Scientist Synthetic Biology (m/f/d)
Scientist Synthetic Biology (m/f/d)
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Job Description
At Roche you can show up as yourself embraced for the unique qualities you bring. Our culture encourages personal expression open dialogue and genuine connections where you are valued accepted and respected for who you are allowing you to thrive both personally and professionally. This is how we aim to prevent stop and cure diseases and ensure everyone has access to healthcare today and for generations to come. Join Roche where every voice matters.
The Position
Our vision is to create novel and highly differentiated medicines. To this end we discover and develop novel therapeutic antibodies and next generation biologics such as bispecific antibodies fusion proteins or AAV vectors for gene therapy. Our ambition is to deliver such novel molecules to patients with game changing clinical benefit.
In this challenging environment we are looking for a Scientist in Synthetic Biology (m/f/d) with a keen interest in the fields of rAAV gene therapies. You will join the department of Cell Technologies which belongs to a unit called Large Molecule Research within Roche Pharma Research and Early Development (pRED).
Job mission
Your work will focus on development and application of synthetic biology tools to improve current and future rAAV gene therapies. You have a strong background in the generation and utilization of genetically barcoded libraries (e.g. massive parallel reporter assays (MPRAs) or CRISPR screens) to run designbuildtestlearn cycles for engineering & optimization of genetic elements.
Your impact
- DESIGN & BUILD: You will design clone and characterize DNA barcoded libraries for various cuttingedge highthroughput screens
- TEST: You are an expert in preparation of sequencing ready NGS libraries and apply your skills to faithfully execute current protocols as well as establish new methods
- LEARN: Preferably you are experienced in either Bash R or Python to analyze and consolidate the generated data sets
Your profile
You thrive in and are dedicated to establishing a culture of mutual support crosstraining continuous learning and selforganization to meet project and functional goals. Furthermore you know how to prioritize how to create clarity and focus. Besides you have the following education and experience:
- A deep understanding of cuttingedge technologies for generation & screening of genetically barcoded libraries is necessary for this position. Ideally in the context of rAAV gene therapies.
- A University degree in biotechnology synthetic biology or similar area with PhD helps you to fulfill those tasks
- A strong background in molecular biology (e.g. plasmid design cloning and production of complex DNA libraries) as well as in NGS library preparations is required. Additional experience in FACSsorting and cell culture are optional.
- Ideally you have computational experience in analysing and handling various NGS datasets
- We can trust in your project management skills as well as in your precise and reliable execution of experiments
- Fluent English language skills are natural to you
Unwavering focus collaborative teamwork and exceptional delivery are key behaviors that drive our mission of doing now what patients need next. Together we can be transformative.
This position is temporary for two years.
Your final Scientific Career Ladder (SCL)Title will be evaluated according to your individual scientific experience. The latter also determines a possible employment under the collective agreement for academically educated employees.
Your application
Please upload your current resume and your latest certificates.
We are looking forward to your application!
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Employment Type
Full-Time
