Massachusetts General Hospital is an Equal Opportunity Employer. By embracing diverse skills perspectives and ideas we choose to lead. Applications fromprotected veterans and individuals with disabilities are strongly :The Ragon Institute of MGH MIT and Harvard at the Massachusetts General Hospital in Boston has an opening in the Allen laboratory for ahighly motivated postdoctoral fellow to study HIV infection in the newly developed humanized mouse model This NIH funded position requires an M.D. or Ph.D. with a background in infectious diseases and/or immunology. Research will focus on characterizing cellular immunity in humanized BLT mice viral transmission and quasispecies dynamics and test the efficacy of contemporary and novel vaccines to HIV. Efforts will include the analysis of cellular immunity using ELISPOT ICS and proliferation assays the analysis of viral sequence evolution using next generation sequencing technologies such as 454 and conducting vaccine trials in humanized mice. Candidates will implement commercially available and inhouse assays and software tools; interpret results as they relate to the biology of HIV infection; contribute to the design and maintenance of clinical immunology and virology databases; coordinate analyses with collaborators; and communicate results to the scientific community through conference presentations and peerreviewed publications. Goals are to define the successful components of an effective HIV vaccine and advance our understanding of HIV facilities are available within an exceptionally energetic research Title: Postdoctoral Fellow to Study HIV infection in Humanized MiceEmploying Hospital and Department: Ragon Institute of MGH MIT and HarvardMinimum degree and field of knowledge:MD PhD MD/PhD Years experience required: 0 2 years experienceJob Duties:Under the direction of the principal investigator and/or a research fellow the applicant independently carries out daily activities of the of mice is noJob Duties:Under the direction of the principal investigator and/or a research fellow the applicant independently carries out daily activities of the laboratory: Performs assays utilizing standard techniques (antibody staining flow cytometry ELISA DNA/RNA extraction and analysis standard and quantitative PCR sitedirected mutagenesis) Conventional and nextgeneration sequencing Cell/tissue processing culture and maintenance Ensures quality control of equipment reagents and cellular components Detailed documentation of the experimental work Handling of mice is not required Qualifications: A Ph.D. or M.D. with relevant experience in infectious diseases virology immunology or evolutionary biology. Strong candidates will have demonstrated experience in the immunology or virology of infectious diseases. Candidates must be highly motivated and independent with the ability to work in a dynamic team environment. Good organizational skills and excellent attention to detail Excellent documentation skills Ability to perform as a team member Must have good interpersonal skills