Scientist, Developmental Biology

Dallas, IA - USA

Monthly Salary: Not Disclosed

Posted on: 3 days ago

Vacancies: 1 Vacancy

Job Summary

The Developmental Biologist works within mammalian species teams to design and conduct experiments that will inform genetic engineering for de-extinction projects. Leveraging their expertise in genetics and developmental biology they will work closely with bioinformaticians to identify phenotype-relevant genetic pathways and variants and test the effect of those variants in embryonic organoid and cellular models.

**This position is based on-site in Dallas TX. Relocation assistance is available**

Duties and Responsibilities:

Maintain expertise and familiarity with genetics and development literature
Microdissect defined substructures from stem cell niches that give rise to mineralized and cornified hard-tissue and soft-tissue epithelial-mesenchymal appendages
Stage sample and manipulate fetal and embryonic tissues and structures
Design develop and implement novel experiments techniques procedures protocols and systems in line with research program objectives for non-model animals
Build RNase-safe low-input workflows from collection through library QC for multiomic data including bulk single-cell and spatial gene expression and chromatin conformation state and accessibility assays
Work closely with the bioinformatics team to identify genetic variants of interest
Process image and analyze fetuses of various stages using techniques such as fluorescent microscopy whole mount skeletal staining and morphometrics
Contribute to and be responsible for documentation reports presentations and publications associated with work

Skills and Abilities:

Hands-on wet lab experience with mammalian fetal development sampling and manipulation such as electroporation or embryonic tissue transplantation OR relevant experience in other fetal system
Strong working knowledge of gene regulatory networks in fetal development
Demonstrated success in preparing DNA and RNA from low-input or challenging tissues for multiomic assays (e.g. scRNA-seq scATAC-seq CUT&RUN/CUT&Tag/ChIP-seq)
Strong working knowledge of research methodology and study design; hypothesis testing; qualitative and quantitative data interpretation and application
Exceptional verbal and written communication skills
Demonstrated ability to take the initiative to move projects forward make independent judgments maintain accurate lab data clearly understand and respond to experimental results while communicating effectively
Ability to work independently and collaboratively as required in a fast-paced matrixed team environment consisting of internal and external team members
Analytical and creative thinker with excellent problem-solving skills and the ability to prioritize own work and adapt to changing team priorities
Excellent planning organization and time management skills
Very high level of comfort with productivity and communication software platforms (MS Office GSuite Slack digital notebooks project management systems etc.)

Qualifications:

DVM/PHD in developmental biology biological sciences veterinary medicine bioengineering molecular biology genetics or any science related field is required
2 years of wet lab research experience in developmental biology strongly preferred
2 years of experience working with bioinformaticians or computational biologists on generating multiomic data sets strongly preferred

What Colossal Offers You:

Medical dental and vision coverage
Unlimited PTO and company holidays so you can rest and recharge
Flexible spending accounts (FSA)
Company matched 401k retirement plan
Paid parental leave up to 12 weeks
Education reimbursement
An opportunity to help us return the Earth to a healthier state

The team at Colossal is committed colorful passionate intelligent collaborative creative experienced scientific and world-class. That sounds like a lot to fit into one building. Thats why we are spread out in several locations that include laboratories test facilities academic institutions libraries and offices.

Through it all however we maintain a culture of positivity hope happiness and belief that were doing something big. Something Colossal.

Colossal is proud to be an equal employment opportunity workplace. We welcome people from all backgrounds as well as celebrate and support diversity. We are committed to providing an inclusive environment of mutual respect that is free from discrimination and harassment so everyone can thrive.

EEO is the Law

Search Firm Representatives: Colossal does not accept unsolicited assistance from search firms. No fees will be paid for a hired candidate where no pre-existing agreement is in place. We handle most recruitment in-house.

Colossal is proud to be named a Best Place to Work by BuiltIn for 3 years in a row across multiple categories inand 2025:

#1 on the 50 Best Startups to Work For in Dallas in 2023!
100 Best Midsize Places to Work in Dallas in 2024 & 2025
100 Best Places to Work in Dallas TX (All Size Employers) in 2024 & 2025

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Most Loved Workplace Certification Page - Proud to be certified as a most loved workplace including: most loved CEO most loved workplaces for LGBTQ most loved workplaces for women and most loved workplaces for young professionals.

Newsweeks Most Loved Workplaces 2024 Award List - Excited to be amongst the winners of Newsweeks 2024 Most Loved Workplaces!

**This position is based on-site in Dallas TX. Relocation assistance is available**

Duties and Responsibilities:

Maintain expertise and familiarity with genetics and development literature
Microdissect defined substructures from stem cell niches that give rise to mineralized and cornified hard-tissue and soft-tissue epithelial-mesenchymal appendages
Stage sample and manipulate fetal and embryonic tissues and structures
Design develop and implement novel experiments techniques procedures protocols and systems in line with research program objectives for non-model animals
Build RNase-safe low-input workflows from collection through library QC for multiomic data including bulk single-cell and spatial gene expression and chromatin conformation state and accessibility assays
Work closely with the bioinformatics team to identify genetic variants of interest
Process image and analyze fetuses of various stages using techniques such as fluorescent microscopy whole mount skeletal staining and morphometrics
Contribute to and be responsible for documentation reports presentations and publications associated with work

Skills and Abilities:

Hands-on wet lab experience with mammalian fetal development sampling and manipulation such as electroporation or embryonic tissue transplantation OR relevant experience in other fetal system
Strong working knowledge of gene regulatory networks in fetal development
Demonstrated success in preparing DNA and RNA from low-input or challenging tissues for multiomic assays (e.g. scRNA-seq scATAC-seq CUT&RUN/CUT&Tag/ChIP-seq)
Strong working knowledge of research methodology and study design; hypothesis testing; qualitative and quantitative data interpretation and application
Exceptional verbal and written communication skills
Demonstrated ability to take the initiative to move projects forward make independent judgments maintain accurate lab data clearly understand and respond to experimental results while communicating effectively
Ability to work independently and collaboratively as required in a fast-paced matrixed team environment consisting of internal and external team members
Analytical and creative thinker with excellent problem-solving skills and the ability to prioritize own work and adapt to changing team priorities
Excellent planning organization and time management skills
Very high level of comfort with productivity and communication software platforms (MS Office GSuite Slack digital notebooks project management systems etc.)

Qualifications:

DVM/PHD in developmental biology biological sciences veterinary medicine bioengineering molecular biology genetics or any science related field is required
2 years of wet lab research experience in developmental biology strongly preferred
2 years of experience working with bioinformaticians or computational biologists on generating multiomic data sets strongly preferred

What Colossal Offers You: