Senior Laboratory Research Scientist Structural Biochemist Visual Biochemistry lab
Senior Laboratory Research Scientist Structural Biochemist Visual Biochemistry lab
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Job Description
Salary for this Role:
From 44360 per annum with benefits subject to skills and experience
Job Title:
Senior Laboratory Research Scientist Structural Biochemist Visual Biochemistry labReports to:
Radoslav EnchevClosing Date:
02/May/2025 23.59 GMTJob Description:
Job title: Senior Laboratory Research Scientist Structural Biochemist Visual Biochemistry lab
Details of the role: 2 yr fixed term fulltime. Working pattern: Monday Friday.
Salary: From 44360 with benefits dependent on skills and experience
Application closing date: 11th April 2025 23:59 GMT
About us
The Francis Crick Institute is Europes largest biomedical research institute under one roof. Our worldclass scientists and staff collaborate on vital research to help prevent diagnose and treat illnesses such as cancer heart disease infectious diseases and neurodegenerative conditions.
The Crick is a place for collaboration innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with stateoftheart infrastructure cuttingedge facilities and a creative and curious culture. Weve removed traditional boundaries of departments divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to collaborate and carry out highquality pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy.
About the role
The Enchev Lab is offering a unique opportunity to get involved in developing and applying methods for directly observing biochemical processes at atomic spatial and millisecond time resolution. Our work combines microfluidics devices to mix and incubate biochemical samples on subsecond timescales with rapid sprayplunge freezing for subsequent threedimensional structure determination by timeresolved cryoEM trEM. By iterating this procedure at increasing incubation times and using machine learningbased approaches to map conformational landscapes we generate timelapse movies of biochemical binding and enzymatic reactions.
This role will support academic and industry collaborations and earlystage proofofconcept trEM studies. Team working and an open mind as to how other disciplines and technologies can advance our work are critical.
Projects may vary in scope and duration. A representative example includes cloning recombinant production and biochemical purification of CullinRING ligases and their substrates followed by biochemical characterization timeresolved cryoEM sample preparation data collection and analysis.
What you will be doing
As an SLRS at the Crick you will be involved in:
Protein Expression and Purification
Design and generate protein expression constructs.
Express recombinant proteins using bacterial and insect cell systems.
Purify recombinant proteins using affinity ion exchange and size exclusion chromatography.
Biochemical and Structural Characterization
Conduct quantitative biochemical binding and activity assays
Carry out standard as well as timeresolved cryoEM sample preparation.
Independently perform singleparticle cryoEM screening and data collection.
Process singleparticle cryoEM datasets.
Perform model building into highresolution cryoEM maps.
About you
The essential criteria you will bring
PhD in biochemistry (or related fields) or equivalent experience
Practical experience with protein expression purification and in vitro protein biochemistry
Theoretical and practical expertise in cryoelectron microscopy single particle analysis and model building
Track record of writing papers as evidenced by preprints and/or publications in peerreviewed journals
Ability to work flexibly both independently and as part of a team
Evidence of data presentation at scientific meetings
To see the complete job description click here.
To see more about the Group Leader click here.
About Working at the Crick
Our values
Everyone who works at the Crick has a valuable role to play in advancing the Cricks mission and shaping our culture!
We arebold. We make space for creative dynamic and imaginative ideas and approaches. Were not afraid to do things differently.
We areopen. Were highly collaborative and interactive and make sure our activities are visible to the outside world.
We arecollegial. We show respect for one another work cooperatively and support the wider community.
At the Francis Crick Institute we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued respected and empowered to succeed regardless of their background identity or personal circumstances. We actively encourage applications from individuals of all genders ethnicities abilities and experiences. We want to ensure that everyone can apply and be part of our team and you will be asked as part of the process if you wish to apply under the Disability Confident scheme. We will make reasonable adjustments if you need them. If you need assistance with applying (i.e. would like to apply by phone or post)please email:
To find out more about life at the Crick click here.
What will you receive
At the Francis Crick Institute we value our team members and are proud to offer an extensive range of benefits to support their wellbeing and development:
Visas: Applicants for this role will be eligible for sponsorship to work in the UK
Generous Leave: 28 days of annual leave plus three additional days over Christmas and bank holidays.
Pension Scheme: Defined contribution pension with employer contributions of up to 16.
Health & Wellbeing:
24/7 GP consultation services.
Occupational health services and mental health support programs.
Eye care vouchers and discounted healthcare plans.
WorkLife Balance:
Backup care for dependents.
Childcare support allowance.
Annual leave purchase options.
Crick Networks offering diverse groups support community and inclusive social events.
Perks:
Discounted gym memberships biketowork scheme and shopping discounts.
Subsidised onsite restaurant and social spaces for team interaction.
Development & Recognition: Comprehensive training mentoring and a pay structure based on skills and experience.
Required Experience:
Senior IC
Employment Type
Full-Time
