Sr Scientist, Non clinical Bioanalysis

Work Schedule

Environmental Conditions

Job Description

Job Description

Role: Sr Scientist non clinical Bioanalysis

This is a fully onsite role based at our customers site in Cambridge MA. We welcome applicants from all locations within the US. Please note that relocation assistance is not provided for this position and any relocation costs will be the responsibility of the candidate.
Must be legally authorized to work in the United States withoutsponsorship.
Must be able to pass a comprehensive background check whichincludes a drug screening.

At Thermo Fisher Scientific youll discover meaningful work that makes a positive impact on a global scale. Join our colleagues in bringing our Mission to life - enabling our customers to make the world healthier cleaner and safer. We provide our teams with the resources needed to achieve individual career goals while taking science a step beyond through research development and delivery of life-changing therapies. With clinical trials conducted in 100 countries and ongoing development of novel frameworks for clinical research through our PPD clinical research portfolio our work spans laboratory digital and decentralized clinical trial services. Your determination to deliver quality and accuracy will improve health outcomes that people and communities depend on now and in the future.

Thermo Fishers clinical research business is a leading global contract research organization and world leader in serving science. We are passionate deliberate and driven by our mission to enable our customers to make the world healthier safer and cleaner.

Within our Analytical Services team we have a functional service provider solution which is a unique partnership that allows our customers to leverage the experience of our staff while allowing you the employee to gain direct experience working onsite at a pharmaceutical/ biopharmaceutical company all while maintaining full-time benefits.
Location: 100% onsite in Cambridge MA

The non-clinical bioanalytical team at our client site is searching for a Sr Scientist to join the team developing running and overseeing custom bioanalytical assays for research and development purposes. Assay applications will include pharmacokinetic (PK) assays in a non-regulated setting using mass spectrometry and immunoassay. This is a dynamic role where this lead scientist will get to wear multiple hats in discovery bioanalysis.

Key Responsibilities

• Be a pioneer in setting up bioanalytical workflows through scientific acumen relation building and efficient execution on goals.
• Design develop and qualify PK assays in preclinical setting.
• Work on simple or complex biologics and oligonucleotide bioanalysis
• Develop sample preparation approaches such as protein precipitation solid phase extraction Immunoprecipitation enzymatic digestions etc.
• Develop LC-MS/MS and LC-HRMS for intact protein analysis middle-up approach or bottom-up approach.
• Develop immunoassay methods using techniques such as MSD SIMOA Gyros etc.
• Coordinate outsourcing activities at CRO by monitoring method development qualification and sample analysis by LC-MS and LBA.
• Use these methods to characterize pharmacokinetic profile of constructs including integrity analysis.
• Participate in project team discussions and provide bioanalytical inputs to drug discovery efforts.
• Report and discuss bioanalytical results with integrative knowledge of how the data contributes to the drug development process.
• Actively contribute to scientific discussions.

Basic Qualifications:

• Has a Ph.D. in biochemistry biotechnology pharmaceutical sciences or related health sciences.
• 0- 2 years of experience working in a bioanalytical lab.
• Expertise in various mass spectrometry platforms including high resolution mass spectrometry (time of flight and orbitrap) and triple quadrupole mass spectrometry
• Good understanding of protein analysis on platforms such as Thermo Waters Sciex.
• Experience with different extraction techniques for quantitation of proteins in biological matrices (plasma and tissues).
• Knowledge of proteomics tools such as handling queries on protein databases and protein sequence analysis.
• Preferred to have working experience on ligand binding assays.
• Ability to present and write scientific documents including project team documents study reports posters and scientific publications.
• Ability to identify solutions to challenges scientifically and through inter-personal skills.
• Scientific curiosity appetite for teamwork and problem-solving skills

In some cases an equivalency consisting of a combination of appropriate education training and/or directly related experience will be considered sufficient for an individual to meet the requirements of the role.

Preferred Knowledge Skills and Abilities:

• 1- 2 years of experience working in a bioanalytical lab within a CRO
• Maintaining e-lab notebook
• Knowledge of proteomics tools such as handling queries on protein databases and protein sequence analysis.

Working Environment:

• Below is listed the working environment/requirements for this role:
• Able to communicate receive and understand information and ideas with diverse groups of people in a comprehensible and reasonable manner.
• Able to work upright and stationary and/or standing for typical working hours.
• Able to lift and move objects up to 25 pounds
• Able to work in non-traditional work environments.
• Able to use and learn standard office equipment and technology withproficiency.
• May have exposure to potentially hazardous elements including potentially infectious agents typically found in healthcare or laboratory environments.
• Able to perform successfully under pressure while prioritizing and handling multiple projects or activities.

We offer competitive remuneration annual incentive plan bonus healthcare and a range of employee benefits. Thermo Fisher Scientific offers employment with an innovative forward-thinking organization and outstanding career and development prospects. We offer an exciting company culture that stands for integrity intensity involvement and innovation!