Postdoctoral Fellow-MSH
Postdoctoral Fellow-MSH
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Not Disclosed
Salary Not Disclosed
1 Vacancy
Job Description
Title: Postdoc in Shi lab
Salary: $ 7355
Department: Pharmacological Sciences
Physical work location: (must be proper street address):
Name PI or Supervisor: (include phone and email): Yi Shi
Web link to Lab:
Web link to Department: Contact: (phone and email): Yoori Kim
Responsibilities
Details of Research Project:
The incumbent is expected to lead one or more innovative research projects in protein engineering and therapeutics with a primary focus on nanobody development for nextgeneration therapeutic and diagnostic platforms. This role involves designing and optimizing nanobodybased solutions for a range of biomedical applications leveraging cuttingedge AIdriven approaches structural biology and bioengineering techniques.
Projects include: 1 Apply AIdriven design and engineering strategies to develop nanobody candidates targeting infectious diseases cancer diabetes and neurodegenerative disorders. 2 Develop biosensor platforms for highsensitivity detection of blood biomarkers. 3 Engineer and optimize multispecific and multivalent nanobodies for enhanced antiviral and immunotherapy applications. 4 Develop novel strategies to facilitate membrane target degradation and payload delivery of chemical probes and inhibitors.
Collaborative Research & Development: Work closely with crossdisciplinary teams in structural biology computational modeling immunotherapy and chemical biology to advance the development of nextgeneration theradiagnostic technologies. The incumbent will also contribute to manuscript preparation grant proposals and presentations to support research funding and dissemination of findings.
Technical Duties:
The incumbent will be responsible for executing advanced research protocols related to nanobody engineering therapeutic development and biosensor technology. Key technical duties include:
Protein/antibody Engineering:
Protein Expression & Purification:
Expression of recombinant nanobodies and fusion constructs in bacterial mammalian and yeast systems.
Purification using affinity chromatography and sizeexclusion chromatography.
Protein quality assessment through SDSPAGE Western blot and biophysical and binding affinity characterization (DSF DLS MST SPR BLI etc..
Chemical conjugation of nanobodies with payloads (small molecules toxins fluorescent probes).
Cellular & Functional Assays:
Conducting cellbased binding and internalization assays using flow cytometry and confocal microscopy.
Functional testing of multivalent nanobody constructs in immunotherapy applications including cellbased assays and potentially animal models.
Educational and other Requirements for the position: PhD
Goals/Outcomes of the Research Project:
The research project aims to develop and translate nextgeneration nanobodybased therapeutics and diagnostic platforms for applications in infectious diseases cancer neurodegenerative disorders and metabolic diseases. The incumbent will play a key role in advancing protein therapeutics and diagnostic tools contributing to innovations with realworld impact. The successful candidate is expected to publish highquality papers contribute to patent applications and drive forward key discoveries that support both academic and translation. Additionally we are committed to mentoring and supporting the candidates career development providing opportunities to transition into leading roles in academia biotechnology or pharmaceutical industries.
Qualifications
Experience Required:
A Ph.D. in biochemistry bioengineering immunology chemical biology structure biology or a related field.
Strong expertise in protein/antibody engineering or chemical biology.
Handson experience in biochemistry and biophysics.
Experience in cellbased assays livecell imaging and immunoassays.
Familiarity with chemical conjugation techniques for targeted payload delivery is desirable.
Computational skills in protein modeling docking or protein design are a plus.
A strong track record of peerreviewed publications in relevant fields.
Ability to work independently and collaboratively in a dynamic research environment.
858 Pharmacological Sciences ISM Icahn School of Medicine
Employment Type
Full-Time
