Director, Global Supply Chain – Operational Excellence (LEAN)

Cytokineticsis a specialty cardiovascular biopharmaceutical company building on its over 25 years of pioneering scientific innovations in muscle biology and advancing a pipeline of potential new medicines for patients suffering from diseases of cardiac muscle dysfunction.

The Senior Manager of Operational Excellence (OpEx) is a key leadership role responsible for driving end-to-end process improvement operational efficiency and organizational capability building across Supply Chain External Manufacturing and Technical Operations within the pharmaceutical manufacturing network. This role will partner with internal and external stakeholders to deliver transformational initiatives ensure robust supply performance and enhance the companys ability to deliver high-quality medicines to patients reliably and cost-effectively.

The ideal candidate brings expertise in Lean Six Sigma pharmaceutical manufacturing processes (including cGMP) and the unique challenges of managing a global external manufacturing and supply network.

Responsibilities

Lead Operational Excellence Strategy & Execution

• Develop and execute the Operational Excellence roadmap for Supply Chain External Manufacturing and Technical Operations aligned with business goals and priorities.
• Drive transformational initiatives that enhance reliability agility and cost-effectiveness of the end-to-end supply network.
• Embed a culture of continuous improvement across internal teams and external partners.
• Monitor industry trends and benchmark performance to sustain competitive advantage in operational practices.

Process Improvement & Performance Optimization

• Identify prioritize and implement process improvement opportunities to enhance service reduce costs and ensure compliance across planning sourcing manufacturing and distribution.
• Facilitate cross-functional projects using Lean Six Sigma Value Stream Mapping and other proven methodologies.
• Support Technical Operations in problem-solving initiatives by coaching team leads to effectively utilize fit-for-purpose frameworks for identifying root cause(s).
• Standardize and digitize key supply chain and manufacturing processes to improve visibility control and decision-making.

External Manufacturing & Supplier Excellence

• Collaborate with CMOs/CDMOs and internal stakeholders to assess and improve external manufacturing performance through systematic KPI reviews and improvement plans.
• Lead joint improvement initiatives with external partners while ensuring cGMP and regulatory compliance.
• Build strong relationships and foster a culture of collaboration and continuous improvement with suppliers and contract manufacturers.

Tier Management & Visual Performance Management

• Design implement and sustain a Tiered Management System (Tier 13) across Supply Chain External Manufacturing and Technical Operations to enable effective daily weekly and monthly performance management.
• Deploy visual management tools and performance dashboards at each tier level to drive accountability transparency and fast problem resolution.
• Train and coach teams and partners in daily management practices visual controls and structured problem-solving.
• Ensure escalation processes and feedback loops are effective and standardized across the network.

Capability Building & Change Leadership

• Build organizational capabilities by developing and delivering training on Operational Excellence tools and methodologies to internal teams and external partners.
• Coach functional and site leaders in OpEx mindset and practices to enable self-sufficiency and sustained improvements.
• Lead change management efforts to overcome resistance and embed new ways of working.
• Act as a role model for continuous improvement demonstrating a data-driven collaborative and solution-oriented approach.

Qualifications & Experience

• Bachelors degree in Engineering Supply Chain Management Life Sciences or related field required; Masters degree or MBA preferred.
• Minimum 810 years of experience in a regulated healthcare industry segment (e.g. pharmaceutical development supply chain manufacturing medical device or technical operations with at least 510 years in operational excellence continuous improvement or similar leadership roles.
• Strong understanding of manufacturing and supply chain processes cGMP regulatory requirements and the complexities of external manufacturing.
• Certified Lean Six Sigma Black Belt (or equivalent) strongly preferred.
• Proven track record of delivering measurable improvements in operational performance cost reduction and process efficiency.
• Experience managing and improving external manufacturing or supplier relationships in a regulated industry.
• Exceptional project management change management and facilitation skills.
• Excellent communication influencing and stakeholder management abilities across all organizational levels and with external partners.
• Ability to thrive in a fast-paced matrixed and global environment.

Competencies

• Strategic thinking with a hands-on approach.
• Results-oriented and data-driven decision-making.
• Strong analytical and problem-solving skills.
• Ability to lead without authority and drive collaboration.
• Passion for excellence and continuous improvement.

Our passion is anchored in robust scientific thinking grounded in integrity and critical thinking. We keep the patient front and center in all we do all actions and decisions are in service of the patient and their caregivers. We champion integrity ethics doing the right thing and being our best selves.

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Pay Range:

Our employees come from different backgrounds and we celebrate those differences. We are looking for the best candidates for our open roles but do not expect applicants to meet every qualification in order to be considered. If you are excited about what you could accomplish at Cytokinetics and believe you can add value to our team we would love to hear from you.

Please review ourGeneral Data Protection Regulation (GDPR) policyPRIOR to applying.

Our passion is anchored in robust scientific thinking grounded in integrity and critical thinking. We keep the patient front and center in all we do all actions and decisions are in service of the patient and their caregivers. We champion integrity ethics doing the right thing and being our best selves.

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Cytokinetics is an Equal Opportunity Employer