Principal Scientist, High-Throughput Sequencing
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Job Location:
Morrisville, NC - USA
Monthly Salary:
Not Disclosed
Posted on:
30+ days ago
Vacancies:
1 Vacancy
Job Summary
SAGA Diagnostics is a personalized cancer diagnostics and disease monitoring company focused on molecular genetic analysis of circulating tumor DNA (ctDNA). The companys mission is to improve precision cancer medicine provide more accurate treatment monitoring and improve patient survival using minimally-invasive liquid biopsy cancer testing services. SAGAs proprietary tests can help patients oncologists and drug developers detect actionable mutations stratify patient groups and monitor treatment response residual disease and disease recurrence at unprecedented sensitivity and scale.
We are seeking a Principal Scientist High-Throughput Sequencing to lead the design development and optimization of next-generation sequencing (NGS)-based assays for molecular residual disease testing (MRD). The ideal candidate is an innovative scientist with deep expertise in sequencing technologies assay development and data-driven decision-making who thrives at the interface of research engineering and clinical translation. This individual will serve as a technical leader mentor and strategic contributor within our growing R&D organization.
Key Responsibilities
- Lead the development and optimization of high-throughput sequencing assays with a focus on sensitivity specificity and scalability for clinical deployment.
- Evaluate and implement emerging sequencing technologies (short-read long-read single-cell or spatial omics) to enhance assay performance.
- Collaborate cross-functionally with bioinformatics automation engineering and clinical development teams to design robust end-to-end workflows.
- Design and oversee analytical validation studies including assay reproducibility limit of detection and dynamic range.
- Drive innovation strategy in sequencing staying abreast of new chemistries platforms and library preparation methods relevant to diagnostics.
- Mentor junior scientists and research associates fostering technical excellence and career growth.
- Author scientific publications presentations and contribute to regulatory submissions (CLIA/CAP/FDA).
Requirements
- Ph.D. in Molecular Biology Genomics Biochemistry Bioengineering or a related field.
- 8 years of experience in high-throughput sequencing assay development (academic biotech or diagnostics).
- Demonstrated expertise in NGS library prep target enrichment barcoding/multiplexing and sample QC.
- Strong track record of assay development and technology transfer into clinical or commercial labs.
- Experience analytically validating NGS assays including writing validation plans and reports
- Familiarity with bioinformatics pipelines and statistical principles for NGS assay validation.
- Excellent communication skills with a proven ability to lead cross-functional teams and mentor scientists.
Benefits
Competitive Compensation and company wide benefits plan
Opportunities for career advancement and professional development.
A collaborative and innovative work environment dedicated to improving oncology outcomes.
SAGA Diagnostics is an equal opportunity employer fully committed to achieving a diverse and inclusive workplace that embraces and encourages applicants of every background. The companys policy regarding equal employment opportunity means that all decisions regarding recruitment hiring benefits wage and salary administration scheduling disciplinary action and termination will be made without unlawful discrimination on the basis of sex gender race color age national origin religion disability medical condition genetic information marital status sexual orientation gender identity or expression citizenship status pregnancy or maternity veteran status or any other status protected by applicable federal state or local law. If you require reasonable accommodation in completing an application interviewing or otherwise participating in the employee selection process please direct your inquiries to SAGA Diagnostics is a participant in the E-Verify program learn more about the program and review our required disclosureshereandhere.
Required Experience:
Staff IC
Key Skills
- Machine Learning
- Python
- Data Science
- AI
- R
- Research Experience
- Sensors
- Drug Discovery
- Research & Development
- Natural Language Processing
- Data Analysis Skills
- Toxicology Experience
About Company
SAGA Diagnostics is a personalized cancer medicine and disease monitoring company focused on molecular genetic analyses of circulating tumor DNA and tissue biopsies.
