Researcher position
Researcher position
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Job Description
About the position
Researcher position on the roles of mechanical strain in nuclear envelope dynamics and transition from liver steatosis to MASH.
A 2-year Researcher position (postdoctoral level) is available at the Department of Pediatric Research Oslo University Hospital Oslo and the Department of Molecular Medicine Institute of Basic Medical Sciences UiO. The position is affiliated with the research groups of Dr Gareth Sullivan and of Associate Professor Coen Campsteijn.
The position is funded by the South-Eastern Norway Regional Health Authority (HSØ) and is available from November 01 2025 for two years. Start date is negotiable.
We seek a highly motivated Post-doctoral candidate to uncover the molecular mechanisms that drives a healthy liver to Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) and Metabolic Dysfunction-Associated Steatohepatitis (MASH) a phenomenon that poses a major societal biomedical challenge. Despite intense research we lack fundamental insight in the molecular processes that underlie the etiology of MASLD and its progression to highly pathological states like MASH and ultimately hepatocellular carcinoma (HCC). Recent advances have started to reveal how biomechanical forces and alteration in nuclear structure directly control cell function identity and this project we will explore biomechanics forces nuclear stress and dysfunction as drives of MASLD and MASH. The project is an ongoing collaboration between the Sullivan and Campsteijn labs. The successful applicant will work in an interdisciplinary team together with an additional postdoctoral scientist hired on this project and in collaboration with the groups of Associate Professor Frode Norheim and Professor Knut Tomas Dalen.
Oslo University Hospital and the University of Oslo are workplaces with a great diversity. We believe this to be a crucial advantage for solving biomedical challenges and tasks in the best possible way. We aim for this diversity to be reflected among the applicants for our positions and we encourage all qualified candidates regardless of background to apply.Key information
Tasks and Responsibilities
The project focuses on using advanced induced pluripotent stem cell (iPSCs) models of MASLD and exploring their behaviour using a using a combination of genetics transcriptomics proteomics and advanced light microscopy to dissect the mechanistic underpinnings of MASLD/MASH.
Qualifications
We are looking for a highly motivated skilled and independent researcher with extensive hands-on experience in mechanistic cell biology with a focus on nuclear biomechanics and associated signaling cascades. The candidate should have the following qualifications:
- PhD in cell biology molecular biology biochemistry or equivalent
- High proficiency in fixed and live cell fluorescence microscopy and image analysis
- Extensive hands-on experience with proteomics approaches analysis and validation
- Strong experience in molecular and/cell biology techniques including cell culture and genetics (cloning mutagenesis stable transgenesis and knockouts)
- Experience with lipid biology and stem cells
Track record of scientific productivity (e.g. publications in international journals) - Experience with figure preparation and manuscript writing
- Research integrity motivation and willingness to learn new methods
- Excellent teamwork and communication skills
- Fluent in English (oral and written)
Personal characteristics
- Du er opptatt av medarbeiderskapet og kommunikasjon for å bygge gode relasjoner og nettverk i sykehuset.
- Du er en lagspiller og har evnen til å samarbeide på tvers av ulike fagmiljøer.
- Du er bruker- og pasientorientert for å sikre god pasientflyt og arbeidsprosesser.
- Du er utviklingsorientert og endringsvillig i en tid hvor vi bygger nye sykehus.
- Du er initiativrik og trives med endringer i en stor og kompleks organisasjon.
- Du er faglig og personlig trygg og arbeider selvstendig strukturert og ansvarsbevisst.
- Du har et ønske om faglig utvikling og tar initiativ til din egen opplæring og utvikling.
We offer
- An exciting/innovative research project within a collaborative and supportive team
- A stimulating environment with access to state-of-the-art imaging facilities
- A healthy balance between independent research and close mentorship
- Career development support and guidance
- A full-time two-year employment (2 years)
- Salary according to Oslo University Hospital guidelines
- A flexible family-friendly workplace that supports worklife balance
How to apply:
Submit your application through Webcruiter with the following documents:
Application letter (12 pages) detailing your motivation and suitability for the position.
Curriculum Vitae including a list of publications and a summary of relevant skills.
Contact information for two references from previous research environments.
Incomplete applications (missing any of the above documents) or applications not submitted via Webcruiter will not be considered.
Application deadline: October 8th 2025
Preferred start date: November 2025 (negotiable)
Contact information:
Inquiries about the positions can be directed to group leader Dr. Gareth Sullivan
Address: Oslo universitetssykehus HF Rikshospitalet Sognsvannsveien 20 0372 Oslo Norway
Contacts
About the employer
Employment Type
Full-Time
