Postdoctoral Researcher
Postdoctoral Researcher
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USD 71845 - 80000
1 Vacancy
Job Description
MitochondriaLysosome Crosstalk in Aging and Senescence Zhou Hansen and Andersen Labs
POSITION SUMMARY
The Zhou Hansen and Andersen Labs at the Buck Institute for Research on Aging are jointly seeking a highly motivated Postdoctoral Researcher to explore the molecular mechanisms of mitochondrialysosome crosstalk in aging and cellular senescence. This collaborative project spans multiple model systems from cellular models to multicellular organisms such as C. elegans to address how organelle dysfunction contributes to aging and agerelated diseases.
Mitochondrial dysfunction and lysosomal impairment are conserved hallmarks of aging and central drivers in neurodegenerative diseases such as Alzheimers. This position offers a unique opportunity to work at the interface of cell biology aging research and systemslevel analysis using a wide range of cuttingedge technologies:
- Genetic screening and molecular biology
- Superresolution and cryoelectron microscopy
- Highthroughput screening
- Quantitative image analysis and machine learning
QUALIFICATIONS
- Ph.D. in molecular biology cell biology biochemistry genetics neuroscience or a related field
- Strong experimental background in cellular or organismal models
- Prior experience with microscopy organelle biology or aging/senescence studies is a plus
- Ability to work independently and collaboratively in a highly interdisciplinary environment
- A highly collaborative innovative environment for aging research in theSan Francisco Bay Area
- $71845 $80000 postdoc salary range (commensurate with level & experience)
- Generous benefits package includes health insurance paid parental leave vacation/sick leave and 401(k) with a 5% employer match and student loan repayment option
Please submit a current CV 3 professional references and a cover letter addressing your past research experience plans and expectations for working in the labs. For questions contact Dr. Zhou via email (emailprotected).
Related publications from our labs
- Liu et al. Mitochondrialysosome coupling contributes to lysosome acidification and aging. In revision
- Yang et al. 2024. Autophagy protein ATG16.2 and its WD40 domain mediate the beneficial effects of inhibiting earlyacting autophagy genes in C. elegans neurons. Nature Aging 4 (2): 198212
- Chamoli et al. 2023. A druglike molecule engages nuclear hormone receptor DAF12/FXR to regulate mitophagy and extend lifespan. Nature Aging 3 (12):
- Liu et al. 2023. Nascent mitochondrial proteins initiate the localized condensation of cytosolic protein aggregates on the mitochondrial surface. Proc Natl Acad Sci USA 120(31) e
- Liu et al. 2022. Tom70 regulates the transcription of nuclearencoded mitochondrial proteins. eLife. 11:e75658
- NietoTorres et al. 2021. LC3B phosphorylation regulates FYCO1 binding and directional transport of autophagosomes. Current Biology 15;S(21)007508
- Domnauer et al. 2021. Proteome plasticity in response to persistent environmental change. Molecular Cell. 81(16):
Required Experience:
Senior IC
Employment Type
Full-Time
