Senior Scientist Early Discovery Nonclinical Safety Lead
Senior Scientist Early Discovery Nonclinical Safety Lead
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$ 105000 - 169050
1 Vacancy
Job Description
At Johnson & Johnsonwe believe health is everything. Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented treated and curedwhere treatments are smarter and less invasive andsolutions are our expertise in Innovative Medicine and MedTech we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow and profoundly impact health for more at
Job Function:
Discovery & Pre-Clinical/Clinical DevelopmentJob Sub Function:
Nonclinical SafetyJob Category:
Scientific/TechnologyAll Job Posting Locations:
San Diego California United States of AmericaJob Description:
Our expertise in Innovative Medicine is informed and inspired by patients whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.
Join us in developing treatments finding cures and pioneering the path from lab to life while championing patients every step of the way.
You will:
Assist in the application and design of Ai/ML based platform technologies to assess biology and molecule-based risk working with colleagues in Therapeutic discovery Data Science and IT.
Analyze results ofin silico in vitroandin vivotoxicology as well as of safety pharmacology studies and literature data apply strategic perspective to results and compile nonclinical safety assessments.
Represent NCS on global discovery project teams serving as the single point of contact within NCSS to the project team for safety toxicology expertise and guidance and as the interface between the project team and senior management.
Lead the early team of nonclinical safety and PK scientists (PSTS team) working on a project. Ensure the smooth transfer of necessary information to functional areas within PSTS in conjunction with the PSTS team.
Collaborate with multi-disciplinary project teams to validate prioritize and de-risk drug targets and early candidate molecules. Provide nonclinical findings target expression and target risk input to the clinical protocols informed consent forms and monitoring protocols.
Perform target risk assessments and develop fit-for-purpose plans to screen for and manage potential liabilities of novel targets and therapeutics.
Assist in development of nonclinical safety strategies for different modalities and/or routes of administration based on an integration of literature regulatory guidance and involvement with professional organizations to inform project advancement decisions.
In issue-resolution teams provide key contribution to hypotheses generation.
Develop drug development experience to effectively communicate across all levels with internal and external partners including with global regulatory authorities. This requires excellent communication and negotiation skills.
Participate in due diligence activities on potential L&A opportunities.
Qualifications
A Doctoral level degree (PhD DVM MD or equivalent) with concentration in pharmacology or related field and at least 1 years of pharmaceutical/biotech industry experience in discovery or pre-clinical safety assessment supporting discovery level projects and demonstrating progressively increasing responsibilities or a Masters level degree and at least 6 years of pharmaceutical/biotech industry experience.
Experience in target discovery validation and early safety risk assessment.
Experience with different therapeutic modalities such as small molecules peptides bi-specific antibodies RNA-targeting therapeutics cell-based therapy and/or gene therapy is preferred.
Experience representing toxicology/nonclinical safety on project teams is preferred.
Excellent oral and written communication skills is required.
Broad understanding of the drug discovery / development process is required.
The ability to critically evaluate interpret and integrate large datasets and literature is required.
Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race color religion sex sexual orientation gender identity age national origin disability protected veteran status or other characteristics protected by federal state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.
Johnson and Johnson is committed to providing an interview process that is inclusive of our applicants needs. If you are an individual with a disability and would like to request an accommodation please email the Employee Health Support Center () or contact AskGS to be directed to your accommodation resource.
The anticipated base pay range for this position is :
$105000-$169050Additional Description for Pay Transparency:
Subject to the terms of their respective plans employees and/or eligible dependents are eligible to participate in the following Company sponsored employee benefit programs: medical dental vision life insurance short- and long-term disability business accident insurance and group legal insurance. Subject to the terms of their respective plans employees are eligible to participate in the Companys consolidated retirement plan (pension) and savings plan (401(k)). This position is eligible to participate in the Companys long-term incentive program. Subject to the terms of their respective policies and date of hire Employees are eligible for the following time off benefits: Vacation 120 hours per calendar year Sick time - 40 hours per calendar year; for employees who reside in the State of Washington 56 hours per calendar year Holiday pay including Floating Holidays 13 days per calendar year Work Personal and Family Time - up to 40 hours per calendar year Parental Leave 480 hours within one year of the birth/adoption/foster care of a child Condolence Leave 30 days for an immediate family member: 5 days for an extended family member Caregiver Leave 10 days Volunteer Leave 4 days Military Spouse Time-Off 80 hours Additional information can be found through the link below. Experience:Senior IC
Employment Type
Full-Time
Key Skills
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