Translational Science Lead

Job Title: Translational Science Lead

Introduction to role

Are you ready to bridge the gap between bench science and bedside clinical practice At AstraZeneca our Translational Science Lead (TSL) plays a pivotal role in our Precision Medicine groups within the Translational Science and Experimental Medicine (TSEM) department. We are committed to understanding disease mechanisms at the molecular level identifying the most relevant targets and driving patient stratification in Respiratory & Immunology (R&I) diseases. As a TSL you will lead the development of translational science strategies ensuring target engagement and human target validation and delivering evidence to confirm proofofmechanism in clinical trials. This role spans from conceptual target ideas through early drug development and all clinical phases including Phase 3 and life cycle management opportunities. Join us in our mission to bring precision medicine propositions to the clinic!

Accountabilities

Develop and integrate translational science strategies for R&I projects and clinical studies focusing on human target validation target engagement and precision medicine.
Build mechanistic understanding of targets and diseases through innovative experimental methods and technologies.
Establish translational evidence packages for new targets using public and proprietary biobanks.
Identify and enable PoM biomarkers to demonstrate target engagement at First Time In Human (FTIH).
Deliver precision medicine strategies to identify patients most likely to benefit from our medicines.
Represent TSEMs translational and precision medicine strategy in investment decisions and governance interactions.
Integrate translational and precision medicine strategy into key clinical documents.
Interpret biomarker data from clinical studies to enhance patient outcomes.
Contribute to regulatory and health authority responses authoring submission document sections related to Mode of Action PK/PD and precision medicine.
Prepare and review scientific publications to support publication and marketing strategies.

Education/Experience

PhD or MD equivalent with a strong experimental drive and background in relevant scientific field
Postdoc experience or otherwise relevant scientific research experience
Experience in an academic and/or industry setting
Strong publication record

Required Skills/Experience

Proven ability to deliver in precision medicine and human target validation applied to drug discovery
Excellent understanding of Immunology and/or Respiratory therapy areas and disease biology
Experience with patient stratification precision medicine and biomarker invention
Familiarity with target engagement biomarkers and PoM biomarker implementation
Broad understanding of relevant technologies and methodologies with excellent scientific laboratory skills
Strong skills in hypothesis forming testing and drawing conclusions from experimental data
Demonstrated leadership skills and ability to be a selfstarter
Strong team working skills with a proven track record of collaborative work
Excellent written oral presentation and interpersonal skills

At AstraZeneca we are driven by our passion for science and our commitment to making a difference. We are fusing data and technology with the latest scientific innovations to achieve breakthroughs that can redefine whats possible in healthcare. Our inclusive environment encourages collaboration across academia biotechs and industry allowing us to create the greatest impact on disease. With opportunities for continuous learning and career development we empower our team members to explore without limits.

If you are ready to make a significant impact on patients lives through innovative science apply now to join our team at AstraZeneca!

So whats next

Please complete your application before the below closing date (27th May 2025)

We look forward to hearing from you.

Where can I find out more

Follow AstraZeneca on LinkedIn AstraZeneca on Facebook AstraZeneca on Instagram us today and be a part of the change!

Date Posted