biochemistry
- Assays
- cGMP
- Cell Culture
- Molecular Biology
- Flow Cytometry
About Company
A leading children’s hospital, St. Jude treats the toughest childhood cancers and pediatric diseases. Learn about patient referrals, and donate so families never receive a bill for treatment, travel, housing or food.
