Principal Scientist in Chemical Induced Proximity
Principal Scientist in Chemical Induced Proximity
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$ 138320 - 262080
1 Vacancy
Job Description
The Worlds Brightest Minds Always Innovate
At St. Jude Childrens Research Hospital we know what can be achieved when the brightest scientific minds face the fewest barriers. Thats why we provide worldclass facilities. Stateoftheart technologies. Extraordinary support. And a collaborative benchtobedside environment where you can see firsthand how your science translates into survival for the children we serve. Quite simply at St. Jude we encourage you to dream big and stop at nothing when it comes to finding cures and saving children.
The incumbentwill be responsible for driving strategic decisions throughout the various stages of the small molecule drug discovery process focusing on chemically induced proximity platforms. Experience with use of computational tools including Artificial Intelligence (AI) and Machine Learning (ML) in virtual screening small molecule design and optimization is preferred.
- Set up the chemistry strategy for projects and advance drug discovery programs by collaboratively interacting crossfunctionally within departmental collaborative centers and various departments at the institution. Lead and manage a team of scientists and largescale multidisciplinary projects through proactive research collaboration and provide direction in specific area of expertise.
- Contribute to recruiting and growing the team guiding and mentoring junior staff.
- Stay at the forefront of induced proximity platforms including but not limited to PROTACs molecular glues and other bifunctional or allosteric modulators.
- Evaluate new technologies chemical tools and screening platforms that can accelerate the development of proximitybased therapeutics.
- Design and optimize focused chemical libraries to identify hits leads and drug candidates that induce selective protein interactions and cellular phenotypic changes.
- Maintain collaborative partnerships while ensuring recognition on collaborating publications and patents.
- Lead and manage a number of contract research organizations (CRO) and external chemistry partners across the globe.
- Oversee structureactivity relationship (SAR) studies to enhance potency selectivity and druglike properties of candidate molecules. Lead efforts to improve the pharmacokinetic pharmacodynamic and toxicological profiles of compounds in collaboration with ADMET and DMPK teams.
- Serve as functional expert in due diligences for assets inlicensing and discovery partnerships.
- Responsible for leading publication efforts in highimpact scientific journals.
- Experience in drug discovery in Pharma/Biotech industry highly preferred.
- Experience with computational design or AI/ML preferred.
- PhD with management experience preferred.
This is a senior leadership role with a focus on advancing cuttingedge drug discovery programs for childhood catastrophic diseases using the latest approaches in proximitybased targeting. Specifically based on the mechanistic basis ofdiseaseour goalis to develop unique chemical approaches (protein degraders synthetic gene regulators and/or functional effectors) to degrade or manipulate targets relevant to pediatric oncology neurodegenerative disordersand sickle cell disease.
Minimum Education and/or Training:
- Bachelors degree in relevant scientific area is required.
- PhD preferred.
Minimum Experience:
- Fifteen (15) years of relevant work experience is required with a Bachelors degree.
- Thirteen (13) years of relevant work experience is required with a Masters degree.
- Ten (10) years or relevant work experience is required with a PhD.
Better at Work. Better at Life.
When you work at St. Jude youll join a highly collaborative work culture that inspires you every day to be your opportunities for learning and growth you can shape a career path that is right for you while also enjoying all the benefits and stability of working for a worldclass institution. This includes worklife balance with generous paid timeoff and oncampus conveniences that make life a little easier. Join us and youll quickly see why St. Jude is consistently ranked by our employees on Glassdoor as a Best Place to Work.
Benefits
Your health and wellbeing are important to us. Thats why St. Jude Childrens Research Hospital provides employees with highquality benefits choices.
We are committed to ensuring our benefits are competitive and affordable. St. Jude continues to cover medical premiums for employees and offers low additional costs for dependents.
View all thebenefitsofferedincluding Medical & Prescription Drug Plans Dental Plan Vision Plan Financial Security Retirement Plan Living Well Employee Wellness Program Time Off Programs Educational Benefits Family Friendly Benefits and Benefits Unique to St. Jude.
Have More in Memphis
Get the best of bigcity amenities mixed with all the charm of a smalltown feel when you live in Memphis. From our worldrenowned music scene to our eclectic mix of food and people. Memphis is a place our employees are proud to call home. Our region enjoys a cost of living more than 20% lower than the national average and our state places no personal income tax on wages. Plus Memphians spend five hours less per year in their daily commute compared to the national average. Learn how you can Have More in Memphis.
Compensation
In recognition of certain U.S. state and municipal pay transparency laws St. Jude is including a reasonable estimate of the compensation range for this role. This is an estimate offered in good faith and a specific salary offer takes into account factors that are considered in making compensation decisions including but not limited to skill sets experience and training licensure and certifications and other business and organizational needs. It is not typical for an individual to be hired at or near the top of the salary range and compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current salary range is $138320 $262080 per year for the role of Principal Scientist in Chemical Induced Proximity.Explore our exceptional benefits!
No Search Firms
St. Jude Childrens Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.
Required Experience:
Staff IC
Employment Type
Full-Time
