Associate Principal Scientist â Biologics AI Innovation
Associate Principal Scientist â Biologics AI Innovation
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1 Vacancy
Job Description
About the Role:
We are seeking an experienced and visionary Associate Principal Scientist to drive Biologics AI innovation at AstraZenecas US R&D centers in Waltham MA or Gaithersburg MD. This pivotal leadership role will focus on integrating state-of-the-art artificial intelligence with wet-lab discovery enabling synergistic advances in biologics engineering. You will work collaboratively across computational and experimental functions influence the direction of AI-driven research and champion the seamless collection and translation of high-quality data for the design of next-generation biotherapeutics.
Key Responsibilities
As an Associate Principal Scientist your main responsibilities will be:
Lead and design AI strategies for biologics discovery and engineering with a focus on AIwet lab integration and accelerated translation of computational findings to experiments.
Oversee and guide the development of innovative models including protein language models structure prediction models de novo protein design and multi-modal approaches combining sequence structure and biological activity data.
Act as a scientific bridge and champion for cross-functional collaboration between AI scientists and wet-lab teams within the US and in close alignment with global teams.
Drive the generation curation and utilization of high-quality wet-lab data; provide actionable feedback to experimental teams for optimizing data production for ML applications.
Evaluate recommend and implement emerging technologies adopting best practices in data science computational biology and protein engineering to ensure world-class innovation and delivery.
Mentor junior scientists and provide scientific leadership in biologics AI fostering a collaborative innovative and high-performing team environment.
Communicate progress challenges and strategy to stakeholders at all levels contributing to strategic decision-making and representing the team in internal and external collaborations.
Author scientific publications contribute to intellectual property and serve as an ambassador for AstraZeneca in the external scientific community through presentations and collaborations.
Required Qualifications
Master and 2 years experience or Phd and 0 years of experience in mathematics physics computer science statistics bioinformatics or a related discipline with substantial academic or industry experience in the application of AI/ML to biological problems.
Deep expertise and hands-on track record in developing and deploying machine learning and deep learning models for protein sequence and structure analysis biologics design or related fields.
Demonstrated experience in leading initiatives that combine computational modeling with experimental biology ideally in a therapeutics or biopharmaceutical setting.
Strong programming and analytical skills including proficiency with Python and major AI/ML frameworks such as TensorFlow PyTorch or JAX.
Familiarity with large-scale data engineering cloud computing and FAIR data principles.
Excellent communication and leadership skills with proven success in cross-functional environments and multi-site collaborations.
Demonstrable record of scientific innovation as evidenced by publications patents or successful project delivery in biologics discovery or engineering.
Preferred Qualifications
Experience with structural informatics structural biology or structure-based rational design.
Experience with molecular dynamic simulation and structure modeling.
Experience with multi-modal learning agentic AI or the integration of heterogeneous biological data formats.
Prior leadership mentoring or line management experience in industrial or academic R&D.
Recognized presence in the external scientific community through publications conference presentations or collaborations.
Why Join Us
As part of AstraZenecas dynamic US biologics R&D community you will play a critical role in shaping the future of AI-driven biologics discovery and engineering. Collaborating across cutting-edge computational and experimental teams youll drive innovation that brings transformative medicines to patients around the world. You will be supported by a collaborative inclusive and empowering environment with unparalleled opportunities for scientific impact and personal growth.
Date Posted
07-Jul-2025Closing Date
Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion starting with our recruitment process. We welcome and consider applications from all qualified candidates regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations please complete the section in the application form.Required Experience:
Staff IC
Employment Type
Full-Time
