Research Fellow-PC-Autoimmune Neurology-Irani lab

Jacksonville, FL - USA

Monthly Salary: Not Disclosed

Posted on: 30+ days ago

Vacancies: 1 Vacancy

Job Summary

Description

The laboratory of Dr. Irani is seeking a highly motivated Postdoctoral Research Fellow to join the Protein Engineering and Biochemistry in Autoimmune Neurology Group in Jacksonville Florida. This position will support and expand ongoing research efforts in translational protein engineering towards curing and diagnosing autoimmune encephalitis neuromyelitis optica dementias and related neurological diseases. The successful candidate will continue and extend the research pipeline established by Dr. Stephan Steinke focusing on the production and characterization of patient-derived autoantigen-specific monoclonal antibodies autoantigen discovery and engineering and their combined use towards novel diagnostic tools under GLP/GCP-compliant frameworks.

Responsibilities
Process and manage clinical trial samples
Design produce and validate neuronal antigen proteins (baitbodies) for B-cell sorting and epitope mapping
Produce purify and modify IgG IgA and IgM monoclonal antibodies in-house using mammalian expression systems
Develop implement and maintain SOPs for antibody QC documentation and compliance
Collaborate with cross-functional teams and mentor junior scientists or technicians

Dr. Iranis faculty page: Research Fellow at Mayo Clinic is a temporary position intended to provide training and education in research. Individuals will train in the research program of a Mayo Clinic principal investigator. Qualified individuals will demonstrate the potential for research as evidenced by their training and peer-reviewed publications and should become competitive for national research grants. Upon background check and CCATS Executive Committee approval Research Fellow may have patient/research subject contact directly relating to and incidental to the original research program. Proof of English proficiency is required for J-1 Short-Term Scholars Research Scholars Professors Specialists and Student Interns sponsored by Mayo Clinic.

Qualifications

Ph.D. in Biotechnology Immunology Molecular Biology or related field
Experience in antibody engineering protein purification and biochemistry
Understanding antibody sequence data (identification of V-genes and C-domains) and antibody data bases (e.g. VBASE IMGT etc.)
Antibody cloning experience (e.g. GoldenGate Gateway classic)
Hands-on experience with mammalian cell culture ELISA SDS-PAGE and affinity chromatography (e.g. ÄKTA)
Methods to epitope map autoantibodies and determine their functionalities
Familiarity with GLP GMP and GCP standards
Excellent communication and organizational skills
Proactive solution-oriented mindset with attention to scientific rigor and documentation

Preferred Qualifications
Knowledge of CNS-targeted immuno-engineering and autoimmune disease models
Prior work with protein production and immune epitope mapping
Familiarity with regulatory documentation and clinical trial sample workflows

DescriptionThe laboratory of Dr. Irani is seeking a highly motivated Postdoctoral Research Fellow to join the Protein Engineering and Biochemistry in Autoimmune Neurology Group in Jacksonville Florida. This position will support and expand ongoing research efforts in translational protein engineerin...

Key Skills

Bioinformatics
Genetics
R
Biochemistry
Cell Biology
Research Experience
Statistical Software
Cell Culture
Molecular Biology
Data Analysis Skills
Flow Cytometry
Microscopy

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Mayo Clinic

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