Associate Director, Health Economics & Outcomes Research
Associate Director, Health Economics & Outcomes Research
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$ 163000 - 191500
1 Vacancy
Job Description
About Summit:
Ivonescimab known as SMT112 is a novel potential firstinclass investigational
bispecific antibody combining the effects of immunotherapy via a blockade of PD1 with the antiangiogenesis effects associated with blocking VEGF into a single molecule. Ivonescimab displays unique cooperative binding to each of its intended targets with multifold higher affinity when in the presence of both PD1 and VEGF.
Summit has begun its clinical development of ivonescimab in nonsmall cell lung cancer (NSCLC) with three active Phase III trials:
- HARMONi is a Phase III clinical trial which intends to evaluate ivonescimab combined with chemotherapy compared to placebo plus chemotherapy in patients with EGFRmutated locally advanced or metastatic nonsquamous NSCLC who have progressed after treatment with a 3rd generation EGFR TKI (e.g. osimertinib).
- HARMONi3 is a Phase III clinical trial which is designed to evaluate ivonescimab combined with chemotherapy compared to pembrolizumab combined with chemotherapy in patients with firstline metastatic NSCLC.
- HARMONi7 is a Phase III clinical trial which is intended to evaluate ivonescimab monotherapy compared to pembrolizumab monotherapy in patients with firstline metastatic NSCLC whose tumors have high PDL1 expression.
Ivonescimab is an investigational therapy that is not approved by any regulatory authority in Summits license territories including the United States and Europe. Ivonescimab was approved for marketing authorization in China in May 2024. Ivonescimab was granted Fast Track designation by the US Food & Drug Administration (FDA) for the HARMONi clinical trial setting.
Overview of Role:
Summit Therapeutics is seeking an Associate Director Health Economics & Outcomes Research to join our mission of developing Ivonescimab a novel and unique immunotherapy with the potential to help patients suffering from lifethreatening cancers.
The Associate Director of Health Economics and Outcomes Research (HEOR) will lead initiatives to generate and communicate evidence that enhances product value and informs access strategies. This position entails developing and executing comprehensive health economics outcomes research and realworld evidence (RWE) plans in alignment with medical affairs strategies clinical development objectives and commercial approaches to support product value propositions and optimize market access. The role is responsible for disseminating scientific evidence to inform providers payers populationbased decision makers (PBDMs) and patients about the value proposition of ivonescimab.
The ideal candidate will thrive in a fastpaced environment and be adept at collaborating with internal crossfunctional teams and external stakeholders.
Role and Responsibilities:
- Lead HEOR research activities including planning budgeting and on time execution
- Author and review protocols analytic plans reports and other study documents with independent critical thinking to ensure quality and completeness of output
- Implement global and regional HEOR strategies and projects to inform support and strengthen market access
- Assist with value demonstration tactics for Health Technology Assessment (HTA) including the EU Join Clinical Assessment (JCA) and payer assessments
- Maintain awareness of the quickly evolving global HTA and reimbursement landscape
- Lead the development and implementation of robust RWE studies economic models clinical outcome assessments (COAs) patient preference studies and other relevant research to meet value evidence needs
- Ensure evidence generation is conducted with a high level of scientific rigor and is in strategic alignment with crossfunctional teams
- Oversee the development of highquality publications posters and presentations to communicate HEOR findings effectively
- Collaborate with internal teams to package economic models and generated evidence into field materials that address payer and stakeholder priorities
- Develop and maintain strong alignment with the managed care liaison team to obtain insights from external stakeholders and adjust evidence generation plans accordingly
- All other duties as assigned
Experience Education and Specialized Knowledge and Skills:
- Bachelors degree (Masters PharmD or PhD) in Health Economics Epidemiology Outcomes Research Public Health or related field. Masters preferred.
- 8 years relevant experience in healthcare industry with direct experience in global value proposition development and interaction with payers HTA bodies relevant policymakers and strong patientcentered focus
- Previous experience in Oncology preferably nonsmall cell lung cancer (NSCLC)
- Understanding of the US market access landscape; familiarity with global reimbursement processes a strong plus
- Hands on experience in health economics health technology assessment (HTA) tools methods and filing SLRs ITCs statistical analyses RWE generation and economic modelling
- Strong analytical capabilities and excellent communication skills
- Ability to work collaboratively across diverse teams and manage multiple stakeholders
- Ability to be proactive enthusiastic and goal oriented
- Track record of peerreviewed publications
The pay range for this role is $163000$191500 annually. Actual compensation packages are based on several factors that are unique to each candidate including but not limited to skill set depth of experience certifications and specific work location. This may be different in other locations due to differences in the cost of labor. The total compensation package for this position may also include bonus stock benefits and/or other applicable variable compensation.
Summit does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact Summits Talent Acquisition team at to obtain prior written authorization before referring any candidates to Summit.
Required Experience:
Director
Employment Type
Full-Time
