Director, Translational Lead â Renal, Inflammation and Fibrosis
Director, Translational Lead â Renal, Inflammation and Fibrosis
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Job Description
Director Translational Lead Renal Inflammation and Fibrosis
At GSK we have bold ambitions for patients aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines combining our understanding of the immune system with cutting-edge technology to transform peoples lives. GSK fosters a culture ambitious for patients accountable for impact and committed to doing the right thing making sure that we focus our efforts on accelerating significant assets that meet patients needs and have the highest probability of success. Were uniting science technology and talent to get ahead of disease together.
Find out more: Our approach to R&D
Respiratory Immunology and Inflammation Translational Unit (RIITU) within RIIRU (Respiratory Immunology and Inflammation Research Unit) therapy area is accountable for end-to-end disease area translational science to inform therapy area and program level biomarker strategies (from preclinical to launch) to increase the probability of success from preclinical to clinical transitions and enable earlier and higher confidence asset related decisions. This includes generation of foundational data as well as disease biomarker development and validation that allow timely deployment of tools/biomarkers to support Proof of Mechanism (PoM) signs of clinical efficacy Proof of Concept (PoC) and pairing Mechanisms of Action (MoAs) with patient subtypes to predict responder populations. We are looking for a dynamic individual to excel in the following responsibilities.
Key Responsibilities:
Disease Biomarker Strategy Development and Delivery:
o Partner with the Clinical Teams Research Technologies and the Development organization with focus on Renal Inflammation and Fibrosis portfolio to identify establish biomarkers for decision making throughout clinical development phases and aligned with the overall research and development goals. This will include the identification prioritisation and validation of disease relevant biomarkers mechanistic/surrogate biomarkers patient stratification and differentiated response prediction their deployment into clinical studies and interpretation of data/results.
Translational Leadership:
o Provide strategic leadership contributing to deep understanding of Disease areas enabling the development and execution of translational research disease strategies to support the discovery and development of novel differentiated therapeutics including evaluation and diligence of business development opportunities.
Translational innovation:
o Evaluate novel techniques and technologies (i.e. spatial transcriptomics) to inform translational initiatives biomarker development and validation working in collaboration with platform teams and within a multi-functional matrix environment.
o Identify and guide validation of human assays (cells tissues and organs) to enhance human translation and predictive value through the application of resources such as the Human Cell Atlas disease tissue multi-omics data and genetic resources (external or proprietary).
Cross-functional Collaboration:
o Collaborate closely with cross-functional teams including the Translational Disease Teams Human Genetics & Genomics biology groups biomarker platforms Medicine Development Teams HBSM data-sciences regulatory affairs business development and commercial to ensure seamless integration of translational research and biomarker strategies across the drug development lifecycle.
External Partnerships:
o Establish and maintain strategic collaborations with academic institutions contract research organizations (CROs) and other external partners to access cutting-edge technologies tools reagents biosamples biomarker expertise and research capabilities.
o Foster a network of external experts and key opinion leaders to stay at the forefront of translational science and biomarker advancements across the industry.
o Contribute to evaluation and diligence of business development opportunities.
Matrix Leadership:
o Provide mentorship guidance and professional development opportunities to ensure a high-performing and motivated team.
o Manage disease and project level resources budgets and timelines to ensure the successful execution of projects and achievement of milestones and RITU objectives.
o Represent RITU at portfolio governance reviews providing critical input to pipeline and investment decision making.
Why you
Basic Qualifications:
We are looking for professionals with these required skills to achieve our goals:
Ph.D. in a relevant scientific discipline (e.g. Cell/Molecular Biology Genetics Pharmacology Physical Chemistry or related field)
Extensive experience in translational science and biomarker development ideally within the pharmaceutical or biotechnology industry.
Recognised translational/biomarker expert in scientific community through publications and contributions to the field.
Experience of translation and biomarkers implementation in Renal Inflammation and / or Fibrotic indications.
Experience of working in a clinical trial setting working as part of a clinical study and experience of authoring and oversight of clinical and regulatory documents
Knowledge of regulatory requirements industry standards best practices and compliance considerations in Translational Research and biomarker development and validation.
Broad knowledge in technologies and methods used in translational research.
Proven track record of program decision making through implementing biomarker strategies and delivering translational science insights in support of drug progression through clinical transition milestones.
Experience leading/managing external collaborations and evaluation of business development opportunities.
Strong management skills with the ability to prioritize and manage multiple objectives to meet timelines while maintaining attention to detail and high-performance standards.
Excellent inclusive matrix leadership skills with the ability to create psychological safety inspire and motivate a team towards achieving common goals.
Ability to adapt to a fast-paced and evolving research environment with strong problem-solving and critical-thinking skills.
Preferred Qualifications:
If you have the following characteristics it would be a plus:
Awareness of bioinformatic / computational methods supporting integrated analysis and interpretation of translational and biomarker-related data sets.
Work Location:
This role is based in the United Kingdom or the United States and offers a hybrid working model combining on-site and remote work flexibility.
Join us in shaping the future of translational science and making a meaningful impact on patients lives.
Why GSK
Uniting science technology and talent to get ahead of disease together.
GSK is a global biopharma company with a purpose to unite science technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade as a successful growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory immunology and inflammation; oncology; HIV; and infectious diseases to impact health at scale.
People and patients around the world count on the medicines and vaccines we make so were committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients accountable for impact and doing the right thing is the foundation for how together we deliver for patients shareholders and our people.
GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race color religion sex (including pregnancy gender identity and sexual orientation) parental status national origin age disability genetic information (including family medical history) military service or any basis prohibited under federal state or local law.
We believe in an agile working culture for all our roles. If flexibility is important to you we encourage you to explore with our hiring team what the opportunities are.
Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities contact us on or 0. The helpline is available from 8.30am to 12.00 noon Monday to Friday during bank holidays these times and days may vary.
Please note should your enquiry not relate to adjustments we will not be able to support you through these channels. However we have created a UK Recruitment FAQ guide. Click the link and scroll to the Careers Section where you will find answers to multiple questions we receive
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Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license GSK may be required to capture and report expenses GSK incurs on your behalf in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSKs compliance to all federal and state US Transparency requirements. For more information please visit the Centers for Medicare and Medicaid Services (CMS) website at Experience:
Director
Employment Type
Full-Time
Key Skills
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