Senior Research Scientist in Genetic Manipulation
Senior Research Scientist in Genetic Manipulation
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Job Description
Salary for this Role:
From 45795 with benefits subject to skills and experience
Job Title:
Senior Research Scientist in Genetic ManipulationReports to:
Graham DuddyClosing Date:
26/Aug/2025 23.59 GMTJob Description:
Senior Research Scientist in Genetic Manipulation
Details of the role:
Working pattern: Monday Friday. this is a full-time permanent position on Crick terms and conditions
About us
The Francis Crick Institute is Europes largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent diagnose and treat illnesses such as cancer heart disease infectious diseases and neurodegenerative conditions.
The Crick is a place for collaboration innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure cutting-edge facilities and a creative and curious culture. Weve removed traditional boundaries of departments divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to take risks and carry out high-quality pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy.
About the role
The Genetic Modification Services (GeMS) provide a breadth of specialist skills and resources for the design creation production storage and use of genetically altered animals germplasms and cell lines together with ancillary techniques.
The services that GeMS currently compromises are: molecular biology micromanipulation surgical expertise cryopreservation of rodent and aquatics germplasms assisted Reproductive techniques such as IVF AI ICSI Rederivation of live and frozen imports & exports to and from the Crick and murine stem cell culture.
As the GeMS Senior Research Scientist (SRS) you will play a pivotal role in developing new animal models and leading projects from start to finish. An in-depth understanding of molecular biology cell culture genetic modification and mouse genetics is required. You will also ensure that the 3Rs principles for in vivo researchreplacement reduction and refinementunderpin all work undertaken.
This could be the perfect opportunity for you to join the team if you have a PhD. or MSc/BSc with a proven track record and five years of experience in a relevant field including in-depth knowledge and demonstrable skills genome modification gene targeting and the use of the CRISPR-Cas systems.
What you will be doing
As a BRF GeMS Senior Research Scientist at the Crick you will:
- Design and plan complex cloning strategies genotyping strategies and the generation of molecular reagents for the production and validation of new genetically modified alleles predominantly using CRISPR-based genetic manipulation.
- Use implement support and troubleshoot the execution of core molecular biology and cell culture techniques and implement novel methodologies within the group to improve production efficiency and accuracy.
- Support the Senior Manager in the design and implementation for the creation of new animal models. Take responsibility not only for a subset of GeMS projects but also take a wider proactive view across the entire GeMS portfolio.
- Plan and co-ordinate the in vivo gene delivery pipeline for the direct manipulation of the mouse zygote and the gene targeting pipeline for manipulation of mouse embryonic stem cells. Engage in out of hours cell culture work rota.
- Trouble shoot problematic experiments across the GeMS portfolio.
Please see the full job description here.
About you
You will have:
- PhD or MSc/BSc with a proven track record and 5 years experience in a relevant field.
- Possess considerable relevant experience with a track record of achievement and demonstrable skill in genome engineering molecular biology and mammalian cell culture.
- Exhibit knowledge understanding and practical experience of CRISPR/CAS design and associated techniques.
- Experienced in the use genome browsers DNA analysis software and CRISPR Cas guide on/off target specificity software.
- Commitment to continued professional development (CPD).
- Experience of contributing effectively to the work of a team with a flexible and collaborative approach.
About Working at the Crick
Our values
Everyone who works at the Crick has a valuable role to play in advancing the Cricks mission and shaping our culture!
- We arebold. We make space for creative dynamic and imaginative ideas and approaches. Were not afraid to do things differently.
- We areopen. Were highly collaborative and interactive and make sure our activities are visible to the outside world.
- We arecollegial. We show respect for one another work cooperatively and support the wider community.
At the Francis Crick Institute we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued respected and empowered to succeed regardless of their background identity or personal circumstances. We actively encourage applications from individuals of all genders ethnicities abilities and experiences. Weare aDisability Confident: Committedemployer andwant to ensure that everyone can apply and be part of our recruitment processes and sowellmake reasonable adjustments if you need them - just let us know when you apply. If you needassistancewith applying (i.e. would like to apply by phone or post)please email:
Find out more about life at the Crick.
Please note you must meet the essential criteria listed within the Role Profile to have your application reviewed.
We reserve the right to withdraw this advert at any given time due to the number of applications received.
What will you receive
At the Francis Crick Institute we value our team members and are proud to offer an extensive range of benefits to support their well-being and development:
- Visas: Applicants for this role will be eligible for sponsorship to work in the UK
- Generous Leave: 28 days of annual leave plus three additional days over Christmas and bank holidays.
- Pension Scheme: Defined contribution pension with employer contributions of up to 16%.
- Health & Well-being:
- 24/7 GP consultation services.
- Occupational health services and mental health support programs.
- Eye care vouchers and discounted healthcare plans.
- Work-Life Balance:
- Back-up care for dependents.
- Childcare support allowance.
- Annual leave purchase options.
- Crick Networks offering diverse groups support community and inclusive social events.
- Perks:
- Discounted gym memberships bike-to-work scheme and shopping discounts.
- Subsidised on-site restaurant and social spaces for team interaction.
Required Experience:
Senior IC
Employment Type
Full-Time
