Postdoctoral Fellow-MSH

New York City, NY - USA

Monthly Salary: Not Disclosed

Posted on: 12 hours ago

Vacancies: 1 Vacancy

Job Summary

Description

Pathology and Cell Based Medicine (primary) / Neuroscience (secondary)

Physical work location:

Icahn School of Medicine at Mount Sinai

1425 Madison Avenue

Icahn 9-02C

New York City NY 10029

Name PI or Supervisor: Nadia (Nadejda) Tsankova -

Web link to Lab: postdoctoral fellow with interest and expertise in neuro-oncology molecular neurobiology multi-omics and cancer epigenetics to work on high-impact projects in the field of glioma biology surrounded by the intellectually stimulating cancer environment at Mount Sinai in NYC.

The labs main research question is to understand how brain tumor (glioma) cells co-opt normal neurodevelopmental molecular programs to maintain their malignant cancer stem cell-like phenotype focusing on the role of epigenetics and transcriptional regulation. We employ cutting edge computational multi-omics tools combined with cell culture and animal studies using patient-derived glioma models. Currently R01-funded research spans mechanistic (functional genomic and computational) to translational (preclinical drug efficacy) studies with a focus on the role of Hippo signaling in glioma invasion and progression.

Technical Duties: (include any protocols)

In vitro cell culture experience preferably in the field of neuroscience and/or cancer biology

Molecular biology experience (DNA/RNA/Protein-based assays; Epigenetic assays; Cloning; knockdown/knockout using siRNA/lentivirus; etc)

Live cell imaging Confocal microscopy Histology

In vivo animal care orthotopic surgery drug delivery (optional)

Bioinformatics coding in R processing and analysis of NGS data (optional)

Qualifications

PhD required

Experience Required:

Strong background in either pure experimental neurobiology (cell culture and animal modeling) or in computational biology and bioinformatics with some experimental biology skills preferably in the field of cancer biology or neurobiology.

Strong motivation and dedication towards independent scientific career in academia

Strong work ethic ability to multitask and work in a collaborative team setting

For applicants with computational background at least some experience in sample processing and analysis of bulk and single cell next generation sequencing data is required including familiarity with UNIX submitting jobs on a computing cluster and programming experience in python R (or equivalent).

Goals/Outcomes of the Research Project:

The ultimate goal of this project is to uncover better strategies for reversing malignant tumor growth and migratory spread in glioblastoma.

DescriptionPathology and Cell Based Medicine (primary) / Neuroscience (secondary)Physical work location: Icahn School of Medicine at Mount Sinai 1425 Madison Avenue Icahn 9-02C New York City NY 10029Name PI or Supervisor: Nadia ...