Bioinformatics Analyst Cheminformatics
Bioinformatics Analyst Cheminformatics
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Job Description
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The University of Miami/UHealth Department of SCCC has an exciting opportunity for a Full Time Bioinformatics Analyst (Cheminformatics) to work the UHealth Medical Campus in Miami FL 33146.
CORE JOB SUMMARY
The Bioinformatics Analyst works with research staff to extend capabilities in bioinformatics and improve understanding of genetic variation in human health and disease. The Bioinformatics Analyst maintains and
performs analysis with existing pipelines while assisting and benchmarking the development of novel methods.
CORE JOB FUNCTIONS
Runs and maintains existing next generation data analysis pipelines.
Assists senior bioinformatics analysts in pipeline and algorithm development and validation.
Extracts features of interest from data relating to specific biological questions.
Contributes to the maintenance of genomic and clinical databases.
Performs statistical and integrative data analysis on genomics and clinical data.
Works alongside other team members and data analysts.
Follows standard operating procedures documentation and scripts to generate reports.
Adheres to University and unitlevel policies and procedures and safeguards University assets.
This list of duties and responsibilities is not intended to be allinclusive and may be expanded to include
other duties or responsibilities as necessary.
CORE QUALIFICATIONS
Education:
PhD degree in relevant field
Experience:
Minimum 1 year of relevant experience
Knowledge Skills and Attitudes:
Skill in collecting organizing and analyzing data.
Ability to recognize analyze and solve a variety of problems.
Ability to exercise sound judgment in making critical decisions.
Ability to process and handle confidential information with discretion.
Proficiency in computer software.
Department Specific Functions & Qualifications
The Sylvester Comprehensive Cancer Center & the Department of Molecular and Cellular Pharmacology are actively
seeking a fulltime Bioinformatics / Cheminformatics Analyst to work on the UHealth campus in Downtown Miami. At
Sylvester we are at the cutting edge of healthcare innovation leveraging artificial intelligence and machine learning to
transform drug discovery and development. Our mission is to accelerate the delivery of therapeutic solutions to patients
through stateoftheart technology and groundbreaking research. The Analyst will leverage expertise in computational
chemistry bioinformatics and AI to process and analyze largescale biomedical small molecule bioactivity structural
biology image and clinicogenomic datasets integrating them with the Sylvester Data Portal. The successful candidate
will work within an interdisciplinary team of research scientists data engineers and fullstack developers using
stateoftheart software development practices to enhance the universitys research activities.
Primary Responsibilities:
Process and analyze largescale multiomics and drug discovery datasets (WES WGS bulk/singlecell
RNASeq ATACSeq Drug Screening CRISPR Screening).
Develop and maintain productiongrade pipelines for processing and analysis of diverse biomedical datasets.
Develop visualization and bioinformatic analysis tools for exploring diverse biomedical data.
Integrate developed tools and pipelines with Sylvesters internal enduser data analytics platform.
Apply stateoftheart AI bioinformatics and biostatistics approaches to cancer precision medicine.
Write standard operating procedures and other relevant documentation.
Develop and apply AI/ML models for structurebased and ligandbased drug design.
Utilize computational tools to predict and optimize pharmacokinetic (PK) and pharmacodynamic (PD) properties
of drug candidates.
Design and implement algorithms to identify novel drug candidates and elucidate their mechanisms of action.
Integrate and analyze largescale biological chemical and clinical datasets to extract insights and inform drug
discovery decisions.
Collaborate with crossfunctional teams to advance drug discovery projects.
Analyze and interpret PK/PD data using advanced statistical and modeling software.
Stay updated with advancements in computational chemistry AI and bioinformatics.
Contribute to the development of new computational tools and methodologies.
Present findings to both technical and nontechnical stakeholders.
Participate in scientific discussions and strategy meetings providing AI/ML expertise.
Author scientific papers reports and patents related to AI/ML in drug discovery.
Preferred Requirements
PhD or MSc degree in computational chemistry computational biology medicinal chemistry pharmaceutical
sciences computational sciences or a related field.
Fluency in R or Python and Unix (bash).
Experience with analyzing and interpreting different omics and/or drug discovery datasets (WES WGS
bulk/singlecell RNASeq ATACSeq Drug Screening CRISPR Screening).
Experience with using common opensource bioinformatics/NGS workflows (BWA STAR Picard GATK etc..
Familiarity with machine learning frameworks (e.g. Scikitlearn TensorFlow PyTorch) and developing and
deploying machine learning models.
Highly motivated strong work ethic and able to work independently and with a team.
Excellent skills in communication organization and time management.
Preferred Qualifications
For Ph.D. holders: 03 years of relevant experience in computational chemistry AI and drug discovery.
Deep expertise with chemical toolkits such as DeepChem ChemAxon OEChem or RDKit.
Familiarity with drug discovery databases (CTRP GDSC PRISM CCLE DepMap LINCS) and publicly available
clinicogenomic datasets (CPTAC TCGA AACR Project GENIE etc..
Experience with Cloud Computing Environments (e.g. Azure).
Familiarity with relational (e.g. PostgreSQL) and/or NoSQL databases (e.g. MongoDB).
Familiarity with container technologies (e.g. Docker).
Experience with Generative AI tools and techniques.
Familiarity with High Performance Computing.
Familiarity with version control (Git).
#LIYC1
The University of Miami offers competitive salaries and a comprehensive benefits package including medical dental tuition remission and more.
UHealthUniversity of Miami Health System South Floridas only universitybased health system provides leadingedge patient care powered by the ground breaking research and medical education at the Miller School of Medicine. As an academic medical center we are proud to serve South Florida Latin America and the Caribbean. Our physicians represent more than 100 specialties and subspecialties and have more than one million patient encounters each year. Our tradition of excellence has earned worldwide recognition for outstanding teaching research and patient care. Were the challenge youve been looking for.
The University of Miami is an Equal Opportunity Employer Females/Minorities/Protected Veterans/Individuals with Disabilities are encouraged to apply. Applicants and employees are protected from discrimination based on certain categories protected by Federal law. Click here for additional information.
Job Status:
Full timeEmployee Type:
StaffPay Grade:
A9Required Experience:
IC
Employment Type
Full-Time
