Scientist, In vivo Pharmacology, Oncology Targeted Discovery
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Job Location:
Waltham, MA - USA
Monthly Salary:
Not Disclosed
Posted on:
14-08-2025
Vacancies:
1 Vacancy
Job Summary
Scientist In vivo Pharmacology Oncology Targeted Discovery
Are you passionate about oncology research and development Do you want to make a real impact by turning scientific ideas into life-changing medicines Join AstraZeneca as a Scientist in cancer pharmacology within our Oncology Targeted Discovery group in Waltham Massachusetts. Here youll be a vital part of a team dedicated to advancing in vivo pharmacology support. Your expertise will help establish mouse models and assay systems delivering crucial datasets that drive our drug discovery process forward.
Accountabilities:
In this laboratory-based role youll design execute and analyze in vivo and ex vivo experiments to evaluate the function and mechanisms of promising oncology drug candidates. Youll generate high-quality data to support cross-functional project teams working closely with senior scientists and project leaders. Your contributions will be essential to the progress of our oncology research programs and scientific publication goals. As an organized and motivated scientist youll enhance your knowledge in tumor biology pharmacology and cancer modeling while collaborating in a dynamic research environment.
Essential Skills/Experience:
- You must hold a BS/MS with at least three years of relevant research experience in biology pharmacology or a related discipline.
- You should have hands-on experience with in vivo oncology models which could include subcutaneous xenograft patient-derived xenograft (PDX) syngeneic or humanized mouse models.
- Experience performing in vivo pharmacology studies in these models - covering areas such as dose-finding tolerability PK/PD and basic efficacy studies - is required as is familiarity with standard dosing techniques including intravenous (IV) intraperitoneal (IP) and oral gavage (PO).
- Your laboratory skill set includes foundational in vitro techniques such as cell culture molecular biology immunoblotting flow cytometry or ELISA/MSD.
- You are able to collect document and clearly communicate experimental data with an understanding of its relevance to the broader objectives of drug discovery.
- You show initiative and can work both independently and collaboratively as part of a team.
- Strong verbal and written communication skills are essential as is the ability to follow guidance from senior team members.
Desirable Skills/Experience:
- Previous experience in the biotechnology or pharmaceutical industry particularly in oncology-focused roles is a plus.
- Familiarity with in vivo studies involving antibody-drug conjugates (ADCs) or with mouse models resistant to cancer therapies will be advantageous.
- Additional experience with syngeneic mouse models relevant to immuno-oncology participation in multi-spectral flow cytometry studies or assisting with the training of junior staff will also be beneficial.
- Some understanding of the industrial drug discovery process is desirable.
At AstraZeneca we are driven by curiosity and determination to transform the practice of medicine in Oncology. Our team is at the forefront of applying science to create new possibilities for patients living with cancer. With one of the broadest Oncology pipelines in the industry we offer opportunities to work with novel drugs and innovative approaches. We foster a collaborative environment where diverse perspectives are valued empowering everyone to step up and innovate. Join us on our mission to make paradigm shifts in treatment options and improve patient outcomes worldwide.
Ready to make a difference Apply now and be part of our journey to change the future of cancer treatment!
Date Posted
07-Jul-2025Closing Date
30-Aug-2025Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion starting with our recruitment process. We welcome and consider applications from all qualified candidates regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations please complete the section in the application form.
Key Skills
- Laboratory Experience
- Immunoassays
- Machine Learning
- Biochemistry
- Assays
- Research Experience
- Spectroscopy
- Research & Development
- cGMP
- Cell Culture
- Molecular Biology
- Data Analysis Skills
About Company
AstraZeneca is a global, science-led biopharmaceutical business and our innovative medicines are used by millions of patients worldwide.
