Senior Scientist, Radioconjugate

WHY JOIN US

At AstraZeneca we are dedicated to being a Great Place to Work where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. With an ambitious goal of delivering 20 new medicines by 2030 there is no better place to make a difference in medicine for patients and in society.

Join us on this exciting journey to pioneer the future of healthcare. Our inclusive culture champions diversity and collaboration and we are always committed to lifelong learning growth and development. As part of our team youll contribute to groundbreaking advancements that will shape a healthier future for people everywhere. Be a catalyst for change at AstraZeneca where your work will have a real impact on improving peoples lives.

This is a 100% on-site role based in our lab in Hamilton Ontario.

About the Opportunity

Are you ready to make a significant impact in the field of cancer research We are looking for a dynamic and independent Senior Scientist with a passion for radiopharmaceutical development to join our radioconjugate portfolio team in Hamilton Ontario Canada. This role requires a proven track record of scientific excellence and project leadership experience.

As a Senior Scientist you will be the tumor biology technical lead for emerging radioconjugate programs collaborating with internal teams and external partners to advance novel targeted alpha therapies. This laboratory-based position involves study design hands-on execution data analysis interpretation and cross-functional communication. You will lead preclinical pharmacology studies and support in vivo evaluations generating decision-ready data packages to drive preclinical development forward.

Accountabilities

• Serve as an independent technical lead for radioconjugate programs collaborating with cross-functional teams and external partners to generate critical program data for project milestone decisions.

• Stay up-to-date with technical intellectual and scientific expertise in tumor biology and cancer modeling particularly related to targeted radioconjugates.

• Lead preclinical pharmacology studies including radioligand binding internalization and retention assays.

• Support in vivo biodistribution imaging and efficacy evaluations.

• Plan and conduct in vitro studies and support in vivo studies to generate decision-ready data packages.

• Analyze and present results to core project teams prepare materials for governance interactions and deliver program updates across internal forums.

Essentials Skills and Experience

• PhD Degree with 3 years of experience Masters Degree with 5 years of experience or a Bachelors Degree with 7 years and project leadership experience in a relevant discipline related to tumor and radiation biology

• Demonstrates a strong knowledge of cancer/cell biology radiation biology and/or biochemistry in the context of cancer with a robust desire for continued learning

• Expertise in routine cell culture particularly culture of tumor cells

• Expertise in molecular- and cell-based methodologies such as cloning/gene editing cytotoxicity assays binding and internalization assays flow cytometry ELISA and Western blotting

• Works independently with minimal supervision to conduct experiments analyze data and prepare results for internal and external presentations and regulatory filings

• Excellent communication presentation and interpersonal skills evidenced by a history of successful project delivery in team-oriented collaborative environments

• A proven track record of productivity as demonstrated by scientific publications in high quality peer-reviewed journals

• Ensures own work and work of peers is compliant with Good Laboratory Practice Safety Health and Environment standards and all other relevant internal AstraZeneca standards and external regulations

Desirable Skills and Experience

• Demonstrated proficiency in targeted radiopharmaceutical therapies and/or imaging and a broad up-to-date understanding of the field is highly preferred

• Prior experience in the biopharmaceutical industry and familiarity managing data delivery through contract research organizations preferred

• Demonstrated ability to coordinate project activities and provide scientific mentorship to junior scientists is highly preferred

• Direct hands-on experience in residualization & saturation binding assays radioimaging (PET or SPECT) biodistribution studies non-clinical dosimetry and other pre-clinical radiopharmaceutical methods is highly desirable

• Experience with targeted alpha emitter therapeutics is an asset

SO WHATS NEXT

To be considered for this exciting opportunity please complete the full application on our website at your earliest convenience it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity. If you know someone who would be a great fit please share this posting with them.

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• Top 100 Employers Award
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Are you interested in working at AZ apply today!

AstraZeneca is an equal opportunity employer that is committed to diversity and inclusion and providing a workplace that is free from discrimination. AstraZeneca is committed to accommodating persons with disabilities. Such accommodation is available on request in respect of all aspects of the recruitment assessment and selection process and may be requested by emailing.

Date Posted

Closing Date

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds with as wide a range of perspectives as possible and harnessing industry-leading skills. We believe that the more inclusive we are the better our work will be. We welcome and consider applications to join our team from all qualified candidates regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment) as well as work authorization and employment eligibility verification requirements.