Senior Manager, Laboratory

The Macara laboratory consists of a diverse group of about 8 students and postdoctoral fellows who are pursuing cutting-edge research projects in stem cell biology high-end microscopy cancer biology and epithelial biology. The laboratory is situated in the Department of Cell and Developmental Biology MRB3 which provides a vibrant interdisciplinary environment for cutting-edge research. CDB is an interactive and highly collaborative department with a strong graduate student association outstanding core facilities a top-ranked developmental biology program and exceptionally strong faculty.

Key Functions and Expected Performance:

Daily management and organization of the laboratory.

• Ordering supplies keeping the laboratory inventory up to date making solutions and other reagents. Working with sales representatives obtaining quotes ordering equipment
• Maintains equipment and obtains service when required to include both science lab equipment and computers
• Works with purchasing agents and vendors to locate and requisition supplies and
• Helps manage budgets with funding of over $1 million/year.
• Provides oversight of research group activities ensuring proper record keeping and updates to the laboratory database.

• Trains graduate and undergraduate students and supervises their fellow researchers and post-doctoral fellows

• Sets up equipment for use in labs; ensures proper operation of equipment and reports operating deficiencies to supervisor; provides training to incoming students and postdoctoral fellows in equipment operation.
• Maintains high-end confocal fluorescence microscope trains users on using the instrument and associated software for multichannel timelapse video imaging. Interacts with Nikon technicians to ensure functionality of the instrument and works with the technicians to repair or order new parts.
• Works with VUIT and SOMBS IT personnel to maintain/upgrade our 100 TB server and two high-end workstations used for image analysis.
• Maintains mouse colony and oversees breeding genotyping and purchase of specific strains. Performs survival surgery tissue collection and processing and experiments using live primary cells from specific mouse strains. Trains new personnel in handling mice.
• Practices safety environmental and/or infection control methods.

Performs laboratory research projects.

• Works either alone (with minimal oversight from the PI) or with other laboratory personnel on research projects. Designs sets up and performs appropriate experiments in cell and molecular biology. Supervises graduate and undergraduate student research projects.
• Synthesizes analyzes and interprets data with minimal help with the goal of publishing in peer-reviewed journals.

Supervisory Relationships:

This position has supervisory responsibility for undergraduate and graduate students; this position reports administratively and functionally to the principal investigator

Education and Certifications:

• A Bachelors degree from an accredited institution of higher education is necessary.

• A Masters degree from an accredited institution of higher education is strongly preferred.

Experience and Skills:

• At least 6 years of experience working in a research laboratory is necessary.
• Technical skills including high-end confocal timelapse microscopy fluorescence activated cell sorting (FACS) lentiviral production and a range of cell culture and cell transfection/transduction methods in bacteria and mammalian cells are necessary.
• Experience in mouse handling breeding colony maintenance and survival surgery is necessary.
• A broad and detailed knowledge of modern molecular biology is necessary.
• Experience with ordering maintaining laboratory stock dealing with vendors and maintaining schedules is necessary.
• Ability to analyze and interpret scientific data and use statistical analysis is necessary.
• Ability to interact with students faculty and/or staff in a team environment is necessary.