Research Fellow-PC-Autoimmune Neurology-Irani
Research Fellow-PC-Autoimmune Neurology-Irani
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Salary Not Disclosed
1 Vacancy
Job Description
The laboratory of Dr. Irani is seeking a highly motivated Postdoctoral Research Fellow to join the Protein Engineering and Biochemistry in Autoimmune Neurology Group in Jacksonville Florida. This position will support and expand ongoing research efforts in translational protein engineering towards curing and diagnosing autoimmune encephalitis neuromyelitis optica dementias and related neurological diseases. The successful candidate will continue and extend the research pipeline established by Dr. Stephan Steinke focusing on the production and characterization of patient-derived autoantigen-specific monoclonal antibodies autoantigen discovery and engineering and their combined use towards novel diagnostic tools under GLP/GCP-compliant frameworks.
Responsibilities
Process and manage clinical trial samples
Design produce and validate neuronal antigen proteins (baitbodies) for B-cell sorting and epitope mapping
Produce purify and modify IgG IgA and IgM monoclonal antibodies in-house using mammalian expression systems
Develop implement and maintain SOPs for antibody QC documentation and compliance
Collaborate with cross-functional teams and mentor junior scientists or technicians
Qualifications
Ph.D. in Biotechnology Immunology Molecular Biology or related field
Experience in antibody engineering protein purification and biochemistry
Understanding antibody sequence data (identification of V-genes and C-domains) and antibody data bases (e.g. VBASE IMGT etc.)
Antibody cloning experience (e.g. GoldenGate Gateway classic)
Hands-on experience with mammalian cell culture ELISA SDS-PAGE and affinity chromatography (e.g. ÄKTA)
Methods to epitope map autoantibodies and determine their functionalities
Familiarity with GLP GMP and GCP standards
Excellent communication and organizational skills
Proactive solution-oriented mindset with attention to scientific rigor and documentation
Preferred Qualifications
Knowledge of CNS-targeted immuno-engineering and autoimmune disease models
Prior work with protein production and immune epitope mapping
Familiarity with regulatory documentation and clinical trial sample workflows
Employment Type
Full-Time
