UNIV Staff Scientist II Pharmacology and Immunology

Medical University Of South Carolina

Job Location:

Charleston, SC - USA

Monthly Salary: Not Disclosed

Posted on: 30+ days ago

Vacancies: 1 Vacancy

Job Summary

Job Description Summary

The Mass Spectrometry Facility part of the I3 Omics Umbrella Core at the Medical University of South Carolina (MUSC) is seeking an experienced and self-driven proteomics expert to join our highly collaborative and supportive team. This Senior Scientist (SSII) position will assist in develop of a multi-omic platform for basic and translational research projects for MUSC investigators and external researchers. This will include developing state-of-the-art proteomic capabilities and facilitating the establishment of multi-omic platform including proteomics and metabolomics. Substantial experience in LC-MS/MS (Orbitrap & Astral MS)-based proteomic data acquisition data processing statistical and bioinformatic evaluation is required. Development of customized and/or state-of-the-art biochemical methods for sample preparation (for post-translational modifications plasma proteomics TMT-based proteomics nDIA) is essential. Evaluation and quality assessment of proteomic workflows to ensure high quality data is necessary. Excellent communication skills are required for working with investigators in the areas of cancer cardiovascular disease neurodegenerative disease and digestive and liver disease. Instrumentation in the Mass Spectrometry Facility includes a Thermo Scientific Easy1200 nLC-Orbitrap Fusion Lumos ETD/UVPD MS Easy1200 nLC Exploris 480 MS Vanquish Neo LC-Orbitrap Astral Zoom MS Vanquish HPLC Kingfisher Apex.

Entity

Medical University of South Carolina (MUSC - Univ)

Worker Type

Employee

Worker Sub-Type

Unclassified

Cost Center

CC001034 COM PHARM Operations CC

Pay Rate Type

Salary

Pay Grade

University-00

Pay Range

0.00 - 0.00 - 0.000

Scheduled Weekly Hours

Work Shift

Job Description

The Proteomics Center encompasses a multi-team environment with proteomics glycomics glycoproteomics and metabolomics analyses using LC-MS/MS instrumentation at the Mass Spectrometry Facility and Mass Spectrometry Imaging instrumentation in the Proteomics Center.

Job Duties:

35% Collaborate with multiple labs to design and execute proteomics projects. Plan develop and execute proteomic experiments to establish state-of-the-art workflows.

35% Analyze and interpret proteomic MS data acquired by DDA DIA nDIA and TMT using state-of-the art bioinformatic workflows.

10% Prepare reports co-author publications and present results at meetings and/or conferences. Contribute data to grant applications.

10% Assist in maintaining and troubleshooting LC-MS instrumentation and perform rigorous routine instrument quality control steps.

10% Assist with establishment of metabolomic services

MUSC Minimum Training and Experience:

A Ph.D. M.D. or equivalent with two years postdoctorate experience plus evidence of scholarly activity as demonstrated by at least five first author publications.

Preferred Experience:

At least 5 years of proteomics experience.
Ph.D in biological sciences chemistry or analytical chemistry.
Experience and knowledge of the operation and maintenance of liquid chromatography and mass spectrometry systems especially Thermo Orbitraps and Astral MS.
Extensive knowledge and practical experience with complex sample preparation for mass spectrometry workflows.
Extensive experience in quantitative mass spectrometry-based strategies for proteomic analyses. Hands-on experience with computational tools for proteomics data analysis including MSFragger MaxQuant ProteomeDiscoverer and Spectronaut or DIA-NN.

Preferred Knowledge Skills and/or Abilities:

Working knowledge of modern molecular biology and biochemistry techniques such as chromatography transfection Western blots and immunoprecipitation.
Basic understanding of R programming.
Strong written and oral communication skills in English.
Work positively and enthusiastically as part of a team.

Salary and Benefits:The current salary range is commensurate with experience and accomplishments.

Additional Job Description

Physical Requirements: (Note: The following descriptions are applicable to this section: Continuous - 6-8 hours per shift; Frequent - 2-6 hours per shift; Infrequent - 0-2 hours per shift) Ability to perform job functions in an upright position. (Continuous) Ability to perform job functions in a seated position. (Continuous) Ability to perform job functions while walking/mobile. (Frequent) Ability to climb stairs. (Infrequent) Ability to work indoors. (Continuous) Ability to work in all cold temperature extremes i.e. spot coolers. (Frequent) Ability to bend at the waist. (Frequent) Ability to twist at the waist. (Frequent) Ability to perform pinching operations. (Continuous) Ability to fully use both hands/arms. (Continuous) Ability to perform repetitive motions with hands/wrists/elbows and shoulders. (Continuous) Ability to fully use both legs. (Continuous) Ability to reach in all directions. (Continuous) Possess good finger dexterity. (Continuous) Ability to maintain tactile sensory functions. (Continuous) Ability to maintain good olfactory sensory function. (Continuous) Ability to lift and carry 30 lbs. unassisted. (Frequent) Ability to lift objects up to 30 lbs. from floor level to height of 72 inches unassisted. (Frequent) Ability to lower objects up to 30 lbs. from height of 72 inches to floor level unassisted. (Frequent) Ability to push/pull objects up to 50 lbs. unassisted. (Infrequent) Ability to lift and carry objects up to 30 lbs. a distance of five (5) floors and to outlying buildings. (Frequent) Ability to maintain 20/40 vision corrected. (Continuous) Ability to see and recognize objects close at hand. (Continuous) Ability to see and recognize objects at a distance. (Continuous) Ability to match or discriminate between colors. (Continuous) Ability to determine distance/relationship between objects; depth perception. (Continuous) Good peripheral vision capabilities. (Continuous) Ability to maintain hearing acuity with correction. (Continuous) Ability to perform gross motor functions with frequent fine motor movements. (Continuous) Ability to be qualified physically (by medical personnel) for respirator use initially and annually. Ability to work alone in isolated areas such as darkrooms. (Frequent) Additional New Requirements: Ability to obtain and maintain a valid drivers license. Computer literacy. Ability to work rotating shifts as required. Ability to work overtime as required. Ability to learn and use new processes tools and equipment as required.

If you like working with energetic enthusiastic individuals you will enjoy your career with us!

The Medical University of South Carolina is an Equal Opportunity Employer. MUSC does not discriminate on the basis of race color religion or belief age sex national origin gender identity sexual orientation disability protected veteran status family or parental status or any other status protected by state laws and/or federal regulations. All qualified applicants are encouraged to apply and will receive consideration for employment based upon applicable qualifications merit and business need.

Medical University of South Carolina participates in the federal E-Verify program to confirm the identity and employment authorization of all newly hired employees. For further information about the E-Verify program please click here: Experience:

Staff IC

Job Description SummaryThe Mass Spectrometry Facility part of the I3 Omics Umbrella Core at the Medical University of South Carolina (MUSC) is seeking an experienced and self-driven proteomics expert to join our highly collaborative and supportive team. This Senior Scientist (SSII) position will ass...