Senior Statistical Geneticist

Our Future Health will be the UKs largest ever health research programme bringing people together to develop new ways to detect prevent and treat diseases. Diseases like cancer dementia diabetes and heart disease affect the lives of many people in our communities. Our goal is to create a world-leading resource for health research to improve our understanding and spot the patterns of how and why common diseases start so treatments can begin sooner and be more effective.

Were hiring a Senior Statistical Geneticist to join our growing molecular epidemiology division helping us to build refine and expand our genetic data repository and the range ofgenotyping-derivedgenetic data productsweofferto researchers.The successful applicant will apply their methodological and quantitativeexpertisein genetic data analysis to help deliver UKs largest ever health research programme.

The SeniorStatistical Geneticistwillwork withthe Director ofScience and Molecular Epidemiologyto leadprojectsingenerationanalysis anddownstreamuseof genetic dataincluding but not limited to:

• Ideation and development ofmodificationsmethodsand toolstoenhance the resource includingdevelopmentofnewtypes ofgeneticdata products.
• Supportindelivery ofgenetic data related initiatives that require expert-levelknowledge and skills in statistical methodologiesforgenetic data analysis.
• Evaluation ofour data repository in humangeneticsresearch usecases.
• Support otherstatistical geneticistsanddeliveryteamsmanaginggenotyping operationsdevelopingand releasingdata products and enhancingresearcherexperience.

This will require you to:

• Ownthetechnical specification and design history of our custom bead chip genotyping array and the end-to-endhigh-throughputgenotyping assayfordata collection and downstream processing.
• Act as theseniorgeneticsexpertand scientific project leadindelivery ofkeyscientific objectivesbytheLabs-to-Data (L2D) Working Group and theGenetic Data(GD)squad collaborating withlab operations quality assurance data operations programmemanagers productmanagers software and data engineers andother Science team members.
• Lead the design planningand executionofresearchstudiesinpopulation geneticsandgenetic epidemiologyusing Our Future Healthgeneticdatatoevaluatecompare andstress-testtheresourcepipelines platformsand theresearcherenvironment.
• Leadadaptation and development of new research methodologies and materials to support genetic epidemiology work by the team.
• Support otherstatistical geneticists in troubleshooting genetic data resultsbyidentifyingroot causesproposing mitigation strategies andrecommendingpipeline improvementsbased ondeep datainsights.
• Supportdevelopment ofexternally facing datasets documentsand toolsto guideresearcherson the availability and utility of data and samplesand to meet relevant quality and regulatory requirements.
• SupportRecontactandEngagementteams inevaluating participant genotype data forprojects involvingrecall-by-genotypeandfeedbackofgenetics-based health insights.
• Attendnational meetings and conferences both as a representative of Our Future Health and todisseminateresearch findings.
• Demonstrate support oforganisationalcompliance requirements including policies procedures and controls.

Essential:

• A PhDwith 5 yearspost-doctoral experience(or equivalent)in statistical geneticsbiostatisticsbioinformaticsgeneticepidemiology or acloselyrelated subject.

• Significantexperience in bioinformatics and analysis of large-scale genetic data including genome-wide association studies multi-ancestry analyses andpolygenic risk scoring methodologies.

• Excellent understanding of statistical concepts and methods in genetics and genetic epidemiology.

• Significant experienceindesigning planning andconducting scientific studies both independently andaspart of an interdisciplinary team.

• Experienceinin-depthraw geneticdata QC analysis.

• Proficiencyinstandardcomputationaltools ofstatisticalgenetics and with programming and scripting languages (e.g.R Python bash)

• Excellent prioritisation and workload management skills.

• Excellentwritten and verbalcommunication skills including the ability tomanageprojectdocumentationpresentcomplexresearchconceptsand resultsto lay audienceandwritescientific manuscripts.

Desirable:

• Experienceinworking with genotyping data

• Experienceinworking withwhole-genomesequencingdata

• Experienceinworking in a product-focused iterative development cycle for data products ortrack recordof building data products in a product-focused agile development environment

• Experience in using DatabricksJupyterLabor other notebook-based analysis environment in the cloud

• Experienceinlarge-scalemultimodalmolecular epidemiology studies.

• Experience in following code best practices; code versioning code review GitHub etc

• Experienceinwritingpublicationsandpreparingscientificpresentations.

• Experience in working closely with external data suppliers to define service requirements.

• Experienceinworkingundera Quality Management System.

Lets prevent disease together.

Closing date for applications : 4th November at 5pm

We recommend you apply as soon as possible as occasionally due to high volumes of applications we need to close our postings early.

At Our Future Health we recognise the importance of having a diverse workforce and ensuring that all candidates regardless of their background have equitable access to our application process. We proactively encourage applicants who identify as having a disability neurodiversity or long-term health conditions to let us know if they require any reasonable adjustments as part of their application process.

If you do require any reasonable adjustments please email us at

• Salary from 65000
• Generous Pension Scheme We invest in your future with employer contributions of up to 12%.
• 30 Days Holiday Bank Holidays Enjoy a generous holiday allowance with the flexibility to take bank holidays when it suits you.
• Enhanced Parental Leave Supporting you during lifes biggest moments.
• Career Growth & Development 500 per year to spend on Learnerbly our learning platform plus regular appraisals and development opportunities.
• Cycle to Work Scheme Save 25-39% on a new bike and accessories through salary sacrifice.
• Home & Tech Savings Get up to 8% off on IKEA and Currys products spreading the cost over 12 months through salary sacrifice.
• 1000 Employee Referral Bonus Know someone amazing Get rewarded for bringing them on board!
• Wellbeing Support Access to Mental Health First Aiders plus 24/7 online GP services and an Employee Assistance Programme for you and your family.
• A Great Place to Work We have a lovely Central London office in Holborn and offer flexible and remote working arrangements.

Required Experience:

Senior IC